Evening session (Paul Ornstein, Eli Lilly & Co., discussion leader)

7:20 - 7:30 pm Greeting by Gordon Conference Chair and Staff

7:30 - 8:15 Alex Bridges, Warner Lambert Co., Parke Davis Research Division - A Plethora of Polycyclic Pyrimidines Produced to Pacify a Problematic Proliferative Protein. A Square SAR for a Round Binding Site

8:15 - 8:30 Discussion

8:30 - 9:25 Albert Padwa, Emory University - The Rhodium Route to Heterocycles

9:25 - 9:40 Discussion

Morning session (Mark C. Noe, Pfizer, Inc., discussion leader)

8:30 - 9:20 Steven Weinreb, Pennsylvania State University - New Methodology for Alkaloid Total Synthesis

9:20 - 9:35 Discussion

9:35 - 10:20 William V. Murray, R. W. Johnson Pharmaceutical. Res. Inst. - Diketopiperazines in Chiral Synthesis

10:20 - 10:35 Discussion

10:35 - 11:20 Break and photograph

11:20 - 12:05 Brian P. Coppola, University of Michigan - Studies on the Regioselectivity of 1,3-Dipolar Cycloadditions of Mesoionic Compounds with Acetylenic Dipolarophiles

12:05 - 12:20 Discussion

4:00 - 6:00 Poster Session #1

Evening session (Cynthia K. McClure, Montana State Univ., discussion leader)

7:30 - 8:00 Jon Jacobsen, Pharmacia and Upjohn - Piperazine Imidazo[1,5-a]quinolines and Imidazo[1,5-a]quinoxalines as High-Affinity GABAA Ligands of Dual Functionality

8:00 - 8:10 Discussion

8:10 - 8:30 Gretchen Rehberg, Bucknell University - The synthesis of Cystodytin A

8:30 - 8:40 Discussion

8:40 - 9:35 Edwin Vedejs, University of Wisconsin - Nitrogen Alpha Activation en route to Aziridinomitosenes

9:35 Discussion

Morning session (Stephen Godleski, Eastman Kodak, discussion leader)

8:30 - 9:20 James Rigby, Wayne State University - Recent Applications of Vinyl Isocyanates for Alkaloid Synthesis

9:20 - 9:35 Discussion

9:35 - 10:15 Susan Daluge, Glaxo-Wellcome - Synthesis and Clinical Evaluation of the Nucleoside HIV-RT Inhibitor 1592U89

10:15 - 10:30 Discussion

10:30 - 11:15 Break, Meeting of GRC Heterocycles Chairs, Past, Present, & Future

11:15 - 12:05 Janine Cossy, ESPCI, France - Cyclization Reactions - Synthesis of Biologically Active Natural and Non-Natural Products

12:05 - 12:20 Discussion

Evening session (Martin Osterhout, Bayer Corp., discussion leader)

7:30 - 8:00 Allen J. Duplantier, Pfizer - The Chemistry of Tetrahydropyrazolopyridinones as Novel Inhibitors of Human Eosinophil Phosphodiesterase

8:00 - 8:10 Discussion

8:10 - 8:30 Joseph Konopelski, Univ. of California at Santa Cruz - Asparagine-Derived Tetrahydropyrimidinones: Access to Unusual Amino ACids and Dipeptide Building Blocks

8:30 - 8:40 Discussion

8:40 - 9:35 Dennis Curran, University of Pittsburgh - Fluorous Strategies for Traditional and Combinatorial Synthesis of Isoxazolines, Tetrazoles and Other Heterocycles

9:35 Discussion

Morning session (George Sheppard, Abbott Laboratories, discussion leader)

8:30 - 9:20 Miwako Mori, Hokkaido University - Synthesis of Heterocycles Using Transition Metal Complexes

9:20 - 9:35 Discussion

9:35 - 10:15 J. Michael Williams, Merck & Co. - A Practical Synthesis of the New Broad-Spectrum Carbapenem Antibiotic L-749,345

10:15 - 10:30 Discussion

10:30 - 10:50 Short Break

10:50 - 11:00 Nominations for 1999 Chair

11:00 - 11:20 John Montgomery, Wayne State University - Nickel-Catalyzed Cyclizations and Multicomponent Couplings

11:20 - 11:30 Discussion

11:30 - 12:15 Frank McDonald, Northwestern University - Metal-Promoted Oxacyclization Reactions

12:15 - 12:30 Discussion

4:00 - 6:00 Poster Session #2

Evening session (Stephen Bergmeier, Ohio State Univ., discussion leader)

7:30 - 8:00 Guangzhong Wu, Schering Plough - Catalytic Enantioselective Synthesis of Spiro-Fused Beta-Lactam

8:00 - 8:10 Discussion

8:10 - 8:30 David Myles, UCLA - The Total Synthesis of (-)-Discodermolide

8:30 - 8:40 Discussion

8:40 - 9:35 Andrew Holmes, University of Cambridge - Pericyclic Processes in the Synthesis of Heterocyclic Natural Products

9:35 Discussion

Morning session (Raymond C. F. Jones, The Open University, discussion leader)

8:30 - 9:20 David Hart, Ohio State University - Studies in Alkaloid Synthesis

9:20 - 9:35 Discussion

9:35 - 10:15 Mark Tebbe, Eli Lilly & Co. - The Antirhinoviral Benzimidazoles: Towards a Cure for the Common Cold

10:15 - 10:30 Discussion

10:30 - 10:40 Election of 1999 Chair

10:40 - 11:10 Break

11:10 - 12:00 Sunggak Kim, KAIST, Korea - Chemistry of N-Aziridinyl Imines

12:00 - 12:15 Discussion

Evening session (Nancy Totah, Univ. of Iowa, discussion leader)

7:30 - 8:25 Paul Wender, Stanford University - Simplifying Nature: Synthetic, Spectroscopic, Computer, and Biological Studies on the Chemistry-Medicine Continuum

8:25 - 8:45 Discussion

8:45 - ??? Paul Ornstein: Remarks