Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Paradigm-Shifting Heterocycle Synthesis and Functionalization
Discussion Leader: Dani Schultz (Merck, United States)
7:40 pm - 8:15 pm
Jonathan Ellman (Yale University, United States)
"Non-Aromatic Nitrogen Heterocycles: Synthesis, Stereochemical Editing, and Biomedical Applications"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Jessica Lamb (University of Minnesota, United States)
"Switchable Organocatalysis from Modular N-Heterocyclic Carbene-Carbodiimide Adducts"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Huw Davies (Emory University, United States)
"Collaborative Approaches to Make Rhodium Carbenes Behave Nicely with Heterocycles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Biologically Active Heterocycles
Discussion Leader: Joe Topczewski (Corteva, United States)
9:00 am - 9:30 am
Kelly Chibale (University of Cape Town, South Africa)
"Spirocyclic Heterocycles as Scaffolds for the Medicinal Chemistry of Novel Antimalarial Agents"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Nicole Goodwin (GSK, United States)
"GSK + UW + H2O = Formula for Sustainable Oxygen-Atom-Transfer Reactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Daniel Klosowski (Corteva Agriscience, United States)
"Development of a Sustainable Process for Metarylpicoxamid from Renewable Raw Materials"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Sarah Steinhardt (Bristol Myers Squibb, United States)
"Development of a Four Step Route to Branebrutinib"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Dani Schultz (Merck, United States) and Catharine Larsen (University of California, Riverside, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computer-Assisted Synthesis Applied to Heterocycles
Discussion Leader: Nicholas Chiappini (University of North Carolina - Wilmington, United States)
7:30 pm - 8:00 pm
Timothy Cernak (University of Michigan, United States)
"Combinatorial Explosion: From Atom-Bond Arrangements to Exotic Diseases"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Martin Burke (University of Illinois at Urbana-Champaign, United States)
"Imagine a World Where Everyone Can Make Molecules"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Dipannita Kalyani (Merck & Co., Inc., United States)
"Catalyzing Molecular Invention Leveraging Industry-Academia Collaborations"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Methods for the Synthesis of Heterocyclic Compounds
Discussion Leader: Brian Aquila (Alkermes, Inc., United States)
9:00 am - 9:30 am
Janine Cossy (ESPCI Paris, France)
"Transition Metals: Useful Tools to Synthesize Heterocycles"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Jennifer Schomaker (University of Wisconsin-Madison, United States)
"Merging Nitrene and Carbene Reactivity: Flexible Access to High Fsp3 Chemical Space"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Chi Ting (Brandeis University, United States)
"Chemical and Biocatalytic Syntheses of Amino Acid-Derived Natural Products"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
Dan Griffith (Lafayette College, United States)
"Tropone as a Platform for the Synthesis of Diverse Azapolycycles"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Janine Tom (Amgen, United States)
"Development of a GalNAc Targeting Ligand for Oligonucleotide Therapeutics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biocatalysis for Heterocycle Synthesis and Functionalization
Discussion Leader: Courtney Roberts (University of Minnesota, United States)
7:30 pm - 8:00 pm
Jeffrey Kohrt (Pfizer Global R&D, United States)
"Application of Biocatalysis Technology to the Unique Challenges of Early Medicinal Chemistry Programs"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Alison Narayan (University of Michigan, United States)
"Biocatalysis and Complex Molecule Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Yang Yang (University of California Santa Barbara, United States)
"Stereoselective Radical Biocatalysis for Heterocycle Synthesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterocycles and Catalysis
Discussion Leader: Amanda Jones (Wake Forest University, United States)
9:00 am - 9:30 am
Kami Hull (University of Texas at Austin, United States)
"Transition-Metal Catalyzed Aminofunctionalizations"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Shashank Shekhar (AbbVie, United States)
"Strategies for the Synthesis of Drug Substance (ABT-530) on Multi Kilogram Scale."
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Vy Dong (University of California, Irvine, United States)
"A Few of My Favorite Rings"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Debabrata Maiti (IIT Bombay, India)
"Unlocking New Chemical Space via Selective Catalysis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Strategies to Construct Heterocycles
Discussion Leader: Aaron Sather (Merck & Co., Inc., United States)
7:30 pm - 8:00 pm
Ed Anderson (University of Oxford, United Kingdom)
"Thiophene S,S-Dioxides: Opportunities for the Concise Synthesis of Bioactive Scaffolds"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Erik Alexanian (UNC Chapel Hill, United States)
"Radical-Mediated C(sp3 ): H Functionalizations for Heterocycle Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Marisa Kozlowski (University of Pennsylvania, United States)
"Isotopic Labelling for Direct Identification of Isomers"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Heterocycles in Medicine, Technology, and Catalysis
Discussion Leader: Colleen Scott (Mississippi State University, United States)
9:00 am - 9:30 am
Song Lin (Cornell University, United States)
"New Methods and Technologies for Organic Electrosynthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Sherry Chemler (State University of New York at Buffalo, United States)
"Enantioselective Synthesis of Saturated Hetereocycles and their Applications to the Synthesis of Bioactive Compounds"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Ana Bahamonde (University of California Riverside, United States)
"Advancing Llight-Mediated Ni Catalysis Using Data Science and Physical Organic Techniques"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
Antonio Navarro (Eli Lilly, United States)
"Development of a New Synthetic Route Towards Exo-3-Azabicyclo[3.1.0]hexane-6-carboxylate as Intermediate in the Synthesis of 3-azabicyclo[3.1.0]hexane-6-carboxamide derivative "
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Carina Sanchez (Novartis, United States)
"Advancements in the Synthesis of Molecular Glues"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Transformational Heterocyclic Compounds
Discussion Leader: Sidney Wilkerson-Hill (The University of North Carolina at Chapel Hill, United States)
7:30 pm - 8:10 pm
Francis Gosselin (Genentech, Inc., United States)
"Efficient Process Chemistry Enabled by Asymmetric Catalysis and Data Science"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:05 pm
Erick Carreira (ETH Zurich, Switzerland)
"Advances in Synthesis of Complex Molecules Bearing Heterocycles"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure