Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Heterocycles Inspiring Creativity in Organic Synthesis
7:40 pm - 8:15 pm
"Synthesis Through C–C Bond Scission"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Simple-Looking but Non-Obvious Transformations"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring Heterocycles as Bioactive Molecules
9:00 am - 9:30 am
"Advances in Agrochemical Discovery at FMC"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Redox-Economic Alkaloid Synthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Discovery of Rinvoq® (Upadacitinib): A Potent and Selective Jak1 Inhibitor"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Orforglipron: Development of a Convergent Synthesis of a Complex Heterocycle"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Heterocycles as Inspiration for Synthesis
7:30 pm - 8:00 pm
"Evolution of a Concise Approach to Chiral Cyclohexyl Based Drug Candidate BMS-986278 (Admilparant)"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Triazole-Based Enantioselective Anion-Binding Catalysis: From the Design to Synthetic Applications"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Mechanism-Driven Predictive Model for the Catalyst-Controlled Asymmetric Rh(I)-Catalyzed Pauson–Khand Reaction"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methodology and Heterocycle Synthesis
9:00 am - 9:30 am
"New Methods Using A-Carbonyl Sulfoxonium Ylides to Achieve Heterocycles"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Boron Trihalides as Versatile Reagents in Synthetic Strategy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Engaging Undergraduates in Organic Chemistry to Diversify the Field"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"A General Platform for the Synthesis of Organofluorine Compounds"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Complex Heterocycle Discovery and Assembly
7:30 pm - 8:00 pm
"Unexpected Heterocyclic Alkaloids from Millipede Secretions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Building Bonds with Boron"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Heterocycles: Where Would I Be Without Them!"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Heterocyclic Compounds
9:00 am - 9:30 am
"Development of Efficient Routes to 6-Aryl Picolinate Herbicides"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Small Ring Heterocycles as Mediators for Catalytic Asymmetric Dearomatization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"The Evolution of Synthesis: From Research to Developmen"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Sustainable Strategies for Synthesizing Heterocyclic Drug Substances at Boehringer"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis and Heterocyclic Compound Synthesis
7:30 pm - 8:00 pm
"Development of a Continuous Process to the Pyridine Core of SAR443820"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"High-Throughput Experimentation: A Catalyst for Innovation Across Drug Modalities and Development Stages"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Functionalized Heterocycles Derived from Carbon Dioxide Enabled by Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Heterocycle Synthesis and Design
9:00 am - 9:30 am
"Heterocyclics in Dyes and Conducting Polymeric Materials"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mining Peptide Macrocycles in the Plant Kingdom"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Switching the Immune System Off and On Through Computationally Enabled Drug Discovery: Discovery of TYK2 Inhibitor Zasocitinib for Immune Disorders and HPK1 Inhibitor NDI-101150 for Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Building Efficient, Diastereo- and Enantioselective Synthetic Routes to Trans-Cyclopropyl Esters for Rapid Lead Scale-Up"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Transformative Power of Heterocycles
7:30 pm - 8:15 pm
"Attempts to Deliver on the Promise of Natural Products"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"New Aspects of Chiral Brønsted Acid and Base Catalysis"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure