Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Scaling Chemical and Biological Data for AI-Driven Drug Discovery
7:40 pm - 8:25 pm
"DEL Data and ML Binding Models: Factors Impacting Predictive Accuracy"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Chemical Approaches to Regenerative Organ Repair"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Allosteric Drug Discovery in the Age of Machine Learning"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Mechanisms of Induced Proximity
9:00 am - 9:25 am
"Interrogating the Druggable Proteome with Proximity Pharmacology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"New Approaches to Target Undruggable Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"MrTAC: Harnessing the Lysosome for Targeted Degradation of the Intracellular Proteome"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Fluorine-Displacement Probes to Interrogate Post-Translational Modification Related Protein-Protein Interactions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Expanding what is Druggable Today
7:30 pm - 7:50 pm
"Exploring PRMT Selectivity: Mapping Active Site Landscapes for Selective Drug Discovery"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Structure-Based Design of Small Molecule Inhibitors of Protein Arginine Methyltransferase 5 (PRMT5)"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"SPEAR-GN: A Data-Driven Machine Learning Approach to Enable Rational Design of Gram-Negative Permeant Molecules"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Decoding Transcription Coactivators: Mechanisms & Molecules"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Encoding and Predicting Therapeutic Function of Oligonucleotides
9:00 am - 9:25 am
"Engineering Polymerases for Applications in Synthetic Biology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Characterization and Inhibition of lncRNA-Protein Interactions by Chemical Probing Assays and NMR Spectroscopy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Delivering the Promise of RNAi to Extra-Hepatic Tissues"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Chemically Formulating Functional Nucleic Acids to Overcome Biological Barriers to Enhance Their Cytosolic Delivery and Therapeutic Effects"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Encoded Synthesis in Drug Discovery
7:30 pm - 7:50 pm
"Beyond Binding: Phenotypic and Functional Screening of Encoded Libraries"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Using Surfactant-DNA Complexes to Access New DEL Chemical Space"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Using DEL for Targeted Protein Degradation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Phenotypic DEL in Droplets for TPD and Beyond"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enhancing the Chemistry-Biology Interface: Automation and OMICs Analytics
9:00 am - 9:20 am
"Understanding and Predicting the Membrane Permeability of Cyclic Peptides Based on Large-Scale Data"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Chemical Synthesis and Direct-to-Biology Cellular Evaluation for the Discovery of a Lead GPCR Agonist"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Leveraging Automation in a High-Throughput Experimentation Platform to Fuel ML-Driven Drug Discovery"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Matrix Completion of Palladium, Nickel, and Copper Catalyzed C–N Cross Couplings"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Development and Implementation of ML Tools to Impact Medicinal Chemistry Campaigns"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Automated Synthesis Platform at J&J: Innovative Workflows and Case Studies in HTE, PMC and D2B"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Generating Insights: AI / ML at the Chemistry-Biology Interface
7:30 pm - 7:50 pm
"Leveraging ML for Drug Discovery and Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Strategy and Use-Cases of Establishing a Predictive Synthesis Analytics/AI Integration Within Industry Portfolio Projects"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"NeuralPLexer3: Accurate Biomolecular Complex Structure Prediction with Flow Models"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Accelerating the Synthesis of Small Molecule Drugs Through Automation and AI-Driven Chemistry"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
High Throughput Phenotypic Screening and Deconvolution
9:00 am - 9:25 am
"In Vivo Neuroactive Small Molecule Discovery Using Larval Zebrafish"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Quantitative High-Throughput Screening of Human Neurodevelopment Using RosetteArray® Technology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Expanding Molecular Diversity with pDOS Strategy to Modulate Protein-Protein Interactions"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Finding Disease Phenotypes and Candidate Therapeutics Using Images: Cell Painting"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Perspectives and Applications of Generative AI
7:30 pm - 7:45 pm
Short Talk Selected from Poster Abstracts
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"Leveraging AI and Generative Modeling to Accelerate Hit Finding in Early Drug Discovery"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Generative AI in Drug Discovery: Revolution, Evolution, or Complete Nonsense"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure