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Histone and DNA Modifications

Gordon Research Conference

Regulation of Genome Function by Histone and Nucleic Acid Modifications in Health, Development and Disease

July 20 - 25, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by June 22, 2025. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Histone and DNA Modifications GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Histone, DNA, and RNA modifications are central players in the regulation of genome function. Modifications such as methylation, acylations, phosphorylation, and other modification types play major roles in the transmission of epigenetic information. They dictate chromatin structure and function and are relevant to physiology and pathology. Recent seminal discoveries have greatly expanded our understanding of the importance of histone, DNA, and RNA modifications; however, many essential questions remain unanswered. At our 2025 GRC, we will discuss key concepts and mechanisms focusing on diverse systems, approaches, and experimental innovations. This meeting will bring together scientists from multiple disciplines, including molecular biology, biochemistry, epigenetics, chemical and structural biology, and chemistry, addressing both basic and translational concepts and presenting new advances. We look forward to an exciting exchange of viewpoints, stimulating discussions of novel ideas and discoveries, and forging new collaborations.

Related Meeting

This GRC will be held in conjunction with the "Histone and DNA Modifications" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Discoveries of Chromatin Modifications Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:20 pm	"Roles of Histone Methylation in Transcription and Development"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:05 pm	"Distinct Phases of Polycomb Silencing to Hold Epigenetic Memory of Cold"
9:05 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Histone Lysine Methylation: Biology and Molecular Mechanisms Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Enhancer Regulation by H3K4me1 Methyltransferases"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Epigenetics: A Gatekeeper to DNA Amplification and Rearrangements"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Molecular Mechanisms of Epigenetic Regulation"
11:15 am - 11:25 am	Discussion
11:25 am - 11:35 am	Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am	Discussion
11:55 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Biological Role of Histone Lysine Acylation Discussion Leader:
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:25 pm	"Acetylation and Incorporation of H2AZ in Gene Regulation and Disease"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:55 pm	"The Histone Acetylation Reader ENL in Development and Cancer"
6:55 pm - 7:05 pm	Discussion
7:05 pm - 7:20 pm	Short Talk Selected from Poster Abstracts
7:20 pm - 7:25 pm	Discussion
7:25 pm - 7:35 pm	Short Talk Selected from Poster Abstracts
7:35 pm - 7:40 pm	Discussion
7:40 pm - 7:50 pm	Short Talk Selected from Poster Abstracts
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Crosstalk of Histone Post Translational Modifications Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"SETD2 on Double Duty: A Multitasking Histone Methyltransferase for Chromatin and Nuclear Lamina"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Revealing Molecular Determinants of Chromatin Access and Regulation"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Chemical Approaches to Studying Chromatin"
11:15 am - 11:25 am	Discussion
11:25 am - 11:35 am	Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am	Discussion
11:55 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	RNA Modifications: Mechanisms and Function Discussion Leader:
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:25 pm	"Maintenance and Erasure of Epigenetic Information Across the Germline Cycle"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:55 pm	"Epigenetics of Sex Differences"
6:55 pm - 7:05 pm	Discussion
7:05 pm - 7:20 pm	Short Talk Selected from Poster Abstracts
7:20 pm - 7:25 pm	Discussion
7:25 pm - 7:35 pm	Short Talk Selected from Poster Abstracts
7:35 pm - 7:40 pm	Discussion
7:40 pm - 7:50 pm	Short Talk Selected from Poster Abstracts
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	DNA Modifications: Mechanisms and Function Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Mechanism of DNA Methylation in a Chromatin Context"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"DNA (Hypo)Methylation and Genome (In)Stability"
9:55 am - 10:05 am	Discussion
10:05 am - 10:35 am	Coffee Break
10:35 am - 10:45 am	Short Talk Selected from Poster Abstracts
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	Short Talk Selected from Poster Abstracts
11:00 am - 11:05 am	Discussion
11:05 am - 11:25 am	"Single Cell Multiomics Landscape of Development and Ageing"
11:25 am - 11:35 am	Discussion
11:35 am - 12:20 pm	Late-Breaking Topic
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Chromatin Modifications and Epigenetics Discussion Leader:
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:25 pm	"The Establishment of Nuclear Organization in Mouse Embryos is Orchestrated by Multiple Chromatin Modifier Pathways"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:55 pm	"Understanding How CpG Islands Regulate Transcription"
6:55 pm - 7:05 pm	Discussion
7:05 pm - 7:15 pm	Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:40 pm	"Non-Catalytic Activity of Histone Methyltransferases and Their Role in Epigenetic Inheritance"
7:40 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Histone, DNA, and RNA Modifications in Human Disease Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"H3K36 Methylation in the Regulation of Chromatin and Cancer Biology"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"PRMT5 and its Effector SND1 Regulate S6K2 Kinase Activity"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:10 am	Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Epigenetic Regulation of Drug Resistance in Cancer"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Epigenetic Therapeutics Discussion Leader:
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:25 pm	"Development of Chemical Probes from PHD Family of Chromatin Reader Domains"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:55 pm	"Targeting Histone Lysine Acetylation in Cancer"
6:55 pm - 7:05 pm	Discussion
7:05 pm - 7:15 pm	Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:30 pm	Short Talk Selected from Poster Abstracts
7:30 pm - 7:35 pm	Discussion
7:35 pm - 7:45 pm	Short Talk Selected from Poster Abstracts
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

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Conference History Histone and DNA Modifications (GRS) Contribute Financially to This Conference

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

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Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,610.00

Conferee Shared Room:

$1,325.00

Conferee Off-Site:

$915.00

Guest Single Room:

$1,420.00

Guest Shared Room:

$1,135.00

Guest Off-Site:

$725.00

Child 4-12 yrs Shared Room:

$568.00

Child 4-12 yrs Off-Site:

$363.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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May 31 - June 5, 2026

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August 10 - 15, 2025

Histone and DNA Modifications (GRS)

July 19 - 20, 2025

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