Afternoon |
4:00-6:00 p.m. | Registration and Reception |
Evening |
6:00-7:15 p.m. | Dinner |
7:15-7:30 p.m. | Welcome - Shuk-mei Ho, Chair-Elect, Tufts University |
7:30-8:20 p.m. | Keynote Address: Jan-Ake Gustafsson, Karolinska Institute
"Estrogen receptor-ß: structure and function." |
Session I - Promise and Reality of Chemoprevention |
8:20-8:30 p.m. | Discussion Leader: Michael A. Gallo, Conference Vice-Chair,
New Jersey, Robert Wood Johnson Medical School |
8:30-9:15 p.m. | Craig Jordan, Northwestern University Medical School
"The estrogen receptor as a target for the prevention of breast cancer." |
9:15-10:00 p.m. | Douglas Muchmore, Eli Lilly and Company
"Raloxifene and breast cancer chemoprevention." |
Morning |
7:15-8:00 a.m. | Breakfast |
Session II - Molecular Basis of Cancer Risks and Susceptibility |
8:40-8:55 a.m. | Discussion Leader: Jose Russo, Fox Chase Cancer Center |
8:55- 9:35 a.m. | Louise Brinton, Environmental Epidemiology Branch, National Cancer Institute "Risk factors for breast and gynecological cancers." |
9:35-10:15 a.m. | Ed Giovannucci, Harvard Medical School
"Risk factors for prostate cancer." |
10:15-10:45 a.m. | Ronald K. Ross, University of Southern California
"Building polygenic models of hormonal carcinogenesis." |
10:45-11:00 a.m. | Coffee break |
11:00-11:40 p.m. | Wayne D. Tilley, Flinders University of South Australia
"Androgen receptor: structure and function." |
11:40-12:20 p.m. | Samuel C. Mok, Brigham and Women's Hospital, Harvard Medical School "Genetic determnants of ovarian cancer." |
12:20-12:35 p.m. | David Sassoon, Mt. Sinai Medical School "Identification of target genes in female reproductive tract cancers - A model for endocrine disruption." |
12:45- 1:15 p.m. | Lunch |
Afternoon |
4:00 - 6:00 pm | Poster session I |
Evening |
6:00-7:15 p.m. | Dinner |
Session III - Hormone Induced Genetic and Epigenetic Alterations |
7:15-7:30 p.m. | Discussion Leader: John A. McLachlan, Center for Bioenvironmental
Research, Tulane and Xavier Universities |
7:30-8:15 p.m. | Carl J. Barrett, National Institute of Environmental Health Sciences
"Genetic mechanisms of estrogens." |
8:15-9:00 p.m. | Peter A. Jones, University of Southern California
"Epigenetic alterations: Methylation and histone deacetylation." |
9:00-9:45 p.m. | Shuk-mei Ho, Tufts University
"Estrogen and antiestrogen actions on postatic epithelial cells." |
9:45-10:00 p.m. | Seshadri Tekur, University of Massachusetts Medical School
"Involvement of ARA70 in prostate carcinogenesis" |
Morning |
7:15-8:00 a.m. | Breakfast |
Session IV - Molecular Mediators of Steroid Hormone Actions |
8:00-8:10 a.m. | Discussion Leader: Geoffrey L. Greene, University of Chicago |
8:10-8:50 a.m. | Geoffrey L. Greene, University of Chicago
"Lessons learned from the structure of human estrogen receptors." |
8:50-9:30 a.m. | Peter J. Kushner, University of California at San Francisco
"The origins of the estrogen-like effects of tamoxifen." |
9:30-10:10 a.m. | Jennifer Richer, University of Colorado Health Sciences Center
"Convergence of progesterone with growth factor and cytokine signaling in breast cancer: Progesterone receptors regulate STAT expression and activity." |
10:10-10:50 a.m. | Suzanne Fuqua, University of Texas Health Center
"A somatic mutation in estrogen receptor-alpha in premalignant breast disease." |
10:50-11:05 a.m. | Coffee break |
11:05-11:45 p.m. | Gopalan Shyamala, University of California at Berkeley
"Role of progesterone receptor and its isoforms in mammary development and its implications to carcinogenesis." |
11:45-12:20 p.m. | Chawnshang Chang, University of Rochester
""Cross-talk of estrogen receptor with other member of teh steroid receptor super-family |
12:30-1:15 p.m. | Lunch |
Afternoon |
4:00 - 6:00 p.m. | Informal discussion on career development and grantsmanship. |
Evening |
6:00-7:15 p.m. | Dinner |
Session V - Environmental Impacts on Carcinogenesis and Cancer Susceptibility |
7:15-7:30 p.m. | Discussion Leader: Shuk-Mei Ho |
7:30-8:15 p.m. | Gail S. Prins, University of Illinois at Chicago
"Early imprinting of the rat prostate gland." |
8:15-9:00 p.m. | Shiuan Chen, City of Hope National Medical Center
"Environmental agents and aromatase activity." |
9:00-9:45 p.m. | Williams F. Greenlee, University of Massachusetts Medical School
"Regulation and function of CYP1B1 in human mammary and prostate epithelial cells." |
9:45-10:00 p.m. | Mathew E. Burow, Tulane/Xavier Center for Bioenvironmental Research
"Antiestrogenic activity of flavanoid phytochemicals mediated via c-Jun N-terminal protein kinase and p38 mitogen activated kinase pathways." |
Morning |
7:00-8:10 a.m. | Breakfast |
Session VI - Hormonal Regulation of Cell Cycle Checkpoints and Death Signaling |
8:10-8:25 a.m. | Discussion Leader: Irwin Leav, Tufts University School of medicine |
8:25-9:10 a.m. | Natasha Kyprianou, University of Maryland School of Medicine
"Restoration of TGF-ß signaling pathway in human prostate cancer cells suppresses tumorigenicity via deregulation of cell cycle progression and induction of caspase 1-mediated apoptosis." |
9:10-9:55 a.m. | Ewen, M.E., Dana-Farber Cancer Institute, Harvard Medical School
"Estrogen receptor, cyclin D1, and cell cycle regulators." |
9:55-10:40 a.m. | Marianne Sadar, British Columbia Cancer Agency
"The role of ligand-independent activation of the androgen receptor in the hormonal progression of prostate cancer." |
10:40-10:55 a.m. | Coffee break |
10:55-11:40 a.m. | Massimo Loda, Harvard Medical School
"Androgen regulation of p27 in normal and neoplastic prostate." |
11:40-12:25 p.m. | James Norris, Medical University of South Carolina
"Apoptotic signaling (fission reaction) induced death of breast and prostate cancer cells by administration of adenoviral vector expressing modified FasL." |
12:25-12:40 p.m. | Gerhard Coetzee, Norris Cancer Center, University of Southern California
"Coactivation of the androgen receptor through its TAD; inhibition by polymorphic poly-Q." |
12:40 -12:55 p.m. | Sohaib A. Khan, University of Cincinnatti College of Medicine
"Understanding estrogen receptor action through protein-protein interactions." |
12:55-1:25 p.m. | Lunch |
Afternoon |
4:00- 6:00 p.m. | Poster session II |
Evening |
6:00-7:15 p.m. | Dinner |
Session VII - Angiogenesis |
7:15-7:30 p.m. | Discussion Leader: George Stancel, University of Texas Medical School |
7:30-8:15 p.m. | Alice Levine, Mt. Sinai Hospital Medical School
"Androgenic regulation of angiogenesis in prostate cancer." |
8:15-9:00 p.m. | Salman Hyder, University of Texas Medical School
"Regulation of VEGF expression by steroid hormones and anti-hormones in uterine and breast cancer cells - A possible step towards hormonal carcinogenesis." |
9:00-9:45 p.m. | Sushanta Banerjee, University of Kansas Medical Center
"Estrogen-controlled angiogenesis in rat pituitary tumors." |
9:45-10:00 p.m. | Kathleen Bove, Stratton VA Medical Center
"Molecular mediators of angiogenesis are modulated by the fertility cycle in breast cancer." |
Morning |
7:00-8:00 a.m. | Breakfast |
Session VIII - Modeling Systems |
8:00-8:15 a.m. | Discussion Leader: Gerald R. Cunha, University of California at San Francisco |
8:15-8:55 a.m | Wayne Bucchinfuso, Eli Lilly & Company
"Estrogen receptor-a knockout and mammary tumor models." |
.
8:55-9:35 a.m. | Norman Greenberg, Baylor College of Medicine
"Transgenics and cancer: Lessons from TRAMP." |
9:35-10:15 a.m. | Jonathan J. Li, University of Kansas Medical Center
"Estrogen carcinogenesis in the hamster kidney and rat mammary gland: a common mechanism emerges." |
10:15-10:55 a.m. | Rajeshwar R. Tekmal, Emory University School of Medicine
"Aromatase transgenic mice model for breast and testicular cancers." |
10:55-11:05 a.m. | Coffee break |
11:05-11:45 p.m. | James Shull, University of Nebraska Medical Center
"Genetics of susceptibility of the ACI rat to estrogen-induced mammary carcinogenesis." |
11:45-12:25 p.m. | Robert Matusik, Vanderbilt University
"A transgenic model for prostate cancer." |
12:25-12:40 p.m. | Yuzhuo Wang, University of California
"Retinoblastoma (Rb)-knockout mouse prostatic tissue as a new model of multistage carcinogenesis." |
12:40-1:15 p.m. | Lunch |
Afternoon |
4:00-6:00 p.m. | BUSINESS MEETING |
Evening |
6:00-7:15 p.m. | Dinner |
7:15-7:30 p.m. | Elwood V. Jensen, Karolinska Institutet
"Introduction of conference addressee." |
7:30-8:15 p.m. | Shutsung Liao, University of Chicago, Ben May Institute for Cancer Research
"Charles Huggins, prostate cancer, and anomalous action of androgen." |
8:15-8:30 p.m. | Michael A. Gallo, New Jersey Medical School
"Introduction of conference addressee." |
8:30-9:15 p.m. | James D. Yager, Johns Hopkins School of Hygiene and Public Health
"Estrogen carcinogenesis: Evidence for the role of estrogen catechol
metabolites in rat liver and human breast cancer." |