SUNDAY |
2:00 pm - 9:00 pm | Arrival and check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HORMONAL THERAPIES AND CANCER RISKS |
| Discussion Leader: Robert Brueggemeier (Ohio State University) |
7:40 pm - 8:30 pm | Rebecca Jackson (Ohio State University, Columbus, OH)
"Women's' Health Initiative (WHI) trials: biomarkers and outcomes" |
8:30 pm - 9:20 pm | David Loose (University of Texas Medical School, Houston, TX)
"Quantitative aspects of gene expression in human normal and malignant endometrium" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | HORMONE BIOSYNTHESIS AND METABOLISM IN CARCINOGENESIS AND TUMOR PROGRESSION |
| Discussion Leader: Pui-Kai Li (Ohio State University, Columbus, OH) |
9:00 am - 9:45 am | Serdar Bulun (University of Illinois at Chicago, Chicago, IL)
"Mechanisms of aromatase overexpression in breast and endometrial disorders" |
9:45 am - 10:30 am | Shiuan Chen (City of Hope, Duarte, CA)
"Induction of aromatase (CYP19) expression in breast cancer cells through a
non-genomic action of ERα" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Trevor Penning (University of Pennsylvania, Philadelphia, PA)
"Beyond receptors: Hydroxysteroid dehydrogenases as targets for selective intracrine modulation" |
11:45 am - 12:30 pm | Judy Bolton (University of Illinois at Chicago, Chicago, IL)
"Metabolism of equine estrogens, estrogen quinoid chemistry/biochemistry" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW EXPERIMENTAL OR INTERVENTIONAL APPROACHES TO PREVENTION AND TREATMENT OF HORMONE-INDUCED CANCERS |
| Discussion Leader: Shuian Chen (City of Hope) |
7:30 pm - 8:15 pm | Pui-Kai Li (Ohio State University, Columbus, OH)
"Estrogen sulfatase and inhibitors in breast cancer" |
8:15 pm - 9:00 pm | Tom Burris (Eli Lilly Research Labs, Indianapolis, IN)
"Targeting estrogen receptors: coactivators and receptor selectivity" |
9:00 pm - 9:30 pm | late breaking presentation |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STRUCTURE/FUNCTION OF NUCLEAR RECEPTORS AND RECEPTOR-COACTIVATORS IN CANCER |
| Discussion Leader: Mike Gallo (Rutgers University) |
9:00 am - 9:45 am | Ann Nardulli (University of Illinois, Urbana, IL)
"Modulation of estrogen receptor conformation by estrogen response elements" |
9:45 am - 10:30 am | Ken Korach (NIEHS, Research Triangle, NC)
"Are estrogen receptors needed for hormonal carcinogenesis?" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Gerhard Coetzee (Norris Cancer Center - USC, Los Angeles, CA)
"Steroidal vs. non-steroidal signaling via the androgen receptor" |
11:45 am - 12:15 pm | late breaking presentation |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PROGRESSION FROM HORMONE-DEPENDENT TO HORMONE-INDEPENDENT MALIGNANCIES |
| Discussion Leader: Ching-Shih Chen (Ohio State University) |
7:30 pm - 8:15 pm | Wayne Tilley (Adelaide University, Adelaide, Australia)
"Androgen receptor signaling in prostate cancer progression" |
8:15 pm - 9:00 pm | Natasha Kyprianou (University of Kentucky)
"Cross-talk of TGF-beta and androgen signaling pathways in prostate cancer" |
9:00 pm - 9:30 pm | late breaking presentation |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENOMIC AND PROTEOMIC APPROACHES IN HORMONAL CARCINOGENESIS |
| Discussion Leader: Cheryl Walker (UT MD Anderson Cancer Center) |
9:00 am - 9:45 am | Cheryl Walker (University of Texas MD Anderson Cancer Center, Smithville, TX)
"Gene expression profiles in breast cancer cells" |
9:45 am - 10:30 am | Sandra Dunn (University of British Columbia, Vancouver, BC)
"Exploring the role of Akt3 in breast cancer using proteomics" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Shuk-mei Ho (University of Massachusetts Medical School, Worcester, MA)
"Gene profiling of the molecular pathways involved in prostate carcinogenesis in the testosterone plus estradiol-treated Noble rats" |
11:45 am - 12:15 pm | late breaking presentation |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ROLE OF CELL SIGNALING PATHWAYS IN PROLIFERATION AND APOPTOSIS |
| Discussion Leader: TBD |
7:30 pm - 8:15 pm | Ching-Shih Chen (Ohio State University, Columbus, OH)
"Targeting PDK-1/Akt signaling in prostate cancer" |
8:15 pm - 9:00 pm | Gail Sonenshein (Boston University, Boston, MA)
"Roles of NF-kB and Forkhead signaling pathways in proliferation and tumorigenesis" |
9:00 pm - 9:30 pm | late breaking presentation |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOVEL ANIMAL MODELS FOR RESEARCH IN HORMONES AND CANCER |
| Discussion Leader: Maarten Bosland (New York University, NY) |
9:00 am - 9:45 am | Maarten Bosland (New York University, NY)
"Introduction - update on prostate animal models" |
9:45 am - 10:30 am | Jeff Arbeit (UCSF, San Francisco, CA)
"Use of K14 promoter in transgenic mice to develop cervico-vaginal tumors" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Rajeshwar Rao Tekmal (Emory University, Atlanta, GA)
"Role of aromatase (in situ estrogen) in breast and gynecological malignancies" |
11:45 am - 12:30 pm | Jim Shull (University of Nebraska, Omaha, NB)
"Genetics of susceptibility to estradiol-induced mammary cancer in the ACI rat" |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CONFERENCE SPEAKER |
| Richard Santen (University of Virginia, Charlottesville, VA)
"Estrogens and estrogen signaling pathways in hormonal carcinogenesis" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |