Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Interpreting Human Genetic Variation
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"At The Forefront of Genomics: Making Genomic Medicine a Reality"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mapping the Regulatory Wiring of the Genome to Link Disease Variants to Functions"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Small Nuclear RNAs in Rare Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Effects of DNA Variants
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Functional Variation in the Human Genome: Insights from Population Genomics and CRISPR Perturbations"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Building an Atlas of Variant Effects for the Human Genome"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Functional Characterization and Therapeutic Targeting of Gene Regulatory Elements"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Statistical Methods and Large Datasets for Complex Trait Genetics
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Machine Learning in Personal Genomics and Disease Risk Prediction"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Biobanks and the Road Ahead in Human Genetics"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"An Epidemiological Approach to Modeling Complexity in Genetic Risk for Diverse Groups"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Imprint of Evolution on Human Genetic Diversity
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Why Does Genomic Trait Prediction Translate Poorly Across Human Ancestries?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Between-Population Genetic and Phenotypic Differences in Complex Traits"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Genomic Insights into Human Population History & Disease"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biological Mechanisms of Variant Function
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Mechanisms and Logic of Hirschsprung Aganglionosis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Using Stem Cells to Explore the Genetics Underlying Brain Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Revisiting Mendelian Disease Phenotypes: Insights from Electronic Health Records"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics in Development of Therapeutics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Humanizing Drug Discovery"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"The Genetics of Obesity: From Genes to Biology and Precision Medicine"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Explaining and Acting on a Large Number of GWAS Loci of Immune-Related Diseases by a Shared Mechanism"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Regulation in Time and Space
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"New Frontiers in Pooled Genetics Screens"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Single-Cell Epigenomics and the Regulatory Control of Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Late-Breaking Topic
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Role of Technology and Computation in Human Genetics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Complete Genomes to Pangenomes: Expanding Our Understanding of Human Haplotype Variation"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Evolution-Informed Language Models of Biological Sequences"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Modeling the Impact of Personal Genome Variation on Molecular Phenotypes"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Quantitating Disease Likelihood in Population and Opportunistic Genomic Screening"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Getting the Genome to the Clinic"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Understanding Intellectual Disability"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure