Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Hypothalamic Regulation of Physiology and Behavior
7:40 pm - 8:20 pm
"Neurobiology of Sickness and Social Behaviors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"A Novel Neural Basis for Leptin Resistance"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Neuromodulation at CRH Nerve Terminals"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"The Basis of Aggressive and Tame Behaviors in the Domesticated Silver Fox Hypothalamus"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Circuits Controlling Adaptive and Maladaptive Feeding
9:00 am - 9:20 am
"Competition Between Stochastic Neuropeptide Signals Calibrates the Rate of Satiation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"No Gain, No Pain? Hypothalamic Neurotensin Modulation of Ingestive Behavior and Pain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Early Life Food Insecurity Affects Body Weight, Food-Related Behavior, and Hypothalamic Melanocortinergic Circuit Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Developmental Programming of Neuroendocrine Integration"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Lateral Hypothalamic Control of Feeding: Implications for Obesity"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"NPY Neurons Projecting to the PVH Regulate Food Selection Under Glucoprivation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Sex and Genetic Diversity Influence Response of AgRP Neurons to High-Fat Diet and Risk for Diet-Induced Obesity"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hypothalamic Circuits Under Threat and Stress
7:30 pm - 7:50 pm
"Threat and Urgency - A Role for CRH Neurons in Tuning Innate Survival Behavior"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Role of Dorsomedial Hypothalamic Neurons in Stress Integration and Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"A Network Mechanism for State-Dependent Activity Dynamics in Hypothalamic Stress Effector Neurons"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The Role of the Hypothalamic Hypocretin/Orexin Neurons in Early Life Stress"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Anterior Hypothalamic Circuits Supporting Fear and Anxiety"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Hypothalamic Circuits for Sleep and Wakefulness
9:00 am - 9:20 am
"Sleep Regulation by the Hypothalamo-Ependymal System"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Neural Circuits Underlying the Impact of Stress on Sleep"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Modelling Sleeping Human Hypothalamus, a Metabolic Perspective"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Dialogues Between Prefrontal Cortex and Hypothalamus Regulate Sleep-Preparatory Behavior and Sleep"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Cre-Dependent Expression of P301L Mutant Tau in a Circuit for Sundowning-Related Circadian Disturbances"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Exploring Hypothalamic Pathways in Sleep Duration: New Insights from a Multi-Ancestry Genomic Approach"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Mapping the Stability of Hypothalamic Neuron Activity During Sleep and Wakefulness in Mice"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sensing and Controlling Energy Balance
7:30 pm - 7:50 pm
"Obesity Enhances Sucrose Response in Neurons of the Lateral Hypothalamus"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Effects of Weight Loss Treatments and Opioids on Hypothalamic Neurons"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Ablation of a Minor Spliceosome Component in Nkx2.1+ Progenitors Results in Hyperphagia-Induced Obesity Due to Aberrant Hypothalamic Architecture"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Novel Interoceptive Circuit from Adipose to Hypothalamus via White Adipose Tissue Nociceptive Sensory Nerves"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Neurophysiological Mechanisms of Sexual Maturation in a Mammalian Hibernator"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Hormonal Regulation of The Brain and Body
9:00 am - 9:20 am
"Hormonal Control of Brain Sex Differences"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"From Pituitary Past to Present: Pioneering into the Pituitary Immune Lanscape"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:45 am
"Visualizing the Dynamics of Neural Estrogen Response Using Colorful Tools"
10:45 am - 10:50 am
Discussion
10:50 am - 11:10 am
"The Influence of a Preclinical Mouse Model of Estrogen Gender-Affirming Hormone Therapy on the Hypothalamic Control of Metabolism"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Computational Neuroendocrinology: Linking Hormones to Behavior Through Hypothalamic Neural Activity Dynamics"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Oxytocin Signaling in Astrocytes Controls Oxytocin Expression"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Does Dysregulation of KNDy Neuron Activity Drive Menopausal Hot Flushes?"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Social Interactions From Synapses Through Computation
7:30 pm - 7:50 pm
"Hypothalamic Control of Male Sexual Behaviors in Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Roles of Hypothalamic Activity in the Regulation of Motivated Behavior"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"The Molecular Basis of Paternal Care in the African Striped Mouse Hypothalamus"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Mechanisms of the Metabolic Gate"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Genetic Dissection of Social Attachment in Prairie Voles"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Competing Demands and Motivations
9:00 am - 9:20 am
"Measuring the Impact of High-Fat Diet Composition and Content on Agouti-Related Peptide-Mediated Feeding"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"A Normative Framework Dissociates Need and Motivation in Hypothalamic Neurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"State-Dependent Connectivity and Behavioral Modulation in Interconnected GLP-1 and GLP-1R Hindbrain and Hypothalamic Circuitry"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"To Feed or Not to Feed: Hypothalamic Hunger Circuit Function in the Face of Competing Needs"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"State-Dependent Prioritization of Feeding and Parenting Behaviors"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Anatomically Distributed Neural Representations of Instincts in the Hypothalamus"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Regulation of Sociability by ‘Hunger’ Neurons During Early Development"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hypothalamic Control of Temperature and Metabolic States
7:30 pm - 7:50 pm
"A Heat Acclimation-Induced Hypothalamic Plasticity Mechanism that Drives Heat Tolerance and Resilience to Hot Environments"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"A Hypothalamic-Skeletal Muscle Pathway Regulating Glucose Metabolism and Insulin Resistance"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Modulation of Body Temperature During Pregnancy by Estrogen Signaling in Mice"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Brain Circuit for Energy Conservation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"The Role of Oxytocin Neurons of the Paraventricular Hypothalamic Nucleus in Social Thermoregulation"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure