Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cellular Senescence and Aging: The Path to Translation
7:40 pm - 8:25 pm
"The Many Faces and Impacts of Cellular Senescence"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Cellular Senescence and Senolytics: The Path to Translation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of IGF and Insulin in Metabolism and Diabetes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Plasticity in the Endocrine Pancreas as a Response to Metabolic Demand"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Ying and the Yang of ß-cell Programming"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Dietary Sugar and Protein Exert Opposing Effects on Key Growth and Metabolic Regulators in Drosophila, the Insulin and IGF1 Homologs Dilp2 and Dilp6"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Inter-Organ Communication by IGFs: Gatekeepers for Metabolic Health"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"The Nicotinamide/NAD-Sirtuin Pathway as a Target in Obesity and Metabolic Disorders"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Beta Cell Dedifferentiation and Diabetes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Homeostasis and Regeneration: Stem Cells and Cell Plasticity
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Regulation of Epithelial Cell Plasticity by IGF and Calcium Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"CRISPR Mediated Ablation of Specific IGF-1 Forms Uncovers the Importance of Glycosylation for Muscle Storage and Cleavage for Regenerative Capacity"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Paligenosis: An mTORC1-Dependent Plasticity Program Cells Use to Change Identity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Episynchrons: Translational Harnessing of the Immunoregenerative Potential of IGFBP-Derived Immodulin Peptides"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The IGF and Insulin Axis and Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Control of IGF-1 Receptor Location in Cancer Cells: A Key to Function"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
"RAGE Inhibition Halts Insulin Signals in Breast Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Function of PLK-1-IRS2 Interaction in Breast Cancer Progression"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"IGFs Regulate Tumour-Intrinsic Components of the Immune Response to Promote an Immunosuppressive Microenvironment in Prostate Cancer"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Targeting IGF/IR Signaling Enhances the Efficacy of 5FU in Colorectal Cancer Cells: A Role for IGFBP-3 and GRP78"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"The RNA-Binding Protein IGF2BP3 Modulates the Aggressiveness of Ewing Sarcoma by Dynamically Regulating IGFR Signaling"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Insulin Receptor Isoforms and Signaling in Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 12:40 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin System in Development and Aging
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Intranasal Targeting with a Potent IGF-1 Analogue to Treat Alzheimer's Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Insulin Signaling is Critical for Sinoatrial Node Maintenance and Function"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Understanding Peripheral Disturbances Following Traumatic Injury Using Drosophila"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Recognition Mechanism of IGF Binding Protein-5 by the Proteolytic Enzyme PAPP-A"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure and Activation Mechanisms of Insulin, IGF and Hybrid Receptors: Recent Advances from Cryo-EM
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Activation of the Insulin Receptor via Two Distinct Types of Sites"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Insulin Receptor Arg717 and IGF-1 Receptor Arg 704 Play Key Role in Ligand Binding and in Receptor Activation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Structural Investigations of Full-Length Insulin Receptor Dynamics and Signaling"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Cryo-EM Structure of the Complete and Ligand-Saturated Insulin Receptor Ectodomain"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Understanding the Unique Roles of the Insulin Receptor Isoforms in Breast Cancer"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"The Cone Snail Story: Current Understanding of How Insulin and IGFs Activate Their Receptors"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nutrient Sensing Related to Lifespan and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Kinase Insert Domain of Drosophila dInr Regulates Aging Through Control of Methionine Metabolism"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Mandarin Fish Ranavirus Viral Insulin/IGF-Like Peptide Inhibits Human IGF1R Phosphorylation in High Concentrations and Regulates IGF1R Gene Expression"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Alternative Splicing Regulation of Insulin Receptor in Response to Amino Acid"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Caloric Restriction and the IGF-I/IGF-1R Axis in Cancer Immunotherapy"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Targeting the IGF and Insulin Axis in the Clinic
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"What Happened to Targeting IGF-1R in Cancer?"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"IGFALS Regulates Non-Alcoholic Steatohepatitis Progression in Mouse, Organoid and Human"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Cotargeting the IGF-1/PI3K/mTOR Pathway in Ewing Sarcoma: Is the Story Over or Has it Just Begun?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Inhibition of IGF1 Receptor Signaling Improves Cardiac and Immune Functions"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Plasma Proteome of Long-COVID Patients Indicates Hypoxia Mediated Vasculoproliferative Disease Potentially Mediated by the IGF System"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"IGF-1 Receptor: Mischief Maker?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Methodologies to Advance IGF and Insulin Research
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Next Generation Nutritional and Feeding Science with Artificial Intelligence Techniques: Controlling Insulin-Like Activity by Amino Acid Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Functional Selectivity of Insulin Receptor Revealed by Aptamer-Trapped Receptor Structures"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Targeting the IGF Axis in Pediatric and Adult Glioma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Rapid Manipulation of Mitochondrial Morphology in a Living Cell with iCMM"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure