Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Systemic IGFs and The Skeleton: Revisiting and Old Story"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF and Insulin Actions in Systemic and Tissue Inflammation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Insulin and IGF-1 Effects on T Cells"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Insulin-Like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Pulmonary Neuroendocrine Stem Cells are Controlled by an Autocrine IGF-IGFBP Complex Activated by Airway Injury"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:05 am
"Changes in the Microbiota of Mice with Allergic Asthma are Partially Reversed by IGF1R Blockade"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Using Viruses to Study the Functions of IGF1 and IGF1R"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Nucleic Acid Immunity and Metabolic Homeostasis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Intraperitoneal, but not Intracerebroventricular, IGF1 Treatment Repairs Ischemic Stroke-Induced Acute Gut Damage and Improves Cognitive Behaviors in Acyclic Middle-Aged Female Rats"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin Actions in the Central Nervous System in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"IGF-I Plays a Complex Role in Amyotrophic Lateral Sclerosis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"IGF-2 as a Novel Therapeutic Candidate for Ischemic Stroke: Unveiling Its Neurogenic and Angiogenic Potential"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Cyclic Glycine Proline Regulates IGF-1 Function and its Clinical Implications in Small Vessel Diseases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"IGF1 at the Intersection of Neurodevelopment and Cancer"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Investigating the Relationship Between IGF Signaling and Amyloid Precursor Protein (APP) Processing in Prostate Cancer"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms Regulating the IGF and Insulin Signaling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"One Receptor, Many Hormones: Any Lessons from Drosophila Insulin Receptor"
9:30 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Defining Autoregulatory Roles for the IGF-1 and Insulin Receptor C-Termini in Kinase Activation"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Inter-Molecular Activation Between Insulin Receptors by a Dimeric Aptamer Agonist"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Beyond Insulin: Insulin Receptor Activators"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Structural and Functional Insights into IGF2R-Ligand Interactions: Engineering and Analysis of Extracellular Domain Constructs"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Ligands as Determinants of Specificity in Insulin Receptor-Mediated Phenotypic Regulation in C. Elegans "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exposome Impact on the IGF and Insulin Axis
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"IGF-1 Signaling: A Molecular Cascade Neglected by Endocrine Disruption Science"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:25 pm
"Environmental Stressors Across the Lifespan: The Impact on CNS Insulin/IGF-1 Signaling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Laboratory Animal Diets: Critical Variables that Affect In Vivo Research and Metabolic Disease Development"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 8:55 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Session in Memory of Dr. Valentine Macaulay : IGF and Insulin as Targets for Cancer Prevention
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Effects of Lifestyle Intervention (Mediterranean Diet and Exercise) on the IGF System and Tumorigenic Potential in Breast Cancer Survivors"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"LX-101: A Novel Approach to Targeting IGF-1R in Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Short-Term IGF Blockade Remodels Prostate Cancer Tumor Microenvironment"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Viral Insulin/IGF-Like Peptides as Novel IGF1R Inhibitors for Triple-Negative Breast Cancer"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"IGF1R Targeted NK Cell Engager Kills Proliferating and Quiescent Hormone Receptor Positive Breast Cancers"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"More than Target Practice: Resurrecting an Orphan Drug for Two Orphan Diseases"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"IGFBP-6 Regulates Progesterone Response in T47D Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Insights on the IGF and Insulin Axis Gained from Human Mutations
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Human IGF1R Insufficiency: Insights into Human Growth and Development Using Pluripotent Stem Cell Models"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"IGF Deficiency: Spectrum of Molecular Defects and Clinical Features"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Unraveling the Role of IGF2 in Silver-Russell and Temple Syndromes: The Need for Accurate Research Models"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Identification and Characterization of Functional Coding Variants in Human Longevity Pathway"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Impact of IGF and Insulin on Development and Tissue Remodeling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"The Role of Vascular Smooth Muscle Cell IGF1R in Age-Related Cerebrovascular Dysfunction"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"JUV-161: The Basis of an Investigational New Drug"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Unravelling the Paracrine Role of Endothelial IGF-1 Receptor in Mediating Favorable Gut and Adipose Tissue Remodeling in the Setting of Diet-Induced Insulin Resistance and Obesity"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Insulin, Gut Neuropeptides, and Juvenile Hormone in Drosophila Aging"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"In Vitro Models of Insulin Resistance in Adipose and Muscle Indicate Differences in Glucose Uptake Response Between IGF-II and Vesiculin"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Novel MicroRNAs Associated with Hypoxia in Fetal Hepatocytes: Potential Mechanisms Regulating Intrauterine Growth Restriction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Dissecting the Role of IGF1 from GH in the Regulation of Liver Health and Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin in Cancer
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"IRS2 Interacts with PLK1 to Regulate Mitotic Progression"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"IGF and Insulin System in Regulating Hallmarks of Cancer"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"IGFBPs Mediate Antiestrogen Activity in Breast Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"The Effect of Hyperinsulinemia and Insulin Receptor Isoforms in Triple-Negative Breast Cancer"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"The IGF-1R in Tumor Cell Adhesion and Metastasis: From Mice to Women"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure