Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Systemic IGFs and The Skeleton: Revisiting and Old Story"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF and Insulin Actions in Systemic and Tissue Inflammation
9:00 am - 9:05 am
General Discussion
9:05 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Nucleic Acid Immunity and Metabolic Homeostasis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Using Viruses to Study the Functions of IGF1 and IGF1R"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Short Talk Selected from Poster Abstracts
10:35 am - 10:40 am
Discussion
10:40 am - 11:15 am
Group Photo / Coffee Break
11:15 am - 11:40 am
"Insulin and IGF-1 Effects on T Cells"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin Actions in the Central Nervous System in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Short Talk Selected from Poster Abstracts
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"IGF-I Plays a Complex Role in Amyotrophic Lateral Sclerosis"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Cyclic Glycine Proline Regulates IGF-1 Function and its Clinical Implications in Small Vessel Diseases"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The IGF System in the Neuroendocrine Control of Metabolism"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms Regulating the IGF and Insulin Signaling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"One Receptor, Many Hormones: Any Lessons from Drosophila Insulin Receptor"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Beyond Insulin: Insulin Receptor Activators"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Ligands as Determinants of Specificity in Insulin Receptor-Mediated Phenotypic Regulation in C. Elegans "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exposome Impact on the IGF and Insulin Axis
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Quantification of Biological Aging for Translational Geroscience"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Environmental Stressors Across the Lifespan: The Impact on CNS Insulin/IGF-1 Signaling"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF and Insulin in Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Effects of Lifestyle Intervention (Mediterranean Diet and Exercise) on the IGF System and Tumorigenic Potential in Breast Cancer Survivors"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"IRS2 Interacts with PLK1 to Regulate Mitotic Progression"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"LX-101: A Novel Approach to Targeting IGF-1R in Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Progression Insights on the IGF and Insulin Axis Gained from Human Mutations
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Human IGF1R Insufficiency: Insights into Human Growth and Development Using Pluripotent Stem Cell Models"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"IGF Deficiency: Spectrum of Molecular Defects and Clinical Features"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Unraveling the Role of IGF2 in Silver-Russell and Temple Syndromes: The Need for Accurate Research Models"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
IGF and Insulin as Targets for Cancer Prevention
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"More than Target Practice: Resurrecting an Orphan Drug for Two Orphan Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"IGF1 and Cancer Risk: Evidence from Large Prospective Cohorts and Germline Genetics"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"The IGF-1R in Tumor Cell Adhesion and Metastasis: From Mice to Women"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Impact of IGF and Insulin on Development and Tissue Remodeling
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Short Talk Selected from Poster Abstracts
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"The Role of Vascular Smooth Muscle Cell Igf1r in Age-Related Cerebrovascular Dysfunction"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"JUV-161: The Basis of an Investigational New Drug"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Dissecting the Role of IGF1 from GH in the Regulation of Liver Health and Disease"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure