Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Systemic IGFs and The Skeleton: Revisiting and Old Story"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF and Insulin Actions in Systemic and Tissue Inflammation
9:00 am - 9:05 am
General Discussion
9:05 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Nucleic Acid Immunity and Metabolic Homeostasis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Using Viruses to Study the Functions of IGF1 and IGF1R"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Short Talk Selected from Poster Abstracts
10:35 am - 10:40 am
Discussion
10:40 am - 11:15 am
Group Photo / Coffee Break
11:15 am - 11:40 am
"Insulin and IGF-1 Effects on T Cells"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin Actions in the Central Nervous System in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Short Talk Selected from Poster Abstracts
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"IGF-I Plays a Complex Role in Amyotrophic Lateral Sclerosis"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Cyclic Glycine Proline Regulates IGF-1 Function and its Clinical Implications in Small Vessel Diseases"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The IGF System in the Neuroendocrine Control of Metabolism"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms Regulating the IGF and Insulin Signaling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"One Receptor, Many Hormones: Any Lessons from Drosophila Insulin Receptor"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Beyond Insulin: Insulin Receptor Activators"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Ligands as Determinants of Specificity in Insulin Receptor-Mediated Phenotypic Regulation in C. Elegans "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exposome Impact on the IGF and Insulin Axis
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Quantification of Biological Aging for Translational Geroscience"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Environmental Stressors Across the Lifespan: The Impact on CNS Insulin/IGF-1 Signaling"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF and Insulin in Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Effects of Lifestyle Intervention (Mediterranean Diet and Exercise) on the IGF System and Tumorigenic Potential in Breast Cancer Survivors"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"IRS2 Interacts with PLK1 to Regulate Mitotic Progression"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"LX-101: A Novel Approach to Targeting IGF-1R in Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Progression Insights on the IGF and Insulin Axis Gained from Human Mutations
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Human IGF1R Insufficiency: Insights into Human Growth and Development Using Pluripotent Stem Cell Models"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"IGF Deficiency: Spectrum of Molecular Defects and Clinical Features"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Unraveling the Role of IGF2 in Silver-Russell and Temple Syndromes: The Need for Accurate Research Models"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
IGF and Insulin as Targets for Cancer Prevention
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"More than Target Practice: Resurrecting an Orphan Drug for Two Orphan Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"IGF1 and Cancer Risk: Evidence from Large Prospective Cohorts and Germline Genetics"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"The IGF-1R in Tumor Cell Adhesion and Metastasis: From Mice to Women"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Impact of IGF and Insulin on Development and Tissue Remodeling
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Short Talk Selected from Poster Abstracts
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"The Role of Vascular Smooth Muscle Cell Igf1r in Age-Related Cerebrovascular Dysfunction"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"JUV-161: The Basis of an Investigational New Drug"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Dissecting the Role of IGF1 from GH in the Regulation of Liver Health and Disease"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure