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IGF and Insulin System in Physiology and Disease (GRS)

Gordon Research Seminar

Exploring the Insulin and IGF Pathway: In Silico Findings, Benchwork Discoveries and Bedside Applications

March 15 - 16, 2025

Chairs

and

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The IGF and Insulin System in Physiology and Disease GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

At the IGF and Insulin System in Physiology and Disease GRS, student and post-doctoral researchers will have the opportunity to showcase their findings and foster relationships with their peers from nearby or across the globe. Young investigators will be able to exchange ideas, establish new connections, and share their work as the next generation of scientists in our field.

Related Meeting

This GRS will be held in conjunction with the "IGF and Insulin System in Physiology and Disease" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	The Insulin and IGF Axis in Nutrition and Longevity Discussion Leader:
3:45 pm - 4:10 pm	"Nutritional Modulation of Metabolism in Diet-Induced Obesity Models"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Amino Acid Restriction Disrupts the Insulin-Like Growth Factor and Transforming Growth Factor-ß Signaling Axes in the Maternal Decidua"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Insulin and IGF Axis in Tissue Regeneration, Cancer, and Other Diseases Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Identification and Characterization of Functional Coding Variants in Human Longevity Pathway"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Changes in the Microbiota of Mice with Allergic Asthma are Partially Reversed by IGF1R Blockade"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Defining Autoregulatory Roles for the IGF-1 and Insulin Receptor C-Termini in Kinase Activation"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"Phosphoproteomics Analysis Reveals IGFBP-6 is a Regulator of Spindle Assembly in Breast Cancer Cells"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Myosin VI Regulates IGF-1R Trafficking in Pancreatic Cancer Cells"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	IGF, Insulin, and Insulin-Like Peptides in Physiology and Disease Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Viral Insulin and IGF-Like Peptides Inhibit IGF-1 Receptor Signaling to Reduce Cell Proliferation and Enhance Viral Replication"
9:25 am - 9:30 am	Discussion
9:30 am - 9:50 am	"IGF-2 as a Novel Therapeutic Candidate for Ischemic Stroke: Unveiling Its Neurogenic and Angiogenic Potential"
9:50 am - 9:55 am	Discussion
9:55 am - 10:15 am	"INS-17 is a Novel Learning and Memory-Regulating Insulin Receptor Ligand in C. Elegans"
10:15 am - 10:20 am	Discussion
10:20 am - 10:40 am	"Insulin Signaling Pathways in Corals"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Short-Term IGF Blockade Remodels Prostate Cancer Tumor Microenvironment"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: IGF Peptides and Career Advancement in Research Discussion Leader:
1:30 pm - 1:40 pm	"Unravelling the Paracrine Role of Endothelial IGF-1 Receptor in Mediating Favorable Gut and Adipose Tissue Remodeling in the Setting of Diet-Induced Insulin Resistance and Obesity"
1:40 pm - 1:45 pm	Discussion
1:45 pm - 2:05 pm	"Many Trails from PhD Onwards"
2:05 pm - 2:25 pm	Discussion
2:25 pm - 2:30 pm	General Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number 1R13DK142231-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History IGF and Insulin System in Physiology and Disease

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