Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cell Death and Inflammation
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Why So Many Ways to Die?"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Immunology of Long COVID"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Tissue Immune Interactions
9:00 am - 9:30 am
"Inflammation and Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Immunophysiology: How Immune Cells Integrate Spatially and Functionally into Organs"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"pH-Sensing by GPR65 in Tuning Systemic and Tissue Inflammation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"NINJ1 is Activated by Calcium to Mediate P2X7-Mediated Lytic Cell Death"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"The Transcription Factor NRF2 is a Master Regulator of the NLRP3 Inflammasome"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Decoding the Contribution of the Immune System to Aging"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms of Immunity
7:30 pm - 8:00 pm
"Structural and Signaling Characteristics Limiting the Efficacy of Type III IFNs and Their Potential Use as Therapeutics to Bolster Mucosal Immunity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Structural Insights into Regulation of Innate and Adaptive Immunity"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Protein Supersaturation Powers Innate Immune Signaling"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Epigenetic Regulation of Immune Responses"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Transcriptional Control of Immunoregulation"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Convergent Metabolic Signaling Dynamically REgulates Immunoglobulin Secretion"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Early Life Imprinting of Intestinal Tolerance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Unconventional T Cells Exist Within a Shared Niche and are Regulated by Purinergic Signaling"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Metabolic Adaptation of Tissue-Resident Regulatory T-Cells via Protein O-GlcNAcylation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Microbiota-Instructed Differentiation of Immune Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Immune Regulation by Microvascular Endothelial Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Nucleic Acid Sensing by Toll-Like Receptors"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Blown Apart: Mitochondrial Damage in Pyroptosis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Evolution and Mechanism of cGLR-STING Signaling in Innate Immunity"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Intracellular DNA Sensors: From Antiviral Immunity to Cancer Immunotherapy and Aging"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Multi-Faceted Regulation of Humoral Immunity"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Clonality, Specificity and Functional Features of Human Adaptive Immune Responses"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Clonal Eviction, not Deletion, is Responsible for CD8 T Cell Tolerance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Opposing Effects of Pre-Existing Antibody and Memory T Cell Help on the Dynamics of Recall Germinal Centers"
11:00 am - 11:05 am
Discussion
11:05 am - 11:35 am
"Deconvoluting Tissue-Resident Memory T-Cells in Tumors"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"LN CD8+ TRM Demonstrate Unexpected Abundance Rapid Antigen Sensing, and Biased Migration Upon Reactivation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Macrophage Checkpoint Blockade in Anti-Cancer Immunotherapy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Innate and Adaptive Lymphocytes in the Tumor MIcroenvironment"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Integrin-Deficient T Cell Leukemia Accumulates in the Central Nervous System"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Optimizing TCR-CD3 Signaling for Immunotherapy of Cancer"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Characterizing the Role of TGF-Beta Signaling in Tumoral Macrophage Behavior in Melanoma"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Stemness and Cell Cycle as Orchestrators of Immune Evasion"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Host-Microbial Interactions
9:00 am - 9:30 am
"Developmentally Regulated Thymic Expansion of Microbiota Specific T-Cells"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Directed Evolution of a Nascent Immune Pathway"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Endobiotic Glycolipid Structures of Symbionts Modulate Host Inflammatory Response via Type I Interferons"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Studying Intracellular Bacterial Infection in Hosts using Dual scRNA-Seq"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Auto-Agressive CD8 T Cells Induced by Pro-Inflammatory Monocytes Accumulate in the Lung After Clearance of SARS-CoV-2 Infection"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Influence of Fasting on Portal Venous Immune Pools and its Reversal by SFB-Th17 Responses"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Informing Vaccine Design by Defining the Rules of Antibody Responses"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Dissecting the Interleukin-17 Pathways in the Brain that Control Animal Behaviors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuro-Immune Communications
7:30 pm - 8:00 pm
"Neuroimmune Interactions Shaping Social Behavior"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Cutaneous Pain-Triggering Interventions Engage a Cellular Mechanism that Promotes Hair Growth and Restoration After Wounding"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Regulation of CNS Inflammation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Molecular Mechanisms in Neurodegeneration"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure