Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Immunoengineered Medicine
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Materials and Protein Engineering to Counter Inflammation and Autoimmunity"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Novel Receptors for T Cell Engineering that Overcome Cancer Heterogeneity"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering the Aging Immune System
9:00 am - 9:25 am
"Understanding the Building Blocks of Immune Aging to Engineer Effective Immune Responses"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Understanding Immune Aging at a Single-Cell Resolution"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Theraparticles for Inside-Out Neutrophil Control in Acute Inflammation"
11:05 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Self-Tolerance and Immunoregulation After Traumatic Soft Tissue Injury"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Aged Microenvironment Impairs BCL6 Induction in CD4+ T Follicular Helper Cell Differentiation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Cell Mitochondrial Variant Enrichment Resolved Clonal Tracking and Spatial Architecture in Human Embryonic Hematopoiesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Regenerative Immunoengineering
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Leveraging Biomaterials for Preclinical Models of Therapeutic Response and Disease Development"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
"Sponge-Like Microneedles Sequester Chemokines and Deplete Monocytes to Relieve Chronic Skin Inflammation"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"A Human iPSC-Derived Isogenic Model of the Neurovascular Unit to Explore Blood-Brain Barrier Dysfunction in Neuroinflammation"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Bionic Macrophages for Regenerative Medicine"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tissue Immunity and Models
9:00 am - 9:25 am
"Modeling Blood-Brain Barrier Immune Interactions In Vitro"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Organ-On-Chip Models of the Lymph Node After Vaccination"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Engineered Small Scale Systems for Immunology: From Cell Biology to Clinical Trials on a Chip"
11:05 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Biomaterials for Immune Acceptance"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Integration of Nanotechnology into Tissue Scaffolds for Immunomodulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Engineering Innate Immunology in a Humanized, Functional, In Vitro Model of Healthy Myocardium"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neuroimmunology and Immunometabolism
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Mechanism for Loss of Treg Function in Human Autoimmune Disease"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
"Immunometabolism Modulation Using Biomaterials to Generate Immunotherapies"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Design of Synthetic Peptides for Vaccination Against Neurodegenerative Diseases"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Engineering Metabolic Sufficiency in Therapeutic T Cells"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunoengineered Cell Therapies For Cancer
9:00 am - 9:25 am
"Development of Synthetic T Cell States for Adoptive Therapy"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Engineering Metabolically Fit, Memory-Rich CAR T Cells for Treatment of Cancer"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Engineering Immune Cell Specificity Towards Aberrant Glycosylation"
11:05 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Engineering T Cell Specificity for Cancer Immunotherapy"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Implantable CAR T Cell Biofactories"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"T Cell Circuits that Sense Antigen Density for Cancer Immunotherapy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathogen Systems Immunology and Sensing
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:40 pm
"Integrated Organ Immunity"
6:40 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Unlocking Serology’s Secrets: Harnessing Novel Immune Biomarkers to Predict Lyme Disease Progression and Recovery"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The Hierarchical Organization Driving Pathogen-Host Interactions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Immunoengineering Pathogens
9:00 am - 9:25 am
"Regulation of Host-Microbial Interactions in Homeostasis and Disease"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Mapping Uncharted Landscapes of Host-Microbiota Communication"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Nanomaterials for Controlled Immunomodulation During Pathogenic Infection"
11:05 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Engineering Nanoparticle Systems to Target Lmphatic Transport and Deciphering Underlying Cellular Mechanisms"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Delivery of STING Pathway Inhibitors as a Platform for Treatment of Ulcerative Colitis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Engineering the B Cell Response to Skin Bacteria as Vaccines"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular and Systems Immunoengineering in Cancer
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Systems Biology Modeling of the Tumor-Immune Ecosystem"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
"Rapid Engineering of Soluble T Cell Receptors for Enhanced Affinity Via a High-Throughput Yeast-Based Platform"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Using Artificial Intelligence to Rationally Design T Cell Vaccines and Therapeutics"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Engineered Cytokine-Antibody Fusion Proteins to Advance Immunotherapy"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure