Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Evolution of IDPs and Function
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"The Fuzzy Protein Theory"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Path from Ancestral Polypeptide Disorder to Autonomous Protein Folding"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"IDPs and the Evolution of the Genetic Code and Disordered Domains"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emergent Properties of Disordered Ensembles
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Highly Disordered Biomolecular Complexes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Impact of Fuzzy Appendages and of Pre-Configuration in Partner Recognition by an IDP"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Self Assembly of IDPs: Membraneless Organelles and Amyloid"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein Using NMR Spectroscopy"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Cross-Linking/Mass Spectrometry to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Tardigrades Use Disordered Proteins to Survive Desiccation"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Physical Basis of Phase Transitions in Cells
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Integrating Single Chain Conformational Fluctuations into a Stickers and Spacers Model for Phase Behavior of IDPs"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"Reentrant Liquid Condensation of Low-Complexity RNA-Binding Motifs"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Profilin Binding Modulates Aggregation and Phase Separation of Huntingtin N-Terminal Fragments via Polyphasic Linkage"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Design Principles to Encode Aqueous Phase Behavior in Intrinsically Disordered Peptide Polymers"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Interactions with IDPs and Transport
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Single-Molecule Biophysics of Complexity in IDP-Membrane Interactions"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Intrinsically Disordered Proteins as Stochastic Drivers of Membrane Remodelers"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"The Role of IDP-Membrane Interactions in Neurotransmission and Neurodegeneration"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Dynamics and Disorder in the Nuclear Pore Complex"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"IDPs and Membranes: A Fat Chance?"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ensembles and Conformational Dynamics of IDPs
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Finding Functions of Dysfunctional Proteins"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"Plasticity and Dynamics of Intrinsically Disordered Proteins: Combining Fluorescence and NMR Spectroscopy"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Structural Dynamics of Homo-Repeat Regions in Huntington"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Disordered Regions in Ensemble and Fold Switching"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IDP Interactions and Allosteric Regulation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Coupled Folding and Binding in Transcription"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Toxin-Antitoxin Modules as a Model for Functional Intrinsic Disorder in Bacteria"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Regulating Protein Function via Structure-Disorder Interactions"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Coupled Binding and Folding Interactions: Mechanistic and Evolutionary Aspects"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"The Role of Intrinsic Disorder in Microtubule Regulation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Disorder in Transcriptional Control"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Post-Translational and Ligand-Dependent Regulation of IDP Function
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Specific Regulation of the 20S Proteasome Complex and the Impact on IDPs Cellular Levels"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"Protein Disorder in Regulation of Large Dynamic Assemblies Associated with Motility, Transcription and Viral Replication"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Molecular Defect in ALS Mutant FUS-RNA Interaction Drives Aberrant Phase Separation and Cellular Aggregation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Multisite Phosphorylation of Disordered Proteins in Cell Cycle Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Role of IDPs in Membrane-Less Organelles
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Phase Separation: Molecular Interactions, Biochemical Function and Disease"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Viral Factories Formed During Rabies Virus Infection Are Membrane-Less Liquid Organelles"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Protein Phase Separation as a Stress Survival Strategy"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
"Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"TAR DNA-Binding Protein 43 (TDP-43) Liquid-Liquid Phase Separation Is Mediated by Just a Few Aromatic Residues"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Recapitulation of Selective Nuclear Transport by Phase-Separation with a Repetitive 12-mer Peptide"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Decoding Molecular Plasticity in the Dark Proteome of the Nucleocytoplasmic Transport Machinery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: The Role of IDPs in Function and Disease
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:35 pm
"The Many Biological Faces of IDPs"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Function of IDPs in Regulation of Cellular Signaling Pathways"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Study of the YAP:TEAD Interface"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure