Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Sensing Through Disorder
3:15 pm - 3:50 pm
"Disordered Sensing: From Basic Principles to De Novo Sensor Design"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Theory and Application of Disordered Sequences
5:30 pm - 5:40 pm
"Unexpected Energetics in the Transition State Ensemble for Folding and Binding of an Intrinsically Disordered Short Linear Motif to a Folded Domain"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Towards Rational IDP Drug Design with Ensemble-Based Pharmacophore Analyses"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"The Impact of Multiple Attractions on Liquid-Liquid Phase Separation"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"DNA Binding Redistributes Activation Domain Ensemble and Accessibility in Pioneer Factor Sox2"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"X-Ray Footprinting as a Strategy to Identify Intra- and Intermolecular Contacts of Intrinsically Disordered Proteins at Single-Residue Resolution"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Interdomain Interaction Through Structural Disorder in Nuclear Receptors"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Characterization of pH-Induced Distinct Conformations of β2 -Microglobulin"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"The Role of Aromaticity in the N-Terminal Region of alpha-Synuclein from Molecular Simulations"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emergent Properties of IDRs: Assemblies and Systems
9:00 am - 9:10 am
"Liquid-Liquid Phase Separation of a Post-Translational Modifier SUMO1 Protein Driven by its Structured Part"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Correlating the Ensembles of Transcriptional Activation Domains with Gene Expression Levels"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Discovering Functionally Similar Disordered Proteins by Generic Sequence Features"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Nuclear Speckle Proteins with RNA Recognition Motifs Form Intrinsic and RNA-Dependent Microphases"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Development of Condensate Inducer to Treat Osteoarthritis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Connecting Molecular Dynamics and Tissue Mechanics Through the Material Properties of the Nucleoplasm"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"The Arabidopsis SOG1 Interactome Varies with its Phosphorylation-Dependent Transcriptional Activity"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Cosolutes Tune the Structure and Function of Desiccation Tolerance IDPs"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating the Funding Landscape
1:30 pm - 2:30 pm
Panel Discussion
Funding Insights in the Biophysical and Biological Sciences
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes