Sunday 9th, evening
7:30-9:30 pm | Cl channels ("the poor/pore cousins"?) |
discussion leader - Chris Miller
- Merritt Maduke: "Low Resolution Structure and Function Studies of a ClC Chloride Channel"
- Christoph Fahlke: "Ion permeation and selectivity in ClC-type chloride channels"
- Michael Pusch: "Double barreled structure of muscle chloride channels"
- Tsung-Yu Chen (10 min) "Pore stoichiometry of ClC-0: a view from outside"
Monday 10th, morning
9:00 am-12:30 pm | Pore properties |
discussion leader - Fred Sigworth
- Rod MacKinnon (A.M. Cruickshank Lecture): "Potassium Channel Structure and Function"
- Jian Yang: "Ion Permeation and Gating in an Inward Rectifier Potassium Channel"
- Zhe Lu: "Properties of inward rectification"
- Gary Yellen: "The gate(s) of the voltage-gated K+ channels"
- Lise Heginbotham: "Ion permeation and blockade of the KcsA K+ channel"
Monday 10th, evening
7:30-9:30 pm | Permeation models |
discussion leader - Olaf Andersen
- Olaf Andersen: "Ion permeation through a single-filing channel"
- Bob Eisenberg: "Selectivity in L type Ca channels: Excluded Volume and Electrostatics"
- Shin-ho Chung: "Mechanisms of Permeation and Selectivity in Calcium Channels: Brownian Dynamics Studies"
- Benoit Roux: "Permeation of potassium in the KcsA channel: A molecular dynamics study"
Tuesday 11th, morning
9:00 am-12:30 pm | Mechanisms of gating |
discussion leader - Clay Armstrong
- Fred Sigworth: "EM methods for channel structure determination"
- Niko Grigorieff: "Three-dimensional Structure of the Shaker Potassium Channel"
- Dick Horn: "Immobilizing the Moving Parts of Voltage-Gated Ion Channels"
- Pancho Bezanilla: "Conformational changes during voltage sensing"
- Eduardo Perozo: "Structure of KcsA inner helical bundle in the open state"
Tuesday 11th, evening
7:30-9:30 pm | Ligand gated channels |
discussion leader - Steve Siegelbaum
- Tony Auerbach: "Mechanisms of gating of acetylcholine receptor channels"
- Fred Sachs: "Gating and permeation in P2X2 channels"
- Baljit Khakh: "State-dependent cross-inhibition between transmitter-gated cation channels"
- Juan Korenbrot: "Selectivity and modulation of cGMP-gated channels make the world colorful"
Wednesday 12th, morning
9:00 am-12:30 pm | Channel regulatory proteins |
discussion leader - Bertil Hille
- Fran Ashcroft: "Gating of the KATP channel and its modulation by the sulphonylurea receptor subunit"
- Jacqui Gulbis: "The cytoplasmic assembly of voltage-gated (Kv1) Potassium channels"
- Steve Ikeda: "Probing the Role of RGS proteins in Ion Channel Modulation using mutant G protein subunits"
- David Yue: "Calmodulation of voltage-gated calcium channels"
- Eitan Reuveny: "Identification of the Gbeta-gamma-dependent gating element in GIRK"
- Sergei Sukharev: "The gating transition of the large mechanosensitive channel, MscL"
Wednesday 12th, evening
7:30-9:30 pm | Channel assembly & trafficking |
discussion leader - Carol Deutsch
- Blanche Schwappach: "Using dominant trafficking approaches to study membrane protein assembly"
- Diane Papazian: "Biogenesis and structural organization of the voltage sensor in potassium channels"
- Paul Pfaffinger: "The role of the T1 domain in voltage-dependent potassium channel assembly and function"
- Dan Minor: "Links between the polar T1 interface and Kv channel gating"
Thursday 13th, morning
9:00 am-12:30 pm | Channels in disease |
discussion leader - David Clapham
- Alan Finkelstein: "Protein translocation associated with channel gating"
- Matt Nolan and Alexei Morozov: "Combined genetic and physiological approach to the S H-current function in Hippocampus"
- Colin Nichols: "Nucleotide sensitivity of KATP channels and the genetic basis of insulin secretory diseases"
- Tzyh-Chang Hwang: "Gating of the CFTR Chloride Channel by ATP Hydrolysis"
- Laszlo Csanady: "Severed channels probe regulation of gating of CFTR by its cytoplasmic domains"
- Erika S. Piedras-Renteria: "Effects of the deletion of the alpha1A calcium channel"
Thursday 13 th, evening
7:30-9:30 pm | Keynote address: |
- Clay Armstrong: "Ion Occupancy and Channel Gating"
- Bertil Hille: "Reflections"
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