Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Ion Channels in Human Health and Disease
Discussion Leader: Janice Robertson (Washington University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Jue Chen (Howard Hughes Medical Institute / Rockefeller University , United States)
"Molecular Mechanisms Underpinning Cystic Fibrosis Pathology and Pharmacology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Yasushi Okamura (Graduate School of Medicine, Osaka University, Japan)
"Spying Chats with PIs: VSP and Light"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Kallol Gupta (Yale University, United States)
"Nanoscale Molecular Cartography of the Cellular Membrane"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Ion Channel Functional Complexes
Discussion Leader: Gail Robertson (University of Wisconsin-Madison, United States)
9:00 am - 9:20 am
Fernando Santana (University of California, Davis, United States)
"The Structural and Functional Role of KV 2.1 Channels in Arterial Smooth Muscle"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Show-Ling Shyng (Oregon Health and Science University, United States)
"Dynamic Duo: Kir6 and SUR in KATP Channel Structure and Function"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Roderick MacKinnon (Rockefeller University / Howard Hughes Medical Institute, United States)
"GPCR to Channel Communication in a Membrane Signaling Pathway"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stephan Pless (University of Copenhagen, Denmark)
"Not Alone: Examples of how Protein-Protein Interactions Alter Ion Channel Function to Shape Neuronal Excitability"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Monika Vig (Tata Institute of Fundamental Research, India)
"SNAPing and SNAREing Ion Channel Pore Subunits For Functional Assembly"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Claudia Moreno (University of Washington, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Calcium Signaling
Discussion Leader: Henry Colecraft (Columbia University, United States)
7:30 pm - 7:50 pm
Seok-Yong Lee (Duke University School of Medicine, United States)
"Molecular Mechanism of TRPM8 Gating"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Wei Lü (Van Andel Institute, United States)
"Temperature-Dependent Ligand Recognition and Gating in TRPM4"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Candice Paulsen (Yale University, United States)
"Sight Unseen: Uncovering a Critical Role for Calmodulin in TRPA1 Calcium Regulation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Vivian Gonzalez-Perez (Washington University in St. Louis, United States)
"The Role of LRRC26-Containing BK Channels in Colonic Epithelial Secretory Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Philippe LORY (CNRS - Universite Montpellier, France)
"Deciphering how the Gate-Modifying Mutations in Cav3.1 T-type Calcium Channels Causing Neurodevelopmental Disorder (SCA42ND) Promote Enhanced Ca2+ Entry"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Voltage-Gated Ion Channels and Cellular Excitability
Discussion Leader: Kenton Swartz (National Institutes of Health, United States)
9:00 am - 9:20 am
Daniel Minor (University of California, San Francisco, United States)
"Electrosomes: Some Assembly Required"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rene Barro Soria (University of Miami, United States)
"The KCNQ2 Channel Opens with a Minimum of One Voltage Sensor Activation."
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Susy Kohout (Cooper Medical School of Rowan University, United States)
"Atypical Control of Voltage-Dependence and Enzyme Activity in VSP"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Shubhangi Agarwal (Weill Cornell Medicine, United States)
"Ball-and-Chain Inactivation in Calcium and Voltage Activated Potassium Channel, hSlo1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Angelika Lampert (Uniklinik RWTH Aachen, Germany)
"Sodium Channels and Nociceptor Subclasses as Identified by PatchSeq"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Sandipan Chowdhury (University of Iowa, United States)
"Assembly of SLO Channels with Gamma Subunits"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Oscar Vivas (University of Washington, United States)
"On the Mechanisms of BK Channel Clustering"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Cathy Proenza (University of Colorado School of Medicine, United States)
"Intracellular Ca2+ Causes HCN4 Channels to Desensitize to cAMP"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Negative Ion Channels
Discussion Leader: Alessio Accardi (Weill Cornell Medicine, United States)
7:30 pm - 7:50 pm
Tingting Yang (Columbia University, United States)
"Bestrophins: Structure, Function and Diseases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Huanghe Yang (Duke University School of Medicine, United States)
"Yin and Yang of Ion and Lipid Transport"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Randy Stockbridge (University of Michigan, United States)
"Mechanisms of Fluoride Export"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Rajan Sah (Washington University in St. Louis, United States)
"SWELL Ion Channels LRRCing in Platelets"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ligand Activation of Ion Channels and Synaptic Transmission
Discussion Leader: Andrew Plested (Humboldt University of Berlin, Germany)
9:00 am - 9:20 am
Radu Aricescu (MRC Laboratory of Molecular Biology, United Kingdom)
"The Wide Wild World of Human GABAA Receptors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Matt Trudeau (University of Maryland School of Medicine, United States)
"Mechanisms of PAS Domain Regulation in hERG K Channels"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Laetitia Mony (Institute of Biology, Ecole Normale Supérieure, INSERM, CNRS, France)
"GluD1 Binds GABA and Controls Inhibitory Synaptic Plasticity"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Susanne Mesoy (Kavli Institue for Nanoscience Discovery / University of Oxford, United Kingdom)
"Measuring Lipid Modulation of Ion Channel Function in Live Cells"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Alexander Sobolevsky (Columbia University, United States)
"Gating and Regulation of Ionotropic Glutamate Receptors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Anna Moroni (University of Milan, Italy)
"Isolation and Functional Validation of Subtype-Specific Nanobodies for HCN Channels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Polina Lishko (Washington University in St. Louis, School of Medicine, United States)
"The Role of Kir7.1 Ion Channel in Vision and Reproduction"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Channels and Drug Discovery
Discussion Leader: Merritt Maduke (Stanford University, United States)
7:30 pm - 7:50 pm
Brad Rothberg (Temple University Lewis Katz School of Medicine, United States)
"Structure and Function of an ATP-Sensing Channel from Mycobacteria: A Potential Drug Target for TB"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jun Chen (Genentech, United States)
"Unlocking TRPA1: Activation, Inhibition and Clinical Prospects"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Valeria Vásquez (University of Texas Health Science Center, United States)
"Using Dietary Fatty Acids to Modulate PIEZO Channels"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Y. Lyna Luo (Western University of Health Sciences, United States)
"Leveraging PIEZO Channel's Mechano-Electrical Coupling for Rational Drug Design"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanosensation and Lipid Regulation
Discussion Leader: Crina Nimigean (Weill Cornell Medicine, United States)
9:00 am - 9:20 am
Medha Pathak (University of California, Irvine., United States)
"Optical Measurements of Piezo1 in Native Cellular Conditions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Eric Gouaux (Vollum Institute / Howard Hughes Medical Institute Inc, United States)
"C. elegans TMC-1 Complex Informs Architecture and Mechanism of the Auditory Mechanosensory Transduction Channel"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Amanda Lewis (Duke University, United States)
"Piezo1 Ion Channels are Capable of Conformational Signaling"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Charles Cox (VCCRI, Australia)
"Lipidation Regulates a PIEZO Channel Complex"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Bailong Xiao (Tsinghua University, China)
"Forcing PIEZO Channels to Open"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tibor Rohacs (Rutgers - New Jersey Medical School, United States)
"Regulation of PIEZO2 Channels by Membrane Phospholipids"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sampurna Chakrabarti (Max Delbrück Center for Molecular Medicine, Germany)
"New Proteins in Pain and Touch: Elkin1 and Beyond"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jerome Lacroix (Western University of Health Sciences, United States)
"Cooperative Modulation of PIEZO1 Channels"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Approaches in Ion Channels
Discussion Leader: Chris Ahern (University of Iowa, United States)
7:30 pm - 7:50 pm
Julia Gorelik (Imperial College London, United Kingdom)
"Functional Localization of LTCCs in Cardiomyocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Venkata Shiva Mandala (Rockefeller University, United States)
"Molecular Mechanisms of Voltage Sensing in Kv Channels"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Stephen Long (Memorial Sloan Kettering Cancer Center, United States)
"Mechanisms of Ion Selectivity in the Mitochondrial Calcium Uniporter"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Eric Mulhall (Scripps Research, United States)
"Exploring the Structural Mechanics of PIEZO Ion Channels with Fluorescence Nanoscopy"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Huan Bao (University of Virginia, United States)
"Designer Nanodiscs to Probe Membrane Biology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Fred Sigworth (Yale University, United States)
"CryoEM Pursuit of a Kv1 Closed-Channel Structure"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure