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Ion Channels (GRS)

Gordon Research Seminar

Excitable Membranes in the Era of Precision Biology

July 7 - 8, 2018

Chairs

and

Mount Holyoke College

50 College Street

South Hadley, Massachusetts, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Ion Channels is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange ideas.

At this meeting, the latest research unveiling the evolution, function and modulation of ion channels will be presented and discussed by early career researchers. Attendees will also benefit from sessions with senior scientists, including keynote speaker Shai Silberberg from the NIH, aimed at career development and approaches to research.

Related Meeting

This GRS will be held in conjunction with the "Ion Channels" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Rigor and Transparency Discussion Leader:
3:45 pm - 4:15 pm	"Rigor and Transparency"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Ion Permeation and Channel Gating / Dynamic Selectivity Filters Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader: Ion Permeation and Channel Gating
7:35 pm - 7:50 pm	"Structure of a Volume-Regulated Anion Channel of the LRRC8 Family"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"Mechanism of TRPV5 Modulation and Gating as Revealed by Cryo-EM"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Cryo-EM Structures Reveal the Mechanism of Bestrophin Ca²⁺ Dependent Gating"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:35 pm	Introduction by Discussion Leader: Dynamic Selectivity Filters
8:35 pm - 8:50 pm	"The Role of the Selectivity Filter in TRPV1 Channel Gating"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"A Single NaK Channel Conformation Is Not Enough for Non-Selective Ion Conduction"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"Outward Rectification in a Viral Potassium Channel Is Based on Ion Depletion of the Selectivity Filter"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Ligand-Induced Gating / Allosteric Coupling Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader: Ligand-Induced Gating
9:05 am - 9:15 am	"Structure-Guided Design of Synthetic Peptides for Orthogonal Control of HCN Channels"
9:15 am - 9:20 am	Discussion
9:20 am - 9:30 am	"Auxiliary Subunits Keep AMPA Receptors Compact During Activation and Desensitization"
9:30 am - 9:35 am	Discussion
9:35 am - 9:50 am	"Using FRET to Disentangle Nucleotide Binding Effects on KATP"
9:50 am - 9:55 am	Discussion
9:55 am - 10:00 am	Introduction by Discussion Leader: Allosteric Coupling
10:00 am - 10:10 am	"Molecular Mechanisms of VSD-Pore Coupling of IKs Channels"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Key Residues in the Interface Between Voltage Sensor and Pore Domain in Shaker"
10:25 am - 10:30 am	Discussion
10:30 am - 10:45 am	"Mapping and Harnessing Allosteric Potential in Ion Channels Through Saturated Domain Insertion Profiling"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Activating Your Career: Pathways and Mechanisms Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Activating Your Career: Pathways and Mechanisms
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS106929. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Ion Channels

July 12 - 17, 2026

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