Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Allostery-Hemoglobin and Channels
Discussion Leaders: Paula Bender (The University of Texas Health Science Center at Houston , United States) and Lisandra Flores-Aldama (University of Wisconsin-Madison, United States)
3:45 pm - 4:25 pm
Vasanthi Jayaraman (University of Texas Health Science Center at Houston, United States)
"Allostery-Hemoglobin and Channels"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Channels as Physiological Signal Integrators
Discussion Leaders: Eric Gibbs (Case Western Reserve University, United States) and Jenna Lin (Washington University in St. Louis, United States)
7:30 pm - 7:40 pm
Tatiana Laboure (Institut de Biologie Structurale, France)
"Structure of a Honeybee GABAA Receptor"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Susanne Mesoy (Kavli Institue for Nanoscience Discovery / University of Oxford, United Kingdom)
"Measuring Lipid Modulation of Ion Channel Function in vivo "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Sean Burke (University of California, San Diego, United States)
"Structural Mechanisms of a7 Nicotinic Receptor Allosteric Modulation and Activation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Rebeca Martinez-Lazaro (University of La Laguna, Spain)
"Pathophysiology of BK-NMDAR Complexes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Veronika Linhart (Linköping University, Sweden)
"Investigating Estradiol’s Role in KV 7.1/KCNE1 Channel Regulation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Ryan Mahling (Columbia University, United States)
"De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Mae Weaver (University at Buffalo, United States)
"Dynamic Ca2+ Permeability of the NMDA Receptor in Response to Endogenous and Synthetic Modulators"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Roberta Castelli (University of Milan, Italy)
"An HCN4 Specific Nanobody for the Modulation of Pathogenic Channels"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Ion Channel Regulation
Discussion Leaders: Tharaka Wijerathne (Western University of Health Sciences, United States) and Rachel Kaye (University of Oxford, United Kingdom)
9:00 am - 9:10 am
Anna Koster (Scripps Research Institute, La Jolla, United States)
"Chemical Mapping of Protein Networks that Sense Cellular Force: a Mass Spectrometry-Based Approach to Survey the Molecular Neighborhood of the PIEZO1 Ion Channel at the Cell Surface"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Marie Cronin (Duke University, United States)
"Non-Canonical Modulation of Mechanosensitive Piezo Ion Channels"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Ruitao Jin (Australian National University, Australia)
"Mechanism of Mechanical Activation of OSCA Channels Revealed Using Cryo-EM and Advanced Unbiased Simulations"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
George Vaisey (Rockefeller University, United States)
"Piezo1 Mechanosensation in Cell-Derived Membrane Vesicles"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Gabriella Bertaccini (University of California, Irvine, United States)
"Visualizing PIEZO1 Localization and Activity From Single Cells to Tissue Organoids Using PIEZO1-HaloTag hiPSCs"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Guillaume Audic (Inserm U1216 , France)
"Elucidating the Structural Basis for Ligand Binding and Translocation in Conserved Insect Odorant Receptor Co-Receptors"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Sacha Salphati (University of Oxford / University of Pennsylvania, United States)
"Developing Novel Strategies to Engineer Sybodies for In Situ Studies of Channels"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Daniel Orlin (Oregon Health and Science University, United States)
"Examining the Role of TMEM63B in C-LTMRs"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Realities of Scientific Careers
Discussion Leader: Alicia De la Cruz (Linköping University, Sweden)
1:30 pm - 2:30 pm
Panel Discussion
Multiple Scientific Pathways and Careers
Henry Colecraft (Columbia University, United States)
Shivani Ahuja (Reed College, United States)
George Kwabena Umanah ( National Institute of Neurological Disorders and Stroke, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes