| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Speaker |
| 3:45 pm - 4:15 pm | Vern Schramm (Albert Einstein College of Medicine)
"Isotope effects in binding, catalysis and dynamics"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Isotope Effects on Chemical Reactions |
| Discussion Leader: Samae Quijano (Texas A&M University) |
| 7:30 pm - 7:50 pm | Anna Pabis (Technical University of Lodz)
"Theoretical Determination Of The Kinetic Isotope Effects For The Oxidative Degradation Of Nitrobenzene Catalyzed By Nitrobenzene Dioxygenase"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Ivonne Andujar-de Sanctis (Texas A&M University)
"Structural effects on Newtonian Kinetic Isotope Effects"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Kin-Yiu Wong (Rutgers, The State University of New Jersey)
"Characterization of the Reaction Path and Transition States for RNA Transphosphorylation Models from Kinetic Isotope Effects"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Pawel Adamczyk (Technical University of Lodz)
"Theoretical Evaluation of Isotopic Fractionation Factors in Oxidation Reactions of Aromatic Pollutants"
|
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Isotope Effects on Enzymatic Reactions |
| Discussion Leader: Tatiana Mishanina (University of Iowa) |
| 9:00 am - 9:20 am | John Robbins (Auburn University)
"Solvent and Primary Kinetic Isotope Effects on the Desulfonation Mechanism of the Two-Component Alkanesulfonate Monooxygenase System"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Daniel Roston (University of Iowa)
"Conformational Distributions at the 'Tunneling Ready State' of H-Transfers"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Swathi Gannavaram (Georgia State University)
"Kinetic Determination of Redox Potential for Flavin Reduction in D-Arginine Dehydrogenase"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Muhammad Saeed (University of Iowa)
"Targeting thymidylate synthase activity and folate receptors expression to assess therapeutic response and cancer imaging by positron emission tomography (PET) technique" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Probing Enzyme Dynamics Using Isotope Effects |
| Discussion Leader: Emannuel Burgos (Albert Einstein College of Medicine) |
| 1:30 pm - 1:50 pm | Randy Kipp (Albert Einstein College of Medicine)
"Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Rafael Da Silva (Albert Einstein College of Medicine)
"Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme"
|
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
