Session 1:
Sunday PM, January 28 | Structure and Gating of Mechanosensitive Channels |
|
| Discussion Leader: Ching Kung |
| 7:30-7:45 PM | Ching Kung (University of Wisconsin) |
| 7:45-8:10 PM | Sergei Sukarhev (University of Maryland)
"The Gating Transition of the Large Mechanosensitive Channel MscL" |
| 8:10-8:20 PM | Discussion |
| 8:20-8:45 PM | Richard Walker (University of California, San Diego)
"Mechanosensitive Channels" |
| 8:45-8:55 PM | Discussion |
| 8:55-9:20 PM | Paul Blount (University of Texas Southwestern Medical School)
"Mechanosensitive Channels in Bacteria: Genetics, Protein Structure, and Physiology" |
| 9:20-9:30 PM | Discussion |
Session 2:
Monday AM, January 29 | Structure and Conformational Changes of 7 TM Receptors |
|
| Discussion Leader: Thue Schwartz (University of Copenhagen) |
| 9:00-9:15 AM | Thue Schwartz (University of Copenhagen) |
| 9:15-9:40 AM | Dieter Oesterhelt (Max Planck, Martinsried, Germany)
"Structure and Function of Halorhodopsin" |
| 9:40-9:50 AM | Discussion |
| 9:50-10:15 AM | Sriram Subramaniam (National Cancer Institute)
"Atomic Resolution Model for Protein Conformational Changes in Bacteriorhodopsin Derived from Electron Microscopic Analysis of Two-Dimensional Crystals" |
| 10:15-10:25 AM | Discussion |
| 10:25-10:40 AM | Andrei Lomize (University of Michigan)
"Comparative modeling of non-homologous GPCRs" |
| 10:40-10:50 AM | Discussion |
| 10:50-11:20 AM | Coffee Break & Picture |
| 11:20-11:45 AM | Edward Hulme (Medical Research Council, Mill Hill, UK)
"Ligand Recognition and Activation of Muscarinic Acetylcholine Receptors" |
| 11:45-11:55 AM | Discussion |
| 11:55-12:20 PM | Masashi Miyano (Riken Harima Institute at Spring-8, Japan)
"Crystal Structure of Bovine Rhodopsin: Implications for the Activation Mechanism"
|
| 12:20-12:30 PM | Discussion |
| 12:30-1:30 PM | Lunch |
| 1:30-4:00 PM | Free |
| 4:30-6:00 PM | Poster Session |
| 6:00-7:00 PM | Dinner |
| 7:30-9:30 PM | Session 3 |
Session 3:
Monday PM, January 29 | Aquaporins |
|
| Discussion Leader: Jim Hall |
| 7:30-7:45 PM | Jim Hall (University of California, Irvine) |
| 7:45-8:10 PM | Robert Stroud (University of California, San Francisco)
"Structure of a Glycerol Conducting Channel and the Basis for Its Selectivity" |
| 8:10-8:20 PM | Discussion |
| 8:20-8:45 PM | Bing Jap (Lawrence Berkeley Lab)
"Structure and Function of Aquaporin" |
| 8:45-8:55 PM | Discussion |
| 8:55-9:20 PM | Daniel J. Mueller (Biozentrum, Basel)
"Observing Conformation, Interaction, and Assembly of Membrane Proteins by Atomic Force Microscopy" |
| 9:20-9:30 PM | Discussion |
Session 4:
Tuesday AM, January 30 | Molecular Dynamics Simulations of Membrane Proteins |
|
| Discussion Leader: Don Engelman |
| 9:00-9:15 AM | Don Engelman (Yale University) |
| 9:15-9:40 AM | Mark Sansom (Oxford University)
"Ion Channel Gating Explored by Molecular Modeling and Simulation" |
| 9:40-9:50 AM | Discussion |
| 9:50-10:15 AM | Benoit Roux (Cornell University)
"Molecular Dynamics Simulations of the KcsA Potassium Channel" |
| 10:15-10:25 AM | Discussion |
| 10:25-10:40 AM | Donald Elmore (CalTech)
"Molecular Dynamics Simulations of the M. Tuberculosis Mechanosensitive Channel of Large Conductance" |
| 10:40-10:50 AM | Discussion |
| 10:50-11:05 AM | Coffee Break |
Session 4':
Tuesday AM, January 30 | Ligand Recognition and Gating in Ligand-Gated Ion Channels |
|
| Discussion Leader: Henry Lester |
| 10:40-10:55 AM | Henry Lester(CalTech) |
| 10:55-11:20 AM | Titia K. Sixma (Netherlands Cancer Institute)
"The Crystal Structure of AChBP, a Mimic of the Ligand Binding Domain of the Nicotinic Acetylcholine Receptor" |
| 11:20-11:30 AM | Discussion |
| 11:30-11:55 AM | Anthony Auerbach(SUNY Buffalo)
"Acetylcholine Receptor Gating: Mapping the Conformational Wave" |
| 11:55-12:05 PM | Discussion |
| 12:30-1:30 PM | Lunch |
| 1:30-4:00 PM | Free |
| 4:30-6:00 PM | Poster Session |
| 6:00-7:00 PM | Dinner |
| 7:30-9:30 PM | Session 5 |
| |
Session 5:
Tuesday PM, January 30 | Transport Mechanisms |
|
| Discussion Leader: Ron Kaback |
| 7:30-7:45 PM | Ron Kaback (University of California, Los Angeles) |
| 7:45-8:00 PM | Ulrik Gether (University of Copenhagen)
"Endogenous and engineered Zn2+ switches in the cocaine-sensitive dopamine transporter" |
| 8:00-8:10 PM | Discussion |
| 8:10-8:35 PM | Susan Amara (Vollum Institute)
"Excitatory Amino Acid Transporters: Ion Channel and Carrier Functions" |
| 8:35-8:45 PM | Discussion |
| 8:45-9:10 PM | Vassilis Koronakis (University of Cambridge)
"Bacterial Protein Export and Drug Efflux via the TolC Channel-Tunnel" |
| 9:10-9:20 PM | Discussion |
| 9:20-9:35 PM | Ian Collinson (Harvard Medical School)
"Projection Structure and Oligomeric Properties of a Bacterial Core Protein Translocase" |
| 9:35-9:45 PM | Discussion |
Session 6:
Wednesday AM, January 31 | G Protein-Coupled Receptor Dimerization |
|
| Discussion Leader: Kathryn Sandberg |
| 9:00-9:15 AM | Kathryn Sandberg(Georgetown University) |
| 9:15-9:40 AM | Stephane Angers(University of Montreal)
"Oligomeric Assembly of G Protein-Coupled Receptor Complexes Assessed by Bioluminescence Resonance Energy Transfer (BRET)" |
| 9:40-9:50 AM | Discussion |
| 9:50-10:15 AM | Fang Liu (University of Toronto)
"Direct Protein-Protein Interactions Enables Cross-Talk Between Dopamine D1-like Receptors and Ligand Gated Ion Channels"
|
| 10:15-10:25 AM | Discussion |
| 10:25-10:50 AM | Mario Mellado (Autonomous University of Madrid)
"Chemokine Receptor Activation by Homo- and Heterodimerization" |
| 10:50-11:00 AM | Discussion |
| 11:00-11:15 AM |
Coffee Break |
| 10:25-10:50 AM | Michael Stowell (MRC, Cambridge)
"Imaging the Acetylcholine Receptor in the Desensitized State: Structural Evidence for a Two Gate Mechanism" |
| 11:30-11:40 AM | Discussion |
| 10:25-10:50 AM | Jeremy Lakey (University of Newcastle)
"Direct Assembly of Ion Channels onto Metal Electrodes" |
| 11:55-12:05 AM | Discussion |
| 12:05-12:30 AM | Business Meeting |
| 12:30-1:30 PM | Lunch |
| 1:30-4:00 PM | Free |
| 4:30-6:00 PM | Poster Session |
| 6:00-7:00 PM | Dinner |
| 7:30-9:30 PM | Session 7 |
Session 7:
Wednesday PM, January 31 | Ion Channel Structure and Gating |
|
| Discussion Leader: Diane Papazian |
| 7:30-7:45 PM | Diane Papazian |
| 7:45-8:10 PM | Eduardo Perozo (University of Virginia)
"Molecular Rearrangements Underlying Ion Channel Gating" |
| 8:10-8:20 PM | Discussion |
| 8:20-8:35 PM | Jannette Carey (Princeton University)
"Ligand Activation in Cyclic Nucleotide-Gated Channels" |
| 8:35-8:45 PM | Discussion |
| 8:45-9:10 PM | Olga Sokolov (Brandeis University)
"Physical Location of Membrane Domains in Shaker Potassium Channel" |
| 9:10-9:20 PM | Discussion |
| 9:20-9:45 PM | Jacqueline Gulbis(Biomolecular Research Institute, Melbourne, Australia)
"The
Cytoplasmic Assembly of Voltage-Gated Potassium Channels" |
| 9:45-9:55 PM | Discussion |
Session 8:
Thursday AM, February 1 | Assembly and Insertion of Membrane Proteins |
|
| Discussion Leader: James Bowie |
| 9:00-9:15 AM | James Bowie(University of California, Los Angeles) |
| 9:15-9:40 AM | Mark Krebs(University of Wisconsin)
"Biogenesis of an Archaeal Rhodopsin" |
| 9:40-9:50 AM | Discussion |
| 9:50-10:15 AM | Paula Booth(University of Bristol, UK)
"Can We Identify the Forces that Drive the Folding of Integral Membrane Proteins?" |
| 10:15-10:25 AM | Discussion |
| 10:25-10:45 AM | Coffee Break |
| 10:45-11:10 AM | Charles M. Deber(University of Toronto)
"Hydrophobicity, Helicity, and Insertion of Transmembrane Segments" |
| 11:10-11:20 AM | Discussion |
| 11:20-11:45 AM | David Cafiso (University of Virginia)
"Membrane Protein Interactions: Electrostatic Switches and Calcium-Dependent Protein Binding Studied Using Site-Directed Spin Labeling" |
| 11:45-11:55 AM | Discussion |
| 11:55-12:10 AM | Gerd Kochendoerfer (Gryphon Sciences)
"Total Synthesis of Ion Channel Proteins by Native Chemical Ligation" |
| 12:10-12:20 AM | Discussion |
| 12:30-1:30 PM | Lunch |
| 1:30-4:00 PM | Free |
| 4:30-6:00 PM | Poster Session |
| 6:00-7:00 PM | Dinner |
| 7:30-9:30 PM | Session 9 |
Session 9:
Thursday PM, February 1 | Keynote Speakers |
|
| 7:30-8:15 PM | Donald Engelman (Yale University)
"Helix Interactions in Membranes" |
| 8:15-8:30 PM | Discussion |
| 8:30-9:15 PM | Roderick MacKinnon (Rockefeller University)
"Title to be announced" |
| 9:15-9:30 PM | Discussion |
|
| 7:30-8:30 AM | Breakfast |
| 9:00 AM | Bus departs |
