Session 1 Sunday July 30; 7:30-10:00 PM | Regulation of HDL metabolism |
Chair: Daniel Rader
- Dan Rader - University of Pennsylvania: Role of endothelial lipase in HDL metabolism
- Gary Lewis - University of Toronto: Mechanisms of HDL-C lowering in hypertriglyceridemia
- Xian-cheng Jiang - Columbia University: Role of PLTP in HDL metabolism
- Mary Sorci-Thomas - Wake Forest School of Medicine: Effects of apoA-I mutations on HDL metabolism
Meeting Photo-Session Monday August 1; 8:45 AM
Session 2 Monday August 1; 9:00-12:30 noon | Apolipoprotein Structure and Function |
Chair: Michael Phillips
- Michael Phillips - Children's Hospital of Philadelphia: Functional domains of exchangeable apolipoproteins
- Robert Ryan - University of Alberta: Lipid binding-induced helix repositioning in exhangeable apolipoproteins
- Karl Weisgraber - UC San Francisco: Apo E; new insights from structure
- Sissel Lund-Katz - Children's Hospital of Philadelphia: Effects of lipid interaction on the LDL receptor-binding domain of apoE
- Steve Blacklow - Harvard University: Structure-function relationships in the LDL receptor
- Ana Jonas - University of Illinois: What we have learned about the structure of apoA-I from point mutations and spectroscopy.
- Sean Davidson - University of Cincinatti: The orientation of apoA-I helices in reconstituted HDL
Session 3 Monday August 1; 7:30-10:00 PM | Regulation of Lipoprotein Metabolism |
Chair: Harshini deSilva
- Lars Berglund - Columbia University: Regulation of lipoprotein (a) metabolism
- Laura Woollett - University of Cincinatti: The impact of maternal cholesterol on fetal development
- Harshini deSilva - UNC at Charlotte North Carolina: Regulation of lipid transport in the developing fetus
Session 4 Tuesday August 2; 9:00-12:30 noon | Genetics of Dyslipidemia |
Chair: Philippa Talmud
- Ben Bowen - Novartis: The discovery of cardiovascular disease genes in Utah pedigrees
- Tim Aitman - Hammersmith Hospital, Imperial College, London: Genetics of the metabolic syndrome
- Steve Sturley - Columbia University College of Physicians and Surgeons, New York: Dislipidemia genes in yeast and humans
- Gerd Schmitz - University of Regensburg: ABCA1, an ATP luxury gene at the interlink of gucose, fatty acid, and HDL cholesterol metabolism
Session 5 Tuesday August 2; 7:30-10:00 PM | Transcription regulation of lipid metabolism: |
Chair: Tim Osborne
- Tim Osborne - UC Irvine : Differential Regulation of Gene Expression by the Cholesterol Sensing SREBPs.
- Jay Horton - UT Southwestern: SREBP expression in diabetes and lipodystrophy
- Christopher Glass - UC San Diego: Nuclear receptors and macrophage activation
Session 6 Wednesday August 3; 9:00-12:30 noon | Assembly and Secretion of apolipoprotein B-lipoproteins |
Chair: Edward Fisher
- Ed Fisher - Mount Sinai School of Medicine: Molecular Regulation of apoB metabolism in cell free systems
- Janet Sparks - University of Rochester: Targeted PI 3-kinase activation and apoB metabolism in rat hepatoctyes
- Joseph Dixon - Dalton Cardiovascular Research Center: Studies of intracellular apoB transport using 3-D immunocytochemistry and apoB-GFP chimeric proteins.
- Mahmood Hussain - SUNY Health Science Center: Assembly of apoB48-containing lipoproteins in intestinal cells.
Session 7 Wednesday August 3; 7:30-10:00 PM | Intracellular lipid metabolism |
Chair: Robert Farese
- Robert Farese - UC San Francisco: Neutral lipid synthesis: Functional analyses of ACAT and DGAT genes
- David Mangelsdorf - UT Southwestern: Intracellular lipid mediators of gene expression
- Edward Rubin - OCTN2: a gene involved in hepatic triglyceride production identified by gene discovery technology
Session 8 Thursday August 4; 9:30-12:30 noon | Fatty acid transport and utilization in insulin resistance and atherosclerosis |
Chair: Nada Abumrad
- Nada Abumrad - State University of New York Stony Brook: CD36-null and CD36 overexpressing mice: linking glucose and fatty acid metabolism
- Gokhan Hotamisligil - Harvard University: Biological functions of adipocyte/macrophage fatty acid binding proteins
- Gerald Shulman - Yale University: Fatty acids and insulin resistance: mice with liver and muscle LPL overexpression
- Katherine Cianflone - McGill University: Acylation Stimulating Protein
- Jean Schaeffer - Washington University: A novel mouse model of lipotoxic cardiomyopathy
- Maria Febbraio - Cornell University: Cardiomyopathy in the CD36 null mouse
Session 9 Thursday August 4: | After dinner lecture |
- Daniel Steinberg - UC San Diego: Many roads, but not all, lead to atheroma.
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