Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Genetics of Lipids and Cardiovascular Disease
7:40 pm - 8:40 pm
"Genetics of Lipoprotein Metabolism and Coronary Artery Disease"
8:40 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipoproteins and Apolipoproteins
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Lipoprotein Catabolism and Atherosclerosis in the Absence of Lipoprotein Lipase"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cholesterol Trafficking in the Endolysosomal System by NPC Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Lp(a), Plasminogen, and Cellular Sterol Regulation: Tip of the Iceberg"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Plasminogen is an Alternative Lipoprotein with Diverse Cargo and Fibrin-independent Functions in Atherosclerosis-associated Inflammation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"ANGPTL3 Regulates Hepatic Lipoprotein Production: A New Model For Lipid Lowering?"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Approaches to Modulate Plasma Lipids and Lipoproteins
7:30 pm - 7:50 pm
"Developing Gene Therapies for Dyslipidemia: What We've Learned From the Experience With HoFA"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"siRNA Therapy for Lipid Modification"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Monoclonal Antibodies for the Treatment of Dyslipidemia"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Human Genetics to Validate Therapeutic Lipoprotein Targets"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Noncoding RNAs in Lipoprotein Metabolism and Modulation of Cardiovascular Diseases
9:00 am - 9:20 am
"RNA Dynamics in Metabolic Control"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Multitudinous Roles of Non-Coding RNAs in Lipoprotein Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Role of miR-541-3p in the Regulation of LDL, HDL, and Atherosclerosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"MLKL (Mixed Lineage Kinase Domain-Like Protein): An Immunometabolic Nexus of Cardiovascular Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"High Density Lipoprotein Reduces Blood Pressure and Protects Spontaneously Hypertensive Rats Against Myocardial Ischemia-Reperfusion Injury in an SR-BI Dependent Manner"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Identifying the Molecular Mechanisms Linking Changes of Glycosylation with Atherosclerosis Protection in B4galt1 Mouse Model"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Elucidating the Variant-to-function Relationship for LIPA, a Risk Locus of Coronary Artery Diseases"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Short Hydrocarbon-Stapled ApoE Mimetic Peptides Enhance Lipoprotein Uptake"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Metabolism in Adipose Tissue
7:30 pm - 7:50 pm
"Mechanisms and Physiology of Lipid Droplet Formation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mechanisms Promoting the "Safe" Storage of Triglycerides in Adipocytes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Role of MTP in Adipocyte Lipid Hydrolysis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Role and Regulation of ANGPTL4 in Human Adipose Tissue"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Post-Genomic Era in Lipoprotein Metabolism
9:00 am - 9:20 am
"Functional Validation of the 19q13 Plasma Lipid GWAS Locus Implicates the Transcription Factor C/EBPa"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Empowering Mammalian Haploid Genetics to Identify Novel Genes and Pathways in Lipid Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"LDLR and GOLIATH: Regulation of Lipoprotein Metabolism"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Machine Learning Enables New Insights into Genetic Contributions to Liver Fat Accumulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Using Contextual Co-Expression Analysis to Increase Insight in the Biogenesis of ApoB-Containing Lipoproteins"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Genome-Wide Association Studies Linking Plasma and Hepatic Lipids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Permanent Modification of Lipid Levels
7:30 pm - 7:50 pm
"Genome Editing and Epigenome Editing of Lipid Genes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"ApoB-Specific CD4 T Cells in Mouse and Human Atherosclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Is it Ever Wise to Edit Wild-Type Alleles? Engineered CRISPR Alleles Versus 2 Million Years of Human Evolution"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Patient Perspective: The Case for Transformational One-Time Therapies"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Lipoprotein Secretion: From Physics to Physiology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Intracellular VLDL Trafficking and Secretion"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Novel Factors Regulating VLDL Triglyceride Production"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Gain-of-Function Mutations in Microsomal Triglyceride Transfer Protein"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Size is Not Everything: Characterizing Lipoprotein Lifetime in Zebrafish Using a Photoconvertible ApoB Fusion Protein”"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Altered Lipoprotein Metabolism with Accumulation in Lipoprotein Z Predicts Outcome in Alcoholic Hepatitis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cutting-Edge Technologies for Lipid and Lipoprotein Research
7:30 pm - 7:50 pm
"Single-Cell Strategies to Investigate Lipid Metabolism in Heterogeneous Tissues"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Single-Cell Perspectives on Atherosclerosis and Cardiovascular Risk"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"CRISPR-Cas Screen for New Genes Related to LDL Cellular Uptake"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Single-Cell Transcriptomic Signature of Monocytes in African American Subjects with High Plasma Lipoprotein(a)"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Classification of Variants of Uncertain Significance in the ABCA1 Gene using a Fluorescence Based Cholesterol Efflux Assay"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure