Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Links Between Atherosclerosis, Diabetes and Lipoprotein Metabolism
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Cardiovascular Complications of Type 1 Diabetes: Explained by Dysfunctional Lipoprotein Metabolism After All?"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Spatial Control of Bile Acid Metabolism"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sex Differences in Liver Lipoprotein Metabolism and Atherosclerosis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipid Signaling and Intra-Organelle Lipid Metabolism and Transport
9:00 am - 9:20 am
"Unveiling the molecular diversity of human brain lipoproteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms of ER Lipid Quality Control and Lipoprotein Secretion"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of Energy Expenditure by Plasma Ceramide Signaling"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Regulation of Lipogenesis, Lipid Storage and Lipoprotein Secretion by Endoplasmic Reticulum-Localized Lipases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Lipoprotein(a) Size and Level Reduction with Potent Lipid Lowering: An Analysis of the CHORD Trial"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"STARD4-Mediated Cholesterol Transport: A Key Factor in Aggregated LDL-Induced Foam Cell Formation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Post-Transcriptional Regulation of FGF21 in Obesity and Metabolism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The reciprocal regulation between coagulation factor VIII and LDL"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Mechanisms for Lipoprotein Metabolism
7:30 pm - 7:50 pm
"Might Not Be So Bad: The Role of ApoB-Lipoproteins in Hemostasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Insulin Regulation of Lipoprotein Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Smooth Muscle Cell Cholesterol Efflux Pathways Control Vascular Function"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"HDL Regulate Inflammation by an ApoA-I and ABCA1-Dependent Mechanism for Oxylipin Efflux"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Therapeutic Approaches to Target Lipoprotein Metabolism
9:00 am - 9:20 am
"Discovery of Potent Small Molecule Disrupters of Lipoprotein(a) Formation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"CETP Inhibition and Obicetrapib"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Disrupting the Care of Cardiovascular Disease With Single-Course Gene Editing Medicines"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Tuning Inflammation Through Regulation of Peptide Hormone Cleavage"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Lowering TRLs Prevents Diabetes-Induced Changes in Lesional Macrophages and Diabetes-Accelerated Atherosclerosis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Disruption of Chylomicron Secretion Impacts Intestinal Metabolism in Male and Female Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Understanding the Complex Role of Elevated Lipoprotein(a) in Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"ApoE Registry Impacts the Binding of ApoE to its Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical and Biological Insights Into Lp(a) Biology
7:30 pm - 7:50 pm
"Unveiling the Role of Lipoprotein(a) in Atherosclerosis: Evidence of Its Pro-Inflammatory Impact on Monocytes and Endothelium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Function-Informed Structural Studies of Apolipoprotein(a)"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"New Insights into the Role of Lp(a) in Cardiovascular and Valvular Diseases"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Lp(a) Puzzle: Non-Genetic Pieces"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipoproteins in Organ Systems
9:00 am - 9:20 am
"Chylomicron Metabolism by Regulatory T Cells and its Impact on Inflammatory Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Role of LIPC in the Uptake and Transport of Macular Carotenoids"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of Systemic Metabolic Homeostasis by Intestinal Desaturases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Interrogating HDL Biology Through Studies of Its Trafficking Through and Between Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Apolipoprotein B-100 Autoimmunity and Dyslipidemia in Chronic Lyme Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"FITM2 Deficiency Results in ER Lipid Accumulation, ER Stress, Reduced Apolipoprotein B Lipidation, and VLDL Triglyceride Secretion in Vitro and in Mouse Liver and Promotes Atherosclerosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Resolving the Effects of Lipoprotein(a) on Thrombosis and Fibrinolysis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Discordance in Estrogenic Effects on Lipid Metabolism in Trans Females vs Cis Females"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Systems and Technologies for Lipoprotein Research
7:30 pm - 7:50 pm
"State-of-the-Art Systems and Technologies for Lipoprotein Research"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Somatic Genome Editing for the Study and Treatment of Lipid Disorders"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"New Structural Insights Into Lipase Regulation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Versatility of Reconstituted High Density Lipoproteins"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanisms of Lipoprotein Transport and Uptake
9:00 am - 9:20 am
"The ABCs of Lipid Transport"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"ANGPTL3 Deficiency Associated Adaptations in Hepatic Lipoprotein Production and Clearance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mechanisms of Foamy Monocyte Formation in Atherosclerosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identification of Novel Regulators of LDL Transcytosis Using Proteomics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Sex Differences in Bile Acid Metabolism Impact Cholesterol Homeostasis and Cardiovascular Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hypertriglyceridemia Promotes Aortic Aneurysm Formation and Rupture in Angiotensin II Infused Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"FFAR4: An Emerging Target to Reduce Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Diabetic Dyslipidemia Augments CD36-Mediated Lipid-Loading in Circulating Ly6Clo Monocytes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Approaches for Interrogating Lipoprotein Biology
7:30 pm - 7:40 pm
"Defining the Glycoproteomic Landscape of Lipoprotein(a) for Potential Biomarkers in CVD"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
"Insights From Whole Genome Sequencing and Plasma Lipids"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Effects of ApoA-I [human] Post AMI - Mechanistic Perspectives"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Updates in Lipoprotein Research: Everything Old is New Again"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure