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Lung Development, Injury and Repair

Gordon Research Conference

Post-COVID Return to Respiratory Health

August 13 - 18, 2023

Chairs

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Vice Chairs

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Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Lung Development, Injury and Repair GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Proper lung function is paramount to human health, a fact underscored by the COVID pandemic. Aside from respiratory viral infection, there are many other causes for lung diseases, including genetic predisposition, pollutant, allergen, bacterial infection and prematurity. It is well established that the adult lung re-activates developmental programs to repair the lung in response to injury. However, in pathological conditions, dysplastic remodeling sets the foundation for chronic lung diseases. Research is being conducted to comprehensively define the molecular progression of lung development on multiple scales, to draw parallels between lung development and regeneration, and to uncover distinctions between normal repair and dysplastic remodeling. It is exciting time in the study of lung biology. The latest discoveries in the field of Lung Development, Injury and Repair will be presented, debated, and translated into more effective clinical practice at the 2023 Gordon Research Conference.

Related Meeting

This GRC will be held in conjunction with the "Lung Development, Injury and Repair" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Post-COVID Opportunities to Broaden Lung Biology Discussion Leaders: and
7:40 pm - 8:00 pm	"Progress and Opportunities in Lung Development, Injury and Repair: A NHLBI Perspective"
8:00 pm - 8:15 pm	Discussion
8:15 pm - 8:55 pm	"Breaking Down Barriers to Lung Repair and Regeneration: Unlocking the Plasticity of Alveolar Epithelial Cells"
8:55 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Post-COVID Priorities in Lung Injury Repair Discussion Leaders: and
9:00 am - 9:20 am	"Lung Stem Cells in Injury Repair"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	"Human iPSCs to Study the Molecular Programs of Lung Injury and Repair"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Mechanistic Themes from the Marfan Lung"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Group Photo / Coffee Break
10:50 am - 11:10 am	"Signaling Factors Promoting Pathological Fibroblast Differentiation in Injury Models"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"BDNF Regulation of Airway Mucins"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Non-Resolvable COVID-19: A Tale of Transitional Stem Cell Recruitment and Extracellular Matrix Deposition"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Emphysema or Fibrosis: Two Sides of the Same Coin"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tipping the Balance from Dysplastic to Regenerative Repair Discussion Leaders: and
7:30 pm - 7:50 pm	"Fungal Dysbiosis in Post-Influenza MRSA Infection"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"Role of IL-10 in transcriptomic alterations in the developing mouse lung caused by in utero electronic-cigarette aerosol exposures"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	"Function of Genetic Determinants for COPD and IPF in Lung Epithelial Cells"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	"Role of Diet and Gut Microbiome in Regulating Lung Injury Responses"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Epithelial Determinants of Functional Alveolar Repair"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	An Ageless Lung Discussion Leaders: and
9:00 am - 9:20 am	"Transcriptional Control and Evolution of Lung Alveolar Cell Fates"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	"Context-Dependent Requirements for Mitochondria Function in Lung"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Age of the Fibroblast: Transition or Existing on a Spectrum?"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"A 4-Dimensional Fabric: Considerations of Space and Time in Lung Development and Disease"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Defining the Pulmonary Developmental Niche: Identifying Placental Mechanisms of Developmental Lung Injury"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Proteomic Analysis of Human Bronchopulmonary Dysplasia Lung"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Submucosal Gland and Rare Cell Progenitors in the Ferret Proximal Airway"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Insights from Single Cell Resolution Discussion Leaders: and
7:30 pm - 7:50 pm	"COVID-19: Insights from In Vitro Infection and a Human SARS-CoV-2 Challenge Study"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"Endothelial S1PR1 Suppresses Endothelin 1 Signaling and Attenuates Fibrosis After Influenza Virus Infection"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	"Effect of Environmental Lighting on Circadian Gating on Lung Injury from Influenza"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	"Genetic and Epigenetic Regulators of Alveolar Progenitor Function in Regeneration"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Alveolar Responses to Recurrent Injury"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Fibroblasts Discussion Leaders: and
9:00 am - 9:20 am	"Fibroblast Roles in Fibrosis and Repair"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	"Directed Differentiation of Pluripotent Stem Cells into Functional Lung-Specific Mesenchyme"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Fibroblast Tuning of the Inflammatory Niche"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"The Mesenchymal Niche During Airway Epithelial Regeneration"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Wnt Signaling in Mesenchymal Vascular Progenitor (MVPC) Drives Adaptive Angiogenesis During Fibrosis and Regulates Pulmonary Tissue Repair"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Biomarkers of Pulmonary Fibrosis – Their Utility in Drug Discovery"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Unusual Interstitial Pneumonia: How Should We Think About Fibrosis in Children?"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Lung as a Sensory Organ Discussion Leaders: and
7:30 pm - 7:50 pm	"Linking Tuft Cells to Airway Damage Sensing and Repair"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"Cellular and Molecular Diversity of Peripheral Glia in the Lung and their Development"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	"Sensory Mechanisms of the Mammalian Airways"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	"Infection Induced Inflammatory Signal Triggers Lung Dysplastic Remodeling"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Multiple Modes of Lung Repair in Severe Viral Pneumonia"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Circulating Cells in the Lung-Body Dialogue Discussion Leaders: and
9:00 am - 9:20 am	"Molecular Pathology in Patients with SARS-CoV-2 Pneumonia Reveals Disease Pathobiology"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	"TREM2 Regulates the Lung Innate Immune Response and the Severity of Hyperoxia Induced Lung Injury"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Macrophage Heterogeneity During Repair of Acute Lung Injury"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Early Life Pulmonary Viral Infection Alters Long Term Function and Structure"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Tissue-Resident Macrophage Regulation of Airway Submucosal Gland Development"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Fatty Acid Binding Protein 5 (FABP5) Promotes the Resolution of Inflammation in a Mouse Model of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Profiling and Mapping of Hematopoietic Stem Cell Reservoirs in the Human Lung"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: The Rules and Exceptions of Pulmonary Vessels Discussion Leaders: and
7:30 pm - 7:50 pm	"Pulmonary Vascular Remodeling a Breakdown in Communication?"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"SIN3A Directs Lung and Pulmonary Vascular Development by Controlling the Balance of Histone Acetylation"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	"Beyond Water: A Surprising Role for Aquaporin 1 in Regulating Lung Vascular Cell Function"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Rearranging the Genome for the First Breath at Birth"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Cedars-Sinai Medical Center

Kalpaj and Mona Parekh

John Engelhardt

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL168969. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

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Conference History Lung Development, Injury and Repair (GRS)

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