Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: New Model Systems to Study Lung Development, Aging and Regeneration
7:40 pm - 8:10 pm
"Cell-Cell Interactions Regulating Lung Progenitor Cells"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Crystal Ribcage: A Platform for Probing Real-Time Lung Function at Cellular Resolution"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Lung Morphogenesis Across the Tree of Life"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vasculature in the Pathobiology and Repair of Chronic Lung Disease
9:00 am - 9:25 am
"Novel Models for Blood Vessel Repair and Angiogenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Adult Progenitors in Vascular Intimal Remodeling"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Redox Signaling in the Pulmonary Vasculature"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mechanisms of Lung Vascular Repair, Aging, and Fibrosis"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Cell-Cell Communication as a Pathomechanism of Pulmonary Vascular Remodeling"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Biology-Based Maps of Cell States and Fates in Aging or Diseased Lungs
6:00 pm - 6:20 pm
"Systems Biology Insights into Lung Development and Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Systems Biology-Based Maps of Aging and Injured Lungs"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Short Talk Selected from Poster Abstracts
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Glutathione-Dependent Protein Oxidation Controls Alveolar Type 2 Epithelial Cell Plasticity"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Human iPSC Cell-Derived Models of Cell States and Fates in Interstitial Lung Diseases"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Architects: Redesigning the Fibrogenic Blueprint of Aberrant Lung Repair
9:00 am - 9:25 am
"Therapeutic Strategies to Reverse Lung Mesenchymal Fibrogenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cellular Interactions in Idiopathic Pulmonary Fibrosis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"The Role of Pleural Mesothelial Cells and Lung Fibroblasts in Progression from Lung Injury to Fibrosis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Alveolar Epithelial Dysfunction as a Targetable Driver of Pulmonary Fibrosis"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mechanisms of Effective Lung Repair after Injury"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin and Epigenetic Regulation of Lung Development and Disease
6:00 pm - 6:20 pm
"Genetics and Epigenetics of COPD Risk"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Single Cell Epigenomics to Study Dysregulation of Chromatin State Across Lung Cancer Evolution"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Short Talk Selected from Poster Abstracts
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Epigenetic Mechanism of Vascular Remodeling and Targeted Therapies in Cardiopulmonary Diseases"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Integration of Informatics to Understand Disease Pathogenesis & Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Loss of the Alveolar-Capillary Unit in Development and Aging
9:00 am - 9:25 am
"Mechanisms of Airway Differentiation in Human Lung Development"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Role of the Alveolar Niche in Lung Longevity"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Vascular Cross-Talk in Lung Homeostasis, Aging, and Regeneration"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"More Than Just a Wrap: The Multiple Talents of the Mesothelium"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Adult Consequences of Perinatal Lung Injury: Evidence from Preclinical Studies"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Spanning Inflammation and Restoration: Immune Influences on Lung Regeneration
6:00 pm - 6:25 pm
"Promoting Lung Recovery: Epigenetic and Metabolic Control of Regulatory T Cell Function"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Thrombin Receptor Signaling in the Lung Lymphatic Vasculature: Novel Roles for an Old Vascular Pathway"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Short Talk Selected from Poster Abstracts
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Immune Mechanisms Drive the Transitional Cell State in Aberrant Lung Repair"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Role of Immune Subpopulations in Lung Homeostasis and Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanisms of Chronic Lung Disease in the Aging Lung
9:00 am - 9:25 am
"Immune and Structural Cell Crosstalk in Regulation of Lung Fibrosis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mitochondria Dysfunction and Senescence at the Spotlight of Lung Aging and Fibrosis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Cell-Cell Interactions in Lung Aging"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Lung Entropy: A Thermodynamics-Inspired View of Lung Aging to Guide Therapeutic Development"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Alveolar Type 2 Cell Rejuvenation as a Window into Reversing Pulmonary Fibrosis and Promoting Lung Healthspan"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Linking the Rare to Repair: Identifying the Targetable Genes and Pathways that Drive Uncommon Lung Diseases
6:00 pm - 6:20 pm
"Identification of Disease Mechanisms in Alpha-1 Antitrypsin Deficiency-Associated Emphysema"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Epithelial Progenitors Predict Lung Cancer Regression"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Gene and Cell Therapies for Childhood Interstitial Lung Diseases and Bronchopulmonary Dysplasia"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Cell Based Mechanisms of Rare Lung Diseases"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"TBX4 Underlying Pulmonary Vascular Dysfunction"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure