Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Building the Lymphatic Vasculature
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Lymphatic Vessels in Organ Growth and Regeneration"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Using Enhancer Analysis to Delineate the Transcriptional Regulation of Early Lymphatic Development"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Developmental Origins of Lymphatic Endothelial Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Deciphering the Biophysical Rules that Govern Chromatin Navigation of the SOX18 Transcription Factor"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Lymphatics at the Barriers
9:00 am - 9:20 am
"Growth Factors in Lymphatic Development, Disease and Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Role of Meningeal Lymphatics in Immune Surveillance of the Brain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"In Vivo Imaging of Cerebrospinal Fluid Flow and Clearance Through Lymphatic Vessels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Pathogenic Mechanisms of Vascular Malformations"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Angiopoietin/Tie Signalling in Lymphangiogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Pulmonary Lymphatics: A Role in Lung Injury?"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Angiopoietin-Tie Signaling in Postnatal Lymphatic Vessel Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism of Lymphatic Endothelial Cells
7:30 pm - 7:50 pm
"Lymphangiogenic Signaling Pathway Regulates Adipose and Hepatic Responses in Obesity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Macrophage and Regulation of Lymphatic Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Lymphatic Vasculature in Organ Growth"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Lymphatic Pathophysiology in Congenital Heart Disease with Increased Pulmonary Blood Flow"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Control of Lymphatic Expansion by FOXO Transcription Factors"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Mechanics of Lymphatics
9:00 am - 9:20 am
"Regulation of Lymphatic Vessel Integrity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms by Which Pressure Regulates Lymphatic Pumping"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Novel Associations Between Lymphedema and Cardiovascular Disorders"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lymphatic Junction Molecules as Signaling Regulators"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"BMP-SMADs Promote Lymphatic Vessel Stabilization by Tuning WNT Signaling"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Impact of the Space Environment on Lymphatic Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Lymphatics and Statins: A Lova-Hate Story"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetics and Pathophysiology of Rare Lymphatic Diseases
7:30 pm - 7:50 pm
"Dealing with Variants of Unknown Significance (VUS): Functional Characterization of Variants in Primary Lymphoedema Patients"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Heterogeneous Pathophysiological Basis of Primary Lymphedema"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sodium Imaging: Lessons Learned from Lipedema and Lymphedema"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Underlying Histological Characteristics of Lymphedema and Lipedema"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Lymphangiogenic Signaling in Diseases of the Cardio-Renal Axis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Cell Navigation to and from Lymphatics
9:00 am - 9:20 am
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Leukocyte Migration and Immune Regulation Within Afferent Lymphatics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Integrin avβ3 Signaling Regulates Developmental Lymphangiogenesis in Mice"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Lymphatic Endothelial Cell Identity Is Controlled by a GATA2 Bound Enhancer"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Transport of Cellular and Molecular Cargo via Intestinal Lymphatics and Its Association with Inflammatory Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Role of the Lymphatic System in Cancer Progression"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Roles of Cardiac Lymphatic Vessels in Zebrafish Heart Development and Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Primordial Lymph Vessel Formation in the Mouse"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lymphangiogenesis in Overdrive: Inflammation and Cancer
7:30 pm - 7:40 pm
"Studying the Mechanisms that Prepare the Developing Lung for Inflation at Birth"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"A Novel Biogenic Amine Released by Lymphatic Endothelial Cells Restrains Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"A Precision Medicine Approach to Understanding Congenital Lymphatic Anomalies"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"The Natural Product Iripallidal Promotes Lymphangiogenesis in Response to Injury via RASGRP3"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"RASA1-Mediated Control of Lymphatic and Blood Vascular Development and Function"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Novel Treatment Target in Obesity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"MHC Class II Expression by Tumoral Lymphatics Is Required for Tumor Specific Signature and Suppressive Functions of Treg Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Lymphatic Vessel Heterogeneity in the Era of Single Cell Analysis
9:00 am - 9:20 am
"Reprogramming of the Liver Lymphatic Endothelium During Chronic Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Zebrafish Lymphatic Endothelial Cell Specification at Single Cell Resolution"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Single-Cell Transcriptional Cross-Mapping of the Mouse and Human Lymph Node Lymphatic Vasculature"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Novel Insights into Lymphatic Development from the Zebrafish"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Foxc Transcription Factors in Organ-Specific Lymphatic Function"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Piezo1-Mediated Activation of Lymphatic Function and Growth"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Identifying Novel Modifier Genes Related to Naturally-Occurring Heterogeneity of Lymphatics Within a Diverse Genetic Population"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Engineering and Therapeutics for the Lymphatic System
7:30 pm - 7:50 pm
"Targeting the Mesenteric Lymph Using Triglyceride-Mimetic Prodrugs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lymphatic Tissue Engineering"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cell Fate Mechanisms that Drive Lymphangiogenesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Engineering Biomaterials for Lymphatic Morphogenesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Theralymph: An Innovative H2020 Program to Perform Gene Therapy for Lymphedema"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure