Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Emerging Discoveries in Lymphatic Research
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Mechanisms of Adult Lymphatic Renewal and Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Unexpected Discovery of Prox1+ Vessels in Two Hidden Places"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Gut Lymph Model Based Treatment Strategies to Alleviate Organ Failure in Acute and Critical Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Lymph Node Lymphatics Help Shape the Immune Response"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphatic Vessel Heterogeneity in Health and Disease
9:00 am - 9:20 am
"Lymphangiogenic Growth Factor Mechanisms and Translation to Therapeutics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Notch4 Functions in Organ-Specific Lymphatic Vessel Maintenance"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Novel Genetic Findings on Heterogeneity of Primary Lymphedema"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Manipulation of Dural Lymphatic Vessels in Alzheimer’s Disease-Related Amyloid Pathology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"The Role of CNS-Draining Lymphatics in Neurodegeneration"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Lymphatic Vessels of Peritoneal Organs"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Adipose-Lymphatic Interactions in Obesity and Lymphedema at a Single-Cell Resolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Lymphatic Dysfunction in the Pathogenesis of Emphysema"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatic Vessel Morphogenesis: From Progenitors to Functional Vessels
6:00 pm - 6:20 pm
"Studying the Origins of Lymphatics and Lymphatic-Related Cells using the Zebrafish"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Single Cell Profiling Reveals the Regulation of Venous to Lymphatic Endothelial Cell Differentiation Controlled by Prox1 in the Developing Embryo"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Developmental Origins of Lymphatic Endothelial Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Single Nuclei Multiomic Analyses Identify Novel Human Cardiac Lymphatic Progenitors in the Epicardium"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Blood and Lymphatic Endothelial Cell Plasticity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Lymphatic Drainage: Mechanism, Mechanics, Imaging and Emerging Therapeutic Approaches
9:00 am - 9:20 am
"Targeted Therapies for Enhancing Lymphatic Function in Lymphedema"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Phase II Lymfactin® Study; a Double-blind, Placebo-controlled, Randomized Study to Assess the Efficacy, Safety and Tolerability of Lymfactin® Treatment for Breast Cancer-Related Lymphedema"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Design of a Growth Factor Releasing Implantable Device to Prevent the Onset of Breast Cancer Related Lymphoedema"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"KATP Channels in Lymphatic Function"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Current Status of Lymphatic Flow Disorders: Intersection of Clinical and Basic Science"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Obesity-induced Lymphatic Valve Dysfunction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Characterization of the Mouse Colon Lymphatic Network Architecture and Transit from the Colonic Submucosa"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Key Signalling Networks and Dysregulated in Patients with the Adipose Disorder, Lipoedema"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Decisions on Lymphatic Endothelial Cell Identity, Quiescence and Growth
6:00 pm - 6:20 pm
"Dissecting the Mechanisms by which Lymphatic Endothelial Identity is Transcriptionally Controlled"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"The Phosphodiesterase 2A Regulates Lymphatic Development Through Modulation of a Crosstalk Between cGMP and NOTCH Signaling"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Developmental Programming of Lymphatic Endothelial Progenitors"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Hyperactive KRAS Signaling Impairs Lymphatic Valve Morphogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Metabolic Decisions Controlling Endothelial Quiescence and Growth"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunomodulatory Functions of Lymphatic Vessels
9:00 am - 9:20 am
"Dendritic Cell Interactions with and within Lymphatic Capillaries"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"The Role of Lymph Flow in Innate Immunity in the Lymph Node"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"New Insights into Lymphatic Endothelial Cell Antigen Archiving and the Influence on Immune Memory"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"New Capillary Lymphatic Endothelial Cell Subtype as a Driver of Lymphatic Malformation Pathology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Cross-Talk Between Lymphatics and Immune Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Regulation and Impact of Cardiac Lymphangiogenesis in Pressure-overload-induced Heart Failure"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"The Role of Lymphatics in Inflammation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatic Vessels in Cancer: Therapeutic Opportunities
6:00 pm - 6:20 pm
"Investigating Lymphatic Transport in Anti-tumor Immunity and Metastasis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Quality of CD8+ T Cell Immunity Evoked in Lymph Nodes is Compartmentalized by Route of Antigen Transport and Functional in Tumor Context"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Vascular Changes in Tumor-Draining Lymph Nodes with Implications for Tumor Immunity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"15-Lipoxygenase Drives Inflammation Resolution and Treg Trafficking in Lymphedema"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Melanoma-shed, Lymph-borne CSPG4 Conditions the Pre-Metastatic Lymph Node Niche"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The Consequences of Lymph Node Metastasis on Anti-Tumor Immunity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Signalling Pathways for Lymphatic Vessel Growth and Pathology
9:00 am - 9:20 am
"Lymphatic Endothelial Sprouting and Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"A Specific Requirement for Physical Interaction Between EPHB4 and RASA1 for the Development and Function of Lymphatic Vessel Valves"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Signaling Pathways Regulating Lymphatic Vascular Growth"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Analysis of Genomics England 100,000 Genomes Data Associate the Transcription Factor ERG with Primary Lymphoedema"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Novel Mechanisms of VEGFR3 Regulation During Vascular Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Molecular Dissection of Fluid-Induced Mechanotransduction Pathway in Lymphatic Endothelial Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Cystathionine ß-synthase as Novel Endogenous Regulator of Lymphangiogenesis via Modulating VEGF receptor 2 and 3"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Scaffolding of Lymphatic Endothelial Cell Signaling Nodes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Beyond Lymphangiogenic Pathways
6:00 pm - 6:20 pm
"Lymphatics and Lymphangiocrine Factors in Organ Growth and Repair"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Lymphangiocrine Signals are Required for Proper Intestinal Repair after Cytotoxic Injury"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Physiological and Immunological Role of the Lymph"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Enteral Treatment with a Mitochondrially-targeted Antioxidant Preserves Pulmonary Lymphatic Function in an Ovine Model of Congenital Heart Disease with Increased Pulmonary Blood Flow"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"How Does a Lymphatic Diagnosis Influence Pathologic Interrelationships?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure