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Lymphatics

Gordon Research Conference

Lymphatic Vascular Diversity in Development, Tissue Homeostasis, Disease and Therapeutic Strategies

March 3 - 8, 2024

Chairs

and

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Lymphatics GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2024 Gordon Research Conference on Lymphatics will bring together leading international scientists, clinicians, and trainees across all aspects of lymphatic vessel biology to present and discuss the latest advances in the field. The meeting will feature cutting-edge science in cell biology, development, genetics, physiology, aging, oncology, immunology, metabolism, mechanobiology, neuroscience, systems biology, mathematical modeling, and therapeutics. Advances in our basic understanding of the cellular and molecular regulation of lymphatic vasculature in health and disease have continued apace in recent years and have opened up exciting new therapeutic opportunities in diverse disease settings. The primary goal of this meeting is to serve as a forum to communicate the latest research advances in lymphatic biology and provide the opportunity to build collaborative partnerships between scientists, clinicians, industry, and philanthropy. Ample opportunities for the presentation of research by early career investigators and underrepresented minorities will be provided. Building on the success of previous years, the 2024 Gordon Research Conference on Lymphatics will be preceded by a Gordon Research Seminar on Lymphatics. An informal patient session will take place on Tuesday afternoon and there will be an informal session from the NIH and Lipedema Foundation on Thursday afternoon, attendance is highly encouraged for both of these sessions.

Related Meeting

This GRC will be held in conjunction with the "Lymphatics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Conceptual Advances in Lymphatic Vessel Biology Discussion Leader:
7:40 pm - 8:00 pm	"Principles of Endothelial Resilience in Lymphatic Capillaries"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"The Duality of Peritoneal Lymphatic Drainage"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Meningeal Lymphatics Control Brain Function"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Exploring Novel Lymphatics for CSF Outflow or Brain Clearance"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Paradigms in Lymphatic Development Discussion Leaders: and
9:00 am - 9:20 am	"Formations and Malformations of Lymphatic Vessels"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Gain of Function Pathogenic Variants in RIT1 Cause Central Conducting Lymphatic Anomaly"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Lymphatic Function Regulated by the FLCN Tumor Suppressor"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Adm-Elk3 Signaling Axis Regulates Sex-Dependent Cardiac Lymphatic Vessel Formation"
10:25 am - 10:30 am	Discussion
10:30 am - 10:55 am	Coffee Break
10:55 am - 11:05 am	"Hippo Signaling Regulates Transitory Meox1 Control of Cell Adhesion and Sprouting in Lymphatic Development"
11:05 am - 11:10 am	Discussion
11:10 am - 11:30 am	"Molecular Characterization of the Functional Roles of Lymphatics Secreted Reelin in Cardiac Growth and Repair"
11:30 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Implementing Conditional Genetics in Zebrafish to Study Lymphatic Development"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: , and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Understanding and Targeting Lymphatic Vessels in Disease Discussion Leaders: and
7:30 pm - 7:50 pm	"Resolution of Inflammation in Lymphedema: A Therapeutic Pathway for an Unmet Medical Need"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Skull Progenitor Cell-Driven Meningeal Lymphatic Restoration Improves Neurocognitive Functions in Craniosynostosis"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"The Role of the Cardiac Lymphatics During Neonatal Heart Regeneration"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Ileum-Draining Lymphatic Vessels Require S1PR1 to Maintain Valve Integrity and Prevent Ileitis-Independent Formation of Tertiary Lymphoid Structures"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Mechanosensation and FOXO1: Tied Together in the Lymphatics"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Lymphatic Vessel Drainage, Mechanics, and Function Discussion Leaders: and
9:00 am - 9:20 am	"Manipulating VEGF-C and its Signaling Sidekick"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Identification of BCAR1 as a Novel Candidate Gene for Hydrops Fetalis and Lower Limb Lymphedema"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Lymphatics and Lymphangiogenesis in Kidney Pathophysiology"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"A Three-Dimensional Biomimetic Model of Lymphatics Reveals Cell-Cell Junction Tightening and Lymphedema via a Cytokine-Induced ROCK2/JAM-A Complex"
10:25 am - 10:30 am	Discussion
10:30 am - 10:55 am	Coffee Break
10:55 am - 11:05 am	"Deconvolving Functional Crosstalk Between the Lymphatic Vasculature and Adaptive Immunity"
11:05 am - 11:10 am	Discussion
11:10 am - 11:30 am	"High-Resolution Imaging of Cerebrospinal Fluid Clearance Pathways to Lymphatics"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	"Coupling Cerebral Venous Flow and Glymphatic-Lymphatic Fluid Drainage"
11:45 am - 11:50 am	Discussion
11:50 am - 12:10 pm	"Obesity, Metabolic Syndrome and Lymphatic Dysfunction"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"A Novel Role for Csf1R During Early Postnatal Lymphatic Development in the Lung"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Lymphatic System, Stem Cells, and Metabolism Discussion Leaders: and
7:30 pm - 7:50 pm	"Lymphatic Vascular Niches Expand Stem Cell Potency"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Dual Fluorescent ETV2/PROX1 Reporter to Track the Emergence of Lymphatic Endothelial Cells (LECs) from Human-Induced Pluripotent Stem Cells (hiPSCs)"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Meningeal Lymphatics in Migraine Pathophysiology"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Metabolic Mechanisms Regulating Lymphatic Vascular Development"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Organ-Specific Lymphatic Development"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Lymphatics in Vascular and Cardiovascular Disease Discussion Leaders: and
9:00 am - 9:20 am	"Deep Phenotyping in Primary Lymphatic Anomalies"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Insulin Regulation of Lymphatic Lipid Drainage and Transport in Mice"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Applying the Finishing Touch: Modulating the VEGFC Signaling Pathway"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Sex-Dependent Effects of Panx1 Deletion in Lymphatic Endothelial Cells on Atherosclerotic Disease"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Insights on PI3K Mutations in Lymphatic Malformations"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Deletion of FOXC1 and FOXC2 Causes Abnormal Lymphangiogenesis in the Mitral Valve During the Progression of Myxomatous Degeneration"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Primary Lymphedema: Expanding the Complex Genetic Background and Pathophysiological Pathways"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Improvement of Histopathological Diagnostics of Lymphovascular Diseases Through Spatial Deep-Phenotyping Using Non-Destructive Three-Dimensional Histopathology"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lymphatics in Cancer and Metastasis Discussion Leaders: and
7:30 pm - 7:40 pm	"Lymphatics Provide an Intrinsically Tolerant Route for Metastasizing Cancer Cells"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 8:05 pm	"Extracellular Matrix and Regulation of Anti-Tumor Immunity"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Rictor Induces AKT Signaling to Regulate Lymphatic Valve Formation and Maintenance"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Mechanisms and Consequences of Immune Suppression in Metastatic Lymph Nodes"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Metabolic Reprogramming of Cancer Cells in Lymph Nodes"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Immunomodulatory and Hematopoietic Lymphatic Vessels Discussion Leaders: and
9:00 am - 9:20 am	"The Regulation of Lymphatic CCL21 Gradients"
9:20 am - 9:25 am	Discussion
9:25 am - 9:35 am	"Transport of Lymph, Blood, Antigens and Cytokines in Lymph Nodes"
9:35 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Dynamic Tracking of Interstitial and Lymphatic Outflow Using Endogenous and Exogenous Tracers"
10:00 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Defining the Mechanisms by Which PROX1 Represses Hematopoiesis in the Lymphatic Vasculature"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart"
11:35 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"New Insights Into Immunomodulatory Functions of Lymphatic Endothelial Cells"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:25 pm	"Unlocking the Potential of Ocular Lymphatic Channels"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lymphatic Vessel Diversity and Heterogeneity in Health and Disease Discussion Leader:
7:30 pm - 7:40 pm	"TGF-ß Family Members Dysregulate the Homeostasis of Lymphatic Vessels as Negative Lymphoangiocrine Signals"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 8:05 pm	"Lymphatics and Lymphangiocrine Signaling in Bones"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Button Junction Development is Regulated by VEGFR3 Signaling"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Lymphatic Vessels and Bone"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"Endothelial Mechano-Regulation in Development and Disease"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Regulation of Lymphatics Development and Function by miR-22"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL172574. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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