Conference Description
The Lysosomal Diseases GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.
This meeting is the premier independent international forum for discussion of cutting-edge research on the biology of lysosomes and and its clinical application: the concept is to link function to pathophysiology for innovative therapies. The program will cover the latest discoveries that advance knowledge about basic lysosomal function; thoroughly explore how function is impaired in lysosomal diseases - and how this science can be exploited to inform more universal application in biology and medicine. Whenever possible, advances in science will be linked to deep understanding of the clinical phenotype and authentic therapeutic discovery. The widest participation from molecular cell biologists, geneticists, clinical investigators and biochemists is envisaged. The meeting will also shed light on pathological aspects that extend beyond storage - including the extended role of the lysosome in neurodegeneration, energy metabolism, infection and immunity.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by November 2, 2024. Please check back for updates.
Keynote Session: Lysosomal Function in Health and Disease
Discussion Leaders
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Timothy Cox (University of Cambridge, United Kingdom)
Speakers
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Beverly Davidson (University of Pennsylvania and CHOP, United States)
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James Shayman (University of Michigan, United States)
Lysosomal Protein Function and Disease Mechanisms
Discussion Leaders
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Judith Klumperman (University Medical Center Utrecht, The Netherlands)
Speakers
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Bruno Gasnier (Université Paris Cité, France)
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Xiaochen Wang (Chinese Academy of Sciences, China)
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Bhushan Nagar (McGill University, Canada)
Novel Aspects in Lysosome Biology
Discussion Leaders
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Markus Damme (University of Kiel, Germany)
Speakers
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Rushika Perera (University of California, San Francisco, United States)
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Wim Annaert (VIB&KU Leuven, Belgium)
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Juan Bonifacino (National Institute of Child Health and Human Development, NIH, United States)
Lysosomal Diseases and What We Learn from Preclinical Studies
Discussion Leaders
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Heather Gray-Edwards (Univeristy of Massachusetts Can Medical School, United States)
Speakers
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Steven Gray (University of Texas Southwestern Medical Center, United States)
Lysosomal Processes and Biomarkers Implicated in the Pathogenesis of Rare and Common Disorders
Discussion Leaders
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Nicole Muschol (University Medical Center Hamburg-Eppendorf, Germany)
Speakers
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An Dang Do (Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States)
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Susan Cotman (Mass General/Harvard Medical School, United States)
Therapies for Lysosomal Diseases and Clinical Trials
Discussion Leaders
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Joseph Muenzer (University of North Carolina at Chapel Hill, United States)
Speakers
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Heather Gray-Edwards (Univeristy of Massachusetts Can Medical School, United States)
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Pim Pijnappel (Erasmus MC University Medical Center, The Netherlands)
Lysosomes in Neurodegeneration and Underdiagnosed Lysosomal Diseases
Discussion Leaders
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Rebecca Ahrens-Nicklas (The Children's Hospital of Philadelphia, United States)
Speakers
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Ellen Sidransky (National Human Genome Research Institute, NIH, United States)
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Mark Sands (Washington University School of Medicine in St. Louis, United States)
Gene Editing and Novel Therapies for Lysosomal Storage Diseases
Discussion Leaders
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Jonathan Cooper (Washington University in St. Louis, School of Medicine, United States)
Speakers
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Nicole Muschol (University Medical Center Hamburg-Eppendorf, Germany)
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Richard Proia (NIDDK/NIH, United States)
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Greg Newby (Johns Hopkins University, United States)
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Raymond Wang (Children's Hospital of Orange County, United States)
Late-Breaking Discoveries in Lysosomal Diseases
Discussion Leaders
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Simon Jones (Manchester University NHS FoundationTrust, United Kingdom)
Speakers
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Constantinos Demetriades (Max Planck Institute for Biology of Ageing (MPI-AGE), Germany)
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Ben Deverman (Broad Institute of MIT and Harvard, United States)
The GRC Power Hourâ„¢
Organizers
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Ellen Sidransky (National Human Genome Research Institute, NIH, United States)
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Claudia Parra-Ruiz (Pontificia Universidad Católica de Chile, Chile)