Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Leading Edge in Mammalian DNA Repair
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Replication Licensing and DNA Unwinding: Structure and Function of Mcm2-7"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Charting the Response to DNA Double-Streaks"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
DNA Damage and Repair: Longevity and Quality of Life
9:00 am - 9:20 am
"Regulation of Transcription Coupled Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Fe-S Cluster Biogenesis in DNA Repair Proteins: Structural Studies of the CIA Machinery"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"RecQ4, the Odd One Out in the RecQ Helicase Family"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Dual Roles of XPG in Regulating BRCA1 and BRCA2 Functions in Homologous Recombination"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"The AAA-ATPase VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double Strand Break Repair"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Are TLS Polymerases Absolutely Required for Interstrand Crosslink Repair?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Basic Mechanism to Lethal Weapons
7:30 pm - 7:50 pm
"New Insight on DNA Polymerase Mechanism from Chemical and Structural Biology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Regulation of DNA2 in DNA Repair"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Targeting Cancers with DNA Repair: Beyond BRCA"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Targeting MTH1 to Poison DNA with Oxidized Nucleosides: Beyond Cancer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication Fork Progression and Mutation Avoidance
9:00 am - 9:20 am
"Identification of a Novel Replication Fork Protection Factor that Is Mutated in Microcephalic Primordial Dwarfism"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanism of Replication-Associated Genome Rearrangement"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"DNA2 Facilitates Centromeric DNA Replication for Human Genome Stability"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"DNA Damage Response During Replication Stress"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Reconstitution of RNA Transcript-Mediated DNA Recombinational Repair"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Deciphering the Sliding Activity of MutS Family Proteins in Mismatch Repair"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Homologous Recombination Factors in Replication Stress Response"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations: The Frontiers of Mammalian DNA Repair in 2017
Speakers in this session were selected from abstract submission.
7:30 pm - 7:50 pm
"Coupling of Homologous Recombination and the Checkpoint Response by ATR"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mutagenic Translesion DNA Synthesis and Chemotherapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"TIRR, a New Player in DSB Repair, Regulates 53BP1 Activity by Masking Its Methyl-Lysine Binding Function"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Single Cell Whole Genome Sequencing: Insights for Mammalian DNA Damage and Repair"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage Signaling and Repair Coordination
9:00 am - 9:20 am
"Alternative Mechanisms of Homology Directed DNA Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Phosphorylated CtIP Functions as a Co-Factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Role of ATM, DNA-PKcs and ATR in DNA Repair – Reach Beyond Signaling"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
"Sequential Phosphorylation of Mre11 by ATM and ATR Is Important for DNA Damage Responses"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"RNA Meets DNA: Transcription-Mediated Genome Instability"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Ubiquitination Signaling in Double Strand Break Repair"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mechanisms for DNA Double-Strand Break Repair
7:30 pm - 7:50 pm
"Single Molecule Studies of Homologous DNA Recombination"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Synthetic Viability and Lethality in BRCA Deficient Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Characterization of DNA Double-Strand Break Repair in Human Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Single-Molecule Views of Eukaryotic DNA Resection"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Structures and Genome Stability
9:00 am - 9:20 am
"Regulation of DNA Repair Within the Chromatin Environment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Epigenome Maintenance in Response to DNA Damage"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"The PBAF Chromatin Remodelling Complex and the Maintenance of Genome Stability"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Uncovering How Oxidative DNA Damage Influences Telomere Maintenance"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"RADX Promotes Replication Fork Stability and Modulates Chemosensitivity by Regulating RAD51"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Dark Side of DNA Repair: Repeat Expansion in the Fragile X-Related Disorders"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Crosslinks and Cross Talk
7:30 pm - 7:50 pm
"Replication Fork Encounters with Absolute Blocks to Replication"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Physical and Functional Interactions Between SLX4 and RTEL1"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Resolution of Topoisomerase DNA-Protein Crosslinks"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"ATRX Cooperates with PCNA During Homologous Recombination"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Chromatin Modifications at the Stalled Replication Fork"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure