Genome Maintenance: Mechanisms of Repair, Consequences of Failure for Human Disease and Opportunities for Therapeutic Intervention

Our genome is constantly challenged by environmental and endogenous sources of DNA damage and replication stress. A multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genome stability. However, failures do happen resulting in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair GRC and associated GRS will bring together diverse researchers studying the mechanisms that maintain genome stability and the consequences for human health when these mechanisms fail. In addition, the conference will explore opportunities that DNA repair and signaling networks provide for therapeutic intervention, and discuss how we can harness these DNA metabolism pathways for genome editing.

A diverse cadre of invited speakers will present new discoveries, approaches, and concepts at the frontier of mammalian DNA repair. Additionally, multiple speakers will be selected from abstract submissions and vigorous poster sessions will provide opportunities for sharing participant’s latest research. This GRC will continue a strong tradition of welcoming young scientists, connecting new and senior members of the field, and engaging all participants in discussion through an open atmosphere of scientific exchange.

Applications from investigators interested in all aspects of DNA metabolism and genome stability from basic mechanisms to clinical intervention are encouraged. Trainees are encouraged to attend this GRC and the associated GRS.