Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: New Frontiers in DNA Repair
7:40 pm - 8:25 pm
"ATM, DNA Damage, and Cerebellar Neurodegeneration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"DNA Repair Protection From Transcriptional Stress and Cachexia"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Repair in Telomeres and Repetitive Sequences
9:00 am - 9:20 am
"Mechanisms and Regulation of Repair at Telomeres"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms That Resolve G-quadruplex Structures in Our Genome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Investigating the Chromosomal Instability Signature Induced by LINE-1 Retrotransposition"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Break-induced Replication Orchestrates Resection-dependent Template Switching to Bypass Obstacles"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"DNA Repair in Centromeres"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Unique Features Telemore DNA in Alt-Positive"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Oxidative and Replicative Stress at Telomeres"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Hidden in Our Own Genome: A Previously Missing Link Between EBV and Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single Molecule Approaches in DNA Repair
7:30 pm - 7:50 pm
"Exploring How Proteins Find and Repair Damaged DNA"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Single Molecule Studies of Homologous DNA Recombination"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"New Structural Insights into DNA Replication and Repair Protein Action"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"ATPase Dead?: What this Means for PMS2 During Mismatch Repair"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Regulatory Elements Encoded in TFIIH for Transcription and DNA Repair"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
CRISPR and Chromosome Break Repair
9:00 am - 9:20 am
"Mapping the Cellular Determinants of Genome Editing in Human Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Impact of Transcription and RNA on DNA Break Repair"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Resection Extension Factor-1 (REF-1) Links DNA Double-strand Break Repair to 22q11.2 Distal Deletion Syndrome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Phase Separation of 53BP1 in DNA Damage Response"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"CRISPR Based Genome Editing to Study DNA Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"RAD51 Paralog Function in DNA Damage Tolerance"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Inhibition of RAD51-mediated Template Switching Restores Double Strand Break Signaling in FBH1-Deficient Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Herpes Simplex Virus Manipulates Host DNA Repair Pathways for Productive Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Replication Induced DNA Damage
7:30 pm - 7:50 pm
"Integrator Prevents Transcription-Replication Conflicts to Maintain Genome Stability"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"When Forks Meet the Cytoskeleton - A Function of Myosin VI in DNA Replication Stress and Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Replication Stress in Human Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Replication Fork Uncoupling Causes Nascent Strand Degradation and Fork Reversal"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"ATAD5 Protects Genomic Integrity by Regulating Transposable Elements in Mouse ESCs and Early Embryos"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Excision Repair
9:00 am - 9:20 am
"ET743 Blocks XPG Incision in Transcription-Coupled Nucleotide Excision Repair to Induce ssDNA Breaks in Highly Transcribed Genes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"DNA Glycosylases in Base Excision Repair"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Base Excision Repair in Chromatin: A Tug of War for DNA Damage"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"IDAP, A Novel Tool to Identify DNA Associated Proteins"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Dark Side of Mismatch Repair: Function and Mechanism of MutSß in Promoting Triplet Repeat Expansion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Connecting Spliceosome Quality Control to Genome Integrity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Comparing Mutational Profiles of XPD-mutated Trichothiodystrophy and Xeroderma Pigmentosum Human Fibroblasts After UVB Irradiation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Transcription-coupled DNA Repair in a Test Tube"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage, Repair and Immune Signaling
7:30 pm - 7:50 pm
"Base Excision Repair Protection From Autoimmune Disease"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Base Excision Repair Defects in Neurogenerative Disease"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Replication Stress and R-loops in Immune Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"BRCA-Linked Mechanisms and New Therapeutic Approaches"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Targeting DNA Damage Responsive Pathways in Cancer Therapy"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Targeting DNA Repair in Therapeutics
9:00 am - 9:20 am
"Targeting Telomere Homology Directed Repair in ALT Tumors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Replication Gaps in Mediating PARP Inhibitor Sensitivity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"New Targets in DNA Double Strand Break Repair"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Base Excision Repair Regulation of Replication Stress Induced Poly(ADP-ribose) Checkpoints"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"CDK12 Deficiency in Cancer and Sensitivity to PARP/ATR Inhibitor Combinations"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Establishment of a Complex Organ on a Chip Bone Marrow Model for Predicting Toxicity of Chemotherapeutic & DNA Damage Response Targeting Agents"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Targeting DNA Polymerase Theta in Cancer Therapy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Flap Endonuclease 1 Repairs DNA-protein Crosslinks via PARP1-mediated ADP-ribosylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage in Aging and Disease
7:30 pm - 7:50 pm
"DNA Damage and Repair in Inflammatory Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Arginine Methylation is a Critical Regulator of DNA Replication and Genome Stability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Deficiency in Mammalian STN1 Promotes Colon Cancer Development by Inhibiting BER"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The Mutation Burden of Scleroderma"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"DNA Polymerase Ribonucleotide Incorporation Disrupts m6A Profiles in mRNA to Modulate DNA Repair Gene Expression"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure