Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Chromosome Instability
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Mutational Processes Driving Rapid Genome Evolution"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Protecting the Genome by Homologous Recombination"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromosomal Breaks: Mechanisms and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Targeting MMEJ for the Treatment of HR-Deficient Cancers"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"KU Unleashed: Adaptation and Exaptation from Non-Homologous End-Joining and Beyond"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Unraveling A-EJ and DDR Mechanisms Through V(D)J Recombination"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"BRCA1-A complex restricts chromatin remodeling dependent replication fork resection in ATM-deficient cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mechanism of End Joining Pathways for Double Strand Break Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Regulation of MRE11 with Implications on Genome Stability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"CIP2A is Required to Recruit the SMX Complex to Mitotic Replication Stress Lesions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Guardians of Mitosis: CIP2A-TOPBP1 Driven Mitotic Regulation of MiDAS and MMEJ"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biochemical Reconstitution of DNA Repair
7:30 pm - 7:50 pm
"Multifaceted Role of BRCA1-BARD1 in Homologous Recombination Licensing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Understanding the Mechanism of Trinucleotide Repeat Expansion Through Biochemical Reconstruction"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Structural and Molecular Basis of PCNA-Activated FAN1 Nuclease Function in DNA Repair"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"PCNA Encircling Primer/Template Junctions Is Eliminated by Exchange of RPA for Rad51: Implications for the Interplay Between Human DNA Damage Tolerance Pathways"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Tale of Two RAD51 Paralog Complexes"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Repair in Telomeres and Repetitive Sequences
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Base Excision Repair of Oxidative Damage at Telomeres"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Regulation of transcription-dependent homologous recombination repair"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Lessons from a Combinatorial CRISPR Screen: From Telomere Protection to the Response to Irradiation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"RNA Transcripts Serve as a Template for Double-Strand Break Repair in Human Cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"CHAMP1 Complex Directs Heterochromatin Assembly and Promotes Homology-Directed DNA Repair"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Maintaining Balance: Safeguarding the Centromeric DNA Integrity and Function"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Evolution of Cells Progressing Through Replicative Crisis to Immortality"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Excision Repair and Genome Integrity
7:30 pm - 7:50 pm
"Exploiting Endogenous Base Damage to Enhance Therapeutic Utility of PARP Inhibitors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"ADP-Ribosylation Signalling in Regulation of Genome Stability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Deciphering the Mechanisms of Transcription Factor-Mediated DNA Damage Formation and Repair"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Function of DNA Repair Machineries in Circular DNA Biogenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Basis for the Stimulation of a DNA Repair Nuclease by CSB"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage and Disease: Etiology and Therapeutics and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"BRCA Structure and Function in Disease and Inflammation: A Tale of Two Genome Instabilities"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Regulation of the Fanconi Anemia DNA Repair Pathway"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Acute BRCAness Induction and PARP Inhibition in Prostate Cancer"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"The DNA Damage Response Pathway is Required for Multiciliated Cell Differentiation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Charting DNA Damage and DNA Repair Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Beyond BRCA: An Explanation for the PARP Inhibitor Response of ATM-Deficient Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanism of Fork Breakage During Replication Catastrophe"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Homologous Recombination Promotes Non-Immunogenic Mitotic Cell Death Upon DNA Damage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage, Repair and Immune Signaling
7:30 pm - 7:50 pm
"The Interplay Between the DNA Damage Response Pathway and the Innate Immune System in Mitosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Micronuclear Proteomes are a Window to Mechanisms of Genomic Instability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Causes and Consequences of Replication Stress"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mechanisms of Chromothripsis from Mitotic Errors and Micronuclei"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chromatin Determinants of Replication and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Homology Search in 3D Genome"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Hijacking Centromeric Factors to Limit Mitotic DNA Synthesis at ALT Telomeres"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Multigenerational Single Cell Tracking to Study Principles of DNA Damage Inheritance"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Mechanisms for Heterochromatin Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dissecting the Role for Heterochromatin and Inter-Chromosomal Interactions in Short Tandem Repeat Instability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Epigenetic Landscape Modulates Smoking-Induced DNA Damage Formation, DNA Repair and Mutagenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Methylglyoxal-Induced DNA Damage and Mutagenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Replication Coupled Repair
7:30 pm - 7:50 pm
"Regulation of DNA Replication Stress by Nucleases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Mechanism of Cell-Free Transcription-Coupled Nucleotide Excision Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mechanisms of Break Induced Replication"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mechanism for Local Attenuation of DNA Replication at Double-Strand Breaks"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Regulation of Error-Free and Error-Prone Repair at Stalled Mammalian Replication Forks"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure