Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Chromosome Instability
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Mutational Processes Driving Rapid Genome Evolution"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Protecting the Genome by Homologous Recombination"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromosomal Breaks: Mechanisms and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Targeting MMEJ for the Treatment of HR-Deficient Cancers"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"KU Unleashed: Adaptation and Exaptation from Non-Homologous End-Joining and Beyond"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of MRE11 with Implications on Genome Stability"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Mechanism of End Joining Pathways for Double Strand Break Repair"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biochemical Reconstitution of DNA Repair
7:30 pm - 7:50 pm
"Multifaceted Role of BRCA1-BARD1 in Homologous Recombination Licensing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Understanding the Mechanism of Trinucleotide Repeat Expansion Through Biochemical Reconstruction"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Harmony in DNA Repair: Coordinated Protein and DNA Movements"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Repair in Telomeres and Repetitive Sequences
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Base Excision Repair of Oxidative Damage at Telomeres"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Short Talk Selected from Poster Abstracts
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Lessons from a Combinatorial CRISPR Screen: From Telomere Protection to the Response to Irradiation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Maintaining Balance: Safeguarding the Centromeric DNA Integrity and Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Hijacking Centromeric Factors to Limit Mitotic DNA Synthesis at ALT Telomeres"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Excision Repair and Genome Integrity
7:30 pm - 7:50 pm
"Exploiting Endogenous Base Damage to Enhance Therapeutic Utility of PARP Inhibitors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"ADP-Ribosylation Signalling in Regulation of Genome Stability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Function of DNA Repair Machineries in Circular DNA Biogenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage and Disease: Etiology and Therapeutics and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"BRCA Structure and Function in Disease and Inflammation: A Tale of Two Genome Instabilities"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Regulation of the Fanconi Anemia DNA Repair Pathway"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Charting DNA Damage and DNA Repair Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Beyond BRCA: An Explanation for the PARP Inhibitor Response of ATM-Deficient Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage, Repair and Immune Signaling
7:30 pm - 7:50 pm
"The Interplay Between the DNA Damage Response Pathway and the Innate Immune System in Mitosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Micronuclear Proteomes are a Window to Mechanisms of Genomic Instability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Causes and Consequences of Replication Stress"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mechanisms of Chromothripsis from Mitotic Errors and Micronuclei"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chromatin Determinants of Replication and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Homology Search in 3D Genome"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Epigenetic Mechanisms for Heterochromatin Repair"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Dissecting the Role for Heterochromatin and Inter-Chromosomal Interactions in Short Tandem Repeat Instability"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Replication Coupled Repair
7:30 pm - 7:50 pm
"Regulation of DNA Replication Stress by Nucleases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Mechanism of Cell-Free Transcription-Coupled Nucleotide Excision Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure