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Mammalian Reproduction

Gordon Research Conference

From Regulatory Mechanisms to Practical Applications

August 14 - 19, 2022

Chairs

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Vice Chairs

and

Conference Description

This conference will highlight cutting edge advances in reproductive biology, including gametogenesis, endocrine function, ovarian and testis biology, uterine function, placentation, reproductive tract development, and parturition. Basic, translational, and clinical research on human and animal health will be featured in the form of plenary seminars, short talks selected from submitted abstracts, and poster sessions. The GRC offers a unique program that is designed specifically to bring together researchers of diverse and multi-disciplinary backgrounds who are at all stages of their careers.

Immediately preceding the GRC will be the Gordon Research Seminar (GRS), a forum hosted by and for graduate students, postdocs, and other early-stage scientists. Trainees are encouraged to attend both the GRC and GRS!

Related Meeting

This GRC will be held in conjunction with the "Mammalian Reproduction" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Building Blocks for Reproduction: Eggs, Sperm and Uterus Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"Female Reproductive Aging: Perspectives from the Gamete and Beyond"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Form Follows Function: Anatomical, Functional and Regulatory Duality in the Male Gonad"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"Ode to Uterine Glands: Insights into Development and Function from Animal Models to Organoids"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Stem Cells in Reproductive Processes Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Postnatal Maturation of Spermatogonial Stem Cells and their Niche"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Spatial Transcriptomics Reveals Organizing Principles of the Spermatogonial Stem Cell Niche"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:40 am	"Putative Human Spermatogonial Stem Cells are Molecularly Heterogeneous with Distinctive Functional Potential"
10:40 am - 10:45 am	Discussion
10:45 am - 11:10 am	"Investigating Early Placenta Development with Stem Cells"
11:10 am - 11:20 am	Discussion
11:20 am - 11:30 am	"Preeclampsia Modeling by Using Trophoblast Stem Cells Derived From Umbilical Cords of Affected Infants"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	"A Novel Cell Population From Hindlimbs Interacts with Mesenchymal Cells in the External Genitalia to Facilitate Proper Penis Formation"
11:45 am - 11:50 am	Discussion
11:50 am - 11:55 am	General Discussion
11:55 am - 12:20 pm	"Engineered Biomimetics to Promote Folliculogenesis In Vitro and In Vivo"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Developmental Biology and Sex Determination Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Novel Insights into Sexual Differentiation of Reproductive Tracts: Testicular Hormones and Beyond"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Linking Heterogeneity in Fetal Development to Oocyte Fate and Fitness"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Using CRISPR-Cas9 Technology to Generate Single-Sex Mouse Litters"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Internal and External Influences on Reproduction Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Manipulating and Understanding the Maternal-Fetal Interface: From Nanoparticles to Multiomics"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Perinatal Development of Glucose Intolerance through Tissue-Specific Programming"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Single-Nucleus Atlas of the Choriodecidual Interface Identified Fetal Fibroblasts as the Main Driver of Labor Inflammation"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"Spermatogonial Stem Cells"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	"Robust In Vitro Maturation of Oocytes from Ovarian Tissue, Using Principles of In Vitro Gametogenesis"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Investigating the Relationship Between Morphogenesis and Functional Differentiation of the Mammalian Ovary"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Bioengineering for Improving Reproductive Outcomes Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Uterus Transplant: Innovation in Clinical Care and Research"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Discovery of Evolutionarily Conserved Core Regulators of Spermatogenesis using Multispecies Transcriptomics and Genome Engineering"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 8:55 pm	General Discussion
8:55 pm - 9:20 pm	"Reconstitution of Gametogenesis using Pluripotent Stem Cells"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Immune Function in Reproductive Biology Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"The Sertoli Cell Immune Microenvironment"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Defending the Epididymal Mucosa: Role of Proton-Secreting Cells and Mononuclear Phagocytes"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Testicular Macrophages are Recruited During a Narrow Fetal Time Window and Promote Organ-Specific Developmental Functions"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"Origin of Uterine Tissue-Resident Natural Killer Cells"
11:30 am - 11:40 am	Discussion
11:40 am - 11:50 am	"IL10 Appears to Suppress Protective Immune Responses to SARS-CoV-2 During Pregnancy"
11:50 am - 11:55 am	Discussion
11:55 am - 12:20 pm	"Parturition and innate immune cell activation by fetal DNA"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Reproduction in the Age of Omics Discussion Leaders:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Omics Down on the Farm: Insights into Paternal and Maternal Factors Affecting Pregnancy Establishment in Cattle"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Mapping the Human Female Reproductive Tissue One Cell at a Time"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Tripartite Role for a Single Transcription Factor in Germ Cells"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Molecular and Genetic Control of Reproduction Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"How Ion Channel Modulation Impacts Pregnancy Outcomes"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Progesterone Signaling in Oviductal Epithelial Cells Regulates the Inflammatory Response During Preimplantation Embryo Development"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	"Mouse Ovarian RNA Modification Landscape during Reproductive Aging"
10:25 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"The Regulation of Male Fertility by Pachytene piRNAs"
11:30 am - 11:40 am	Discussion
11:40 am - 11:50 am	"STRA8-Rb Interaction Initiates S Phase Entry and Meiosis in Female Germ Cells"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Investigating the Role of TAF4b in Regulating the Critical Progression Through Prophase I in XX Embryonic Mouse Oocytes"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Role of AGO Proteins in Sex Chromosome Inactivation During Spermatogenesis"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Determinants of Reproductive Outcomes and Disease Discussion Leaders: and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:20 pm	"Genetics of Reproduction: What We Know and Don’t Know"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 9:10 pm	"NOTCH1 – A Friend for Implantation and a Foe for Endometriosis"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Michigan State University - College of Natural Science

Michigan State University - AgBioResearch

Michigan State University - Senior Vice President for Research Innovation

Michigan State University - Pathobiology and Diagnostic Investigation

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD102099. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Mammalian Reproduction (GRS)

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