Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Integrated Systems in Reproduction
Discussion Leader: Indrani Bagchi (University of Illinois at Urbana-Champaign, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Adrian Erlebacher (University of California San Francisco, United States)
"Mechanisms of Gestation Length Timing in Mice"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Sue Hammoud (University of Michigan, United States)
"Balancing Act: Equalizing Sex Specific CENP-A levels is Critical for Mammalian Embryogenesis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Humphrey Yao (National Institute of Environmental Health Sciences, NIEHS/NIH, United States)
"Untangle the Sex Differentiation Multiverse of Embryonic Germ Cells and Gonadal Somatic Cells"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sex Determination and Reproductive Tract Development
Discussion Leader: Eric Pailhoux (INRAE - French National Research Institute for Agriculture, Food and the Environment, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Carolina Jorgez (Baylor College of Medicine, United States)
"Understanding Male Reproductive Tract Development Through Chromosomal Imbalances"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Nitzan Gonen (Bar Ilan University, Israel)
"How to Enhance Sex Determination?"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Valentina Lorenzi (Wellcome Sanger Institute and EMBL-EBI, United Kingdom)
"Dissecting the Spatiotemporal Development of the Human Reproductive Tract Through the Lens of Single-cell and Spatial Genomics"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Myles Bartholomew (Brown University, United States)
"Quiescence and Chromatin Regulation During Male Embryonic Germ Cell Development"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Serge Nef (University of Geneva, Switzerland)
"Studying Neglected Cell Populations of the Developing Gonads and Their Functions"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Ezra Levy (Princeton University, United States)
"Dynamics of Mammalian Germline Cyst Formation"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Dilara Anbarci (Duke University, United States)
"“Splitting Images”: Parallels of the Reproductive Tract Development Reveals Wolffian and Müllerian Contributions to the Rete Structures"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Margaret Petroff (Michigan State University, United States) and Folami Ideraabdullah (University of North Carolina at Chapel Hill, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Bioengineering Approaches to Fertility Preservation and Development
Discussion Leader: Benjamin Beaton (Genus plc, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Mijo Simunovic (Columbia University, United States)
"Recapitulating Early Human Development with Stem Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Cassy Spiller (The University of Queensland, Australia)
"Cripto Promotes Pluripotency and Malignancy of the Male Germline in Mice"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Monica Laronda (Ann & Robert H Lurie Children's Hospital of Chicago (Lurie Children's), and Northwestern University, United States)
"Bioengineering an Ovarian Microenvironment Informed by the Human Ovary BioMolecular Atlas"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Stephanie Tanis (Cornell University, United States)
"Disruption of Reproductive Function in vivo and ex vivo Using a Novel CRISPR/Cas13d Mouse Model"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Cole McCutcheon (Duke University Medical Center, United States)
"Swine Trophoblast Organoids As a Robust, Physiologic Model of Porcine Placental Development"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Pushing the Envelope from Stem Cells to Gametes and Beyond
Discussion Leader: Alta Charo (University of Wisconsin, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Amander Clark (University of California, Los Angeles, United States)
"Engineering Ovarian Cells and Tissues from Pluripotent Stem Cells"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Mitinori Saitou (Kyoto University, Japan)
"Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Harriet Fitzgerald (Hudson Institute of Medical Research, Australia)
"Defining the Dysregulated Endometrial Hormone Response in Endometriosis-associated Infertility"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Magdalena Zernicka-Goetz (California Institute of Technology, United States)
"The Principles of Self-Organization in Early Embryos and Their Stem Cell-Based Models"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Jay Zussman (University of California, San Francisco, United States)
"Quantifying Germ Cell Lineage Dynamics in Mammalian Oogenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Andrew Pask (University of Melbourne, Australia)
"Bringing Back the Past to Protect the Future; Deextinction of the Tasmanian Tiger"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Environmental Impacts on Reproduction
Discussion Leader: Pauliina Damdimopoulou (Karolinska Institutet, Sweden)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
Niels Skakkebaek (Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark)
"Testicular Germ Cell Cancer as a Late Symptom of Testicular Dysgenesis"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
Folami Ideraabdullah (University of North Carolina at Chapel Hill, United States)
"Defining Mouse Germline Epigenetic Diversity Driven by Diet Composition"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Daniel Spade (Brown University, United States)
"Quantifying Low-Dose Toxicant Effects on Germ Cells: Phthalates and Ethylene Glycol Monomethyl Ether"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Hormonal Signaling, Reproductive Cancers and Aging
Discussion Leader: Francesca Duncan (Northwestern University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Francesco DeMayo (National Institute of Environmental Health Sciences, NIH, United States)
"The Role of Progesterone Receptor Isoforms in Uterine Function"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Kathryn Grive (Women & Infants Hospital of RI/Brown University, United States)
"Essential Roles for Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Function in Mammalian Oocyte Proteostasis and Ovarian Function"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Alaina Houghton-Chamberlain (University of Wisconsin - Madison, United States)
"IRX3 and IRX5 Foster Healthy Oocyte-Pre-Granulosa Cell Interactions During Germline Cyst Breakdown and Primordial Follicle Formation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
David Pepin (Massachusetts General Hospital, Harvard Medical School, United States)
"Mechanisms of Action of AMH in the Ovary and Its Application to Contraception"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Grace Foley (Northwestern, United States)
"Single Nuclei Analysis of Serous Endometrial Tumors Reveals Racial Differences in Immune Signaling"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Kara McKinley (Harvard University / Howard Hughes Medical Institute, United States)
"Regeneration in the Uterus"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Fetal-Maternal Interactions on Pregnancy Outcomes
Discussion Leader: Gregory Johnson (Texas A&M University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
Samuel Antwi Oppong (University OF Ghana Medical School, Ghana)
"Transitioning from Single to Multi-disciplinary Care for Pregnant Women with Sickle Cell Disease in Ghana: Impact on Maternal Mortality Rate"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
Rafael Domingues (The Ohio State University, United States)
"Impacts of Antidepressants on Pregnancy Outcomes: Modulation of Placental Perfusion and Function"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
M.Sofia Ortega (University of Wisconsin-Madison, United States)
"Paternal Regulation of the Preimplantation Embryo"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Defense Mechanisms in Healthy Reproductive Tissues
Discussion Leader: Chris Geyer (East Carolina University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Tony De Falco (Cincinnati Children's Hospital Medical Center, United States)
"Sex-Specific Macrophage Origins and Functions in Gonadal Development and Gametogenesis"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Gregory Burns (Michigan State University, United States)
"Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Ryan Marquardt (National Institute of Environmental Health Sciences, United States)
"Serum Response Factor Controls the Uterine Inflammatory Environment for Early Pregnancy Success"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Soo Hyun Ahn (Michigan State University, United States)
"When Tolerance Fails: Trace Metal Imbalance and Epididymal Fibrosis Contribute to Male Infertility"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Rexxi Prasasya (University of Pennsylvania, United States)
"Unraveling the Regulatory Significance of Sperm Hypomethylated Regions in Mammalian Germline Development"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Reyan Coskun (Washington University in St. Louis School of Medicine, United States)
"Modeling the Effects of the Gut Microbiota of Undernourished Mothers with Environmental Enteric Dysfunction on Vascular Remodeling at the Fetal-Placental Interface"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Tzu-Wen Cross (Purdue University, United States)
"From Gut to Gonads: The Interactions Between Microbiome and Sex Hormones"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Blazing New Paths from Essential Foundations in Reproductive Sciences
Discussion Leaders: James Turner (The Francis Crick Institute, United Kingdom) and Julie Kim (Northwestern University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:50 pm
Teresa Woodruff (Michigan State University, United States)
"Engineering Reproduction"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:40 pm
Anne Ferguson-Smith (University of Cambridge, United Kingdom)
"The Genetics of Epigenetic Variation"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure