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Mammalian Reproduction

Gordon Research Conference

Diverse Strategies to Advance Reproductive Science and Health

July 21 - 26, 2024

Chairs

and

Vice Chairs

and

Rey Don Jaime Grand Hotel

Avinguda de l'Hotel

Castelldefels, Barcelona, Spain

Venue and Travel Information

Conference Description

The Mammalian Reproduction GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Mammalian Reproduction" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Integrated Systems in Reproduction Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"Mechanisms of Gestation Length Timing in Mice"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Balancing Act: Equalizing Sex Specific CENP-A levels is Critical for Mammalian Embryogenesis"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"Untangle the Sex Differentiation Multiverse of Embryonic Germ Cells and Gonadal Somatic Cells"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Sex Determination and Reproductive Tract Development Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Understanding Male Reproductive Tract Development Through Chromosomal Imbalances"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"How to Enhance Sex Determination?"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Dissecting the Spatiotemporal Development of the Human Reproductive Tract Through the Lens of Single-cell and Spatial Genomics"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:15 am	"Quiescence and Chromatin Regulation During Male Embryonic Germ Cell Development"
11:15 am - 11:20 am	Discussion
11:20 am - 11:45 am	"Studying Neglected Cell Populations of the Developing Gonads and Their Functions"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Dynamics of Mammalian Germline Cyst Formation"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"“Splitting Images”: Parallels of the Reproductive Tract Development Reveals Wolffian and Müllerian Contributions to the Rete Structures"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Bioengineering Approaches to Fertility Preservation and Development Discussion Leader:
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:30 pm	"Recapitulating Early Human Development with Stem Cells"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 6:50 pm	"Cripto Promotes Pluripotency and Malignancy of the Male Germline in Mice"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:20 pm	"Bioengineering an Ovarian Microenvironment Informed by the Human Ovary BioMolecular Atlas"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Disruption of Reproductive Function in vivo and ex vivo Using a Novel CRISPR/Cas13d Mouse Model"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Swine Trophoblast Organoids as a Robust, Physiologic Model of Porcine Placental Development"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Pushing the Envelope from Stem Cells to Gametes and Beyond Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Engineering Ovarian Cells and Tissues from Pluripotent Stem Cells"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Defining the Dysregulated Endometrial Hormone Response in Endometriosis-associated Infertility"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"The Principles of Self-Organization in Early Embryos and Their Stem Cell-Based Models"
11:30 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Quantifying Germ Cell Lineage Dynamics in Mammalian Oogenesis"
11:50 am - 11:55 am	Discussion
11:55 am - 12:20 pm	"Bringing Back the Past to Protect the Future; Deextinction of the Tasmanian Tiger"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Environmental Impacts on Reproduction Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:35 pm	"Testicular Germ Cell Cancer as a Late Symptom of Testicular Dysgenesis"
6:35 pm - 6:45 pm	Discussion
6:45 pm - 7:10 pm	"Reproduction in a Chemically Altered Environment: Impacts of Chemicals on Human Ovaries"
7:10 pm - 7:20 pm	Discussion
7:20 pm - 7:45 pm	"Quantifying Low-Dose Toxicant Effects on Germ Cells: Phthalates and Ethylene Glycol Monomethyl Ether"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Hormonal Signaling, Reproductive Cancers and Aging Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"The Role of Progesterone Receptor Isoforms in Uterine Function"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Essential Roles for Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Function in Mammalian Oocyte Proteostasis and Ovarian Function"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	"IRX3 and IRX5 Foster Healthy Oocyte-Pre-Granulosa Cell Interactions During Germline Cyst Breakdown and Primordial Follicle Formation"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"Mechanisms of Action of AMH in the Ovary and Its Application to Contraception"
11:30 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Single Nuclei Analysis of Serous Endometrial Tumors Reveals Racial Differences in Immune Signaling"
11:50 am - 11:55 am	Discussion
11:55 am - 12:20 pm	"Regeneration in the Uterus"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Fetal-Maternal Interactions on Pregnancy Outcomes Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:35 pm	"Mechanisms of Cell-Cell Communication at the Maternal-Fetal Interface"
6:35 pm - 6:45 pm	Discussion
6:45 pm - 7:10 pm	"Impacts of Antidepressants on Pregnancy Outcomes: Modulation of Placental Perfusion and Function"
7:10 pm - 7:20 pm	Discussion
7:20 pm - 7:45 pm	"Paternal Regulation of the Preimplantation Embryo"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Defense Mechanisms in Healthy Reproductive Tissues Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Sex-Specific Macrophage Origins and Functions in Gonadal Development and Gametogenesis"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Serum Response Factor Controls the Uterine Inflammatory Environment for Early Pregnancy Success"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"When Tolerance Fails: Trace Metal Imbalance and Epididymal Fibrosis Contribute to Male Infertility"
11:10 am - 11:20 am	Discussion
11:20 am - 11:30 am	"Modeling the Effects of the Gut Microbiota of Undernourished Mothers with Environmental Enteric Dysfunction on Vascular Remodeling at the Fetal-Placental Interface"
11:30 am - 11:35 am	Discussion
11:35 am - 12:00 pm	"From Gut to Gonads: The Interactions Between Microbiome and Sex Hormones"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Blazing New Paths from Essential Foundations in Reproductive Sciences Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:50 pm	"Engineering Reproduction"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:40 pm	"The Genetics of Epigenetic Variation"
7:40 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD115381. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Mammalian Reproduction (GRS)

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