Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Phytoplankton Chemical Cues and Toxins
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Current Challenges in Marine Chemical Ecology Research: What Happens once Natural Products Leave the Organism that Made Them"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"NCCIH Program Priorities for Marine Natural Products – 2018"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Synthesis of Exposure Risks and Health Effects of the Marine Neurotoxin Domoic Acid from Studies with Fish, Mice, Sea Lions, and Humans"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
"Omic" Methods in Natural Product Research
9:00 am - 9:30 am
"Mining (Meta)genomes for New Peptide Modifications"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Preparative Mass Spectrometry: Novel Synthetic and Reaction Screening Approaches"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Untargeted Metabolomics Integrated with Bioassay Data for Natural Products Dereplication"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Computational Tools for Prioritizing Drug Discovery in Actinomycetes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Exploring the Biosynthetic Potential of Complex Microbial Communities"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Employing Stable Isotope Labeling to Connect Gene Clusters and Their Cognate Products: A Systems Approach"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic and Biosynthetic Advances in Natural Product Research
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
"Natural Product Discovery in Burkholderia thailandensis Through Cryptic Gene Cluster Activation"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
"Bacterial Signals Regulate Multicellularity and Mating in Animals' Closest Relative"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Bioactivity-Guided Retrosynthesis: Progressive SAR and Mode of Action Studies of Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Finding Drugs in the Garden: Mining Plant Chemical Diversity"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Identification and Pre-Clinical Development of Marine Natural Products
9:00 am - 9:30 am
"Biologically Active Metabolites from Marine Organisms and Their Associated Microorganisms"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Strategies for Studying Bioactive Marine Organisms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Labeling Natural Products in Complex Extracts"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Where Are and How to Find the Novel and Bioactive Secondary Metabolites"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Quantum Mechanical Prediction of Chiroptical Properties as an Aid for Structure Elucidation of Natural Products"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"A Chemical Genetics Approach to the Discovery of Marine Natural Product Drug Leads"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developing the Next Generation of Pharmaceuticals
7:30 pm - 8:00 pm
"Anticancer Drugs of Marine Origin in Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Harnessing Genomic Information to Identify Natural Products with Novel Mechanisms of Action"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Mechanisms of Antibiotic Resistance Revealed by Global Genome Mining and Biosynthesis Gene Cluster Manipulation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Anti-Infective Research and Development"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Action and Molecular Targets
9:00 am - 9:30 am
"Marine Natural Products as a Source of New Drugs for Neglected Tropical Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The NCI Program for Natural Product Discovery"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Lessons from Nature in Predicting and Controlling Cell Permeability in Cyclic Peptides"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Secondary Metabolism in the Acid Mine Drainage Microbiome at Ely Copper Mine in Vershire, VT"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Gene Activation Strategies in Marine Endophytic Fungi"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Natural Product Payloads for the Next Generation of Antibody-Drug Conjugates in Clinical Trials"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Chemical Mediated Interactions
7:30 pm - 8:00 pm
"New Directions in Chemical Ecology on Coral Reefs"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Secondary Metabolite Modulation in Host-Symbiont-Pathogen Systems"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Widespread Biosynthesis of Defense Chemicals by Obligate Symbionts of Marine Organisms"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Model System for Antibiotics and the Physiology of Bacterial Competitive Fitness"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Methodological Advances in Natural Product Research
9:00 am - 9:30 am
"Lessons Learned from Mining 10,000 Actinobacterial Genomes for Phosphonic Acid Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Learn from Microbial Intelligence for Avermectin Overproduction"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Tropodithietic Acid Producing Roseobacter Group Bacteria as Probiotics in Marine Aquaculture"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Discovery of the Biosynthesis of Domoic Acid in Pseudo-Nitzschia Diatoms"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Mycale Sponges Inherit Cytotoxin Producers Through Vertical Microbial Transfer"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Interspecies Interactions Between Bacteria Mediate Transcriptional Activation of an Otherwise Silent Biosynthetic Gene Cluster"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Marine Natural Products Research
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"The PharmaSea Project – Key Results and Influence on International Policy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Introduction by Discussion Leader
8:30 pm - 9:15 pm
"Development of Promising Antiparasitic Leads from Marine Cyanobacterial Lipopeptides"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure