Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Cryptic Microbial Metabolites
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"The Ecology and Evolution of Natural Products in Marine Actinobacteria"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Microbial Biosynthesis of Heterocyclic Natural Products"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Unlocking the Chemical Potential of the Fungal Terpenome"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Marine Natural Products as Therapeutics and Molecular Probes
9:00 am - 9:30 am
"Chemistry-First Approach to Identify Novel Targets for Personalized Treatment in Lung Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Evolution and Therapeutic Application of Venom from Predatory Marine Snails"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Considerations for Development and Launch of a Successful Antibody-Drug Conjugate"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Turbinmicin, a New Antifungal with Potent In Vivo Efficacy Against Pan Resistant Candida auris and Aspergillus fumigatus "
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Chemically Rich Sponge Symbiont Identified by Single-Cell Genomics and Raman Microscopy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A SMART Approach for Natural Product Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Tools in the Structure Elucidation Tool Box
7:30 pm - 8:00 pm
"Siderophores in Stereo: Targeting Structural Diversity in the Discovery of New Siderophores"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Preparation and Structural Elucidation of Sesquiterpenoid Marine Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Advanced NMR Methods for Structure Elucidation of Complex Organic Molecules"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Redefining the Role of NMR in the Structure Elucidation of Marine Natural Products"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Secondary Metabolite Biosynthesis, Enzymology and Genomics
9:00 am - 9:30 am
"Understanding the Bottlenecks in Cyanobacterial Natural Product Research"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Computational Omics of Microbial Biosynthetic Diversity: From Natural Product Discovery to Microbiome Ecology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Biocatalysis and Complex Molecule Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Ascidian Microbiome Metagenomics: In Search of the Palmerolide Biosynthetic Gene Cluster"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Progress in α-N -Methylated RiPP Biosynthesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Synthase-Guided Single Cell Genomics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enhanced Screening and Discovery Platforms for Natural Products
7:30 pm - 8:00 pm
"National Program for Natural Product Discovery, Generation of a Prefractionated Library for High Throughput Screening"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Genomic and Spectroscopic Signature-Based Discovery of Bioactive Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"IDBac: Bioinformatics Software for Microbial Drug Discovery Prioritization and Culturomics Characterization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Genome Mining-Guided Insights into Beta-Lactone Natural Product Biosynthesis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Application of New Enabling Technologies
9:00 am - 9:30 am
"Crystalline-Sponge Method for Natural Products Chemistry and Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Visualizing Chemical Communication in Host-Microbe Interactions with Imaging Mass Spectrometry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"New Methods Enabling the Synthesis and Characterization of Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"DU8+: Structure Validation/Revision Made Easy with Fast and Accurate Computations of Nuclear Spin Coupling Constants and Chemical Shifts"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Total Synthesis of THF-Containing Marine Macrolides"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Development of NMR Tools to Discover Unique Natural Products in Complex Mixtures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mechanisms of Action and Molecular Targets
7:30 pm - 8:00 pm
"Pheno-Target Drug Discovery from Natural Products Using Native Mass Spectrometry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"A Multidimensional Profiling Platform to Unlock the Mechanisms and Therapeutic Potential of MNPs"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The NP3 Approach for Capture and Validation of Protein-Targeted Bioactive Natural Products: Recent Advances Using Marine Natural Products"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Metabolomics and Mass Spectrometry-Based Bioassay Development for Compound Discovery from Harmful Algal Blooms"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional and Ecological Roles of Natural Products
9:00 am - 9:30 am
"Mesophotic Marine Ecosystems: Inspiring Understudied Resource"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Interspecies Chemical Sensing in an Evolutionary Model and Potential Biocontrol Agent"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Chemoproteomic Approach for Target Discovery of Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Multi-Year Investigation into the Secondary Metabolite Composition of Trichodesmium Blooms"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Deep-Sea Coral Microbiomes as a Source for Novel Natural Products"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Genetic and Biochemical Reconstruction of Ozone-Depleting Bromoform Production by Marine Macroalgae"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Marine Natural Products Discovery
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Expanding Marine Natural Product Genome Mining and Synthetic Biology Horizons"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Introduction by Discussion Leader
8:30 pm - 9:15 pm
"Sea Slugs, Slime and Coral Diseases: Chemical Ecology and Our Changing Ocean"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure