Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Developing Marine Natural Product Therapies
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Host-targeted Antiviral Development, Treating the Current Pandemic and Preparing for the Next"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Thioesterase-Mediated O-Acetylation and Double Bond Formation in Peloruside Biosynthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Marine Natural Products and Antibody Drug Conjugates: A Journey from the Ocean’s Deep to the Clinic"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Climate Change, Marine Toxins and Environmental Solutions
9:00 am - 9:30 am
"Development of Marine-derived Sunscreens and Their Role in Ocean Conservation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Ecological Roles of Brominated Indole Alkaloids within Coccolithophore Blooms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Solving the Mystery of Saxitoxin Biosynthesis in Dinoflagellates: Turn-over, Subcellular Localization and Regulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Life on Plastic: Deciphering the Functions of Marine Microbes in the Plastisphere"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Metabolomics Approaches to Probe Probiotic Potential of Cultured Coral-associated Bacteria"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Metabolomic Insights into Parasite Diseases of Phytoplankton"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Biology for Natural Product Production and Engineering
7:30 pm - 8:00 pm
"Reverse Genetics and Synthetic Biology for Natural Product Discovery and Production"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Posttranslational Cyclophane Formation in Bacteria"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Pinpointing Building Blocks and Amino Acid Ligases in TLN-05220 Biosynthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Terpenoid Biosynthesis in Octocorals"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Biosynthetic Origin of Octocoral Terpenoids"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Super Resolution Imaging for Natural Product Mechanisms
9:00 am - 9:30 am
"Biomining New Tools For Analyzing and Controlling Complex Biological Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mapping Biological Processes Through Molecular Vibrations"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Molecular Basis for Substrate-selective Inhibition of Protein Secretion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"High Resolution MAS NMR Methods for Metabolic Profiling of Intact Zebrafish Embryos Exposed to Harmful Algal Bloom Toxins"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Taking a Microscale Look at Symbiotic Interactions: New Metabolites from the Host–Microbe Interface"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Strategies for Natural Product Lead Development
7:30 pm - 8:00 pm
"Building Biological Performance Diversity and Chasing Challenging Targets for Probe and Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Walking the Non-biogenic Path: Cyanobacterial Pseudo-natural Products"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Bioinspired 3D Printing of Complex Marine Natural Scaffold for Anticancer Lead Discovery"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Chemical Synthesis of Ritterazine B, A Marine Natural Product with Potent Anticancer Activity"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Workflows for Natural Products Discovery
9:00 am - 9:30 am
"Spatial Mass Spectrometry and Data Analysis Approaches for Rational Drug Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"NP-Suite: New Tools to Process, Integrate and Annotate Mass Spectrometry and Bioactivity Data for Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Machine Learning Methods for Discovering Natural Products from Large Mass Spectral Datasets"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Predicting Natural Product Activities with Machine Learning"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Conformational Analysis of Flexible Natural Products Based on Sparse Experimental Restraints"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Digging Through the Data: Pursuing the Ideal Natural Product Discovery Scenario"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Lead Discovery, Molecular Targets and Phenotypic Screening
7:30 pm - 8:00 pm
"Ecology-driven Approaches to Biosynthesis and Drug Lead Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Preclinical Evaluation of Marine Natural Products for Neuroscience Drug Development"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"A Mass Spectrometry-based High-throughput Platform for Natural Product Electrophile Discovery and Biological Screening"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Classifying Drugs Using Morphological Changes in Treated Tubercle Bacilli"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Products in the Context of Microbiomes and Symbioses
9:00 am - 9:30 am
"The Role of Symbioses in Natural Product Discovery: Discoveries from Bacterial Symbionts of Shipworms"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Sugars Dominate the Seagrass Rhizosphere"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"The Biosynthesis of Bacterial Tropone Natural Products Important for Marine Symbiotic Interactions Depends on a Novel Flavoprotein Dioxygenase Prototype"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Small Molecule-mediated Interactions in Symbiotic Systems"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Chemical Investigations into the Microbiota of Marine Egg Masses"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Regulation of Specialized Metabolite Production in Complex Microbiome Systems"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Integrated Strategies for Marine Natural Products Discovery
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Integrating Metabolomics into Mechanism of Action Studies of Marine Natural Products"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
"Challenges and Adventures During Sponge Natural Products Chemistry Discovery at UCSC: The Good, The Bad, and The Ugly"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure