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Marine Natural Products (GRS)

Gordon Research Seminar

Chemical Biology and Drug Discovery from the Marine Environment

February 22 - 23, 2020

Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Marine Natural Products is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present unpublished data and exchange innovative ideas.

This year's meeting will focus on the complexity inherent in natural products research. Talks and posters from a diverse and interdisciplinary group of young scientists will explore marine metabolite structures, their often cryptic biological and ecological roles, and unlocking their potential as translational agents.

Related Meeting

This GRS will be held in conjunction with the "Marine Natural Products" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Bioactive Peptides from Philippine Marine Organisms Dr. Lilibeth Salvador heads the Marine Pharmacognosy Lab at the Marine Science Institute at the University of the Philippines, Diliman. After completing her doctorate in Pharmaceutical Sciences - Medicinal Chemistry at the University of Florida under the mentorship of Dr. Hendrik Luesch, she returned to UP Diliman to advance the marine natural products research capacities of the Philippines. Discussion Leader:
3:45 pm - 4:15 pm	"Bioactive Peptides from Philippine Marine Organisms"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Exploring Structural Diversity: Enzymatic and Synthetic Routes to Complex Metabolites Discussion Leader:
7:30 pm - 7:50 pm	"Discovery, Total Synthesis and Bioactivity of Novel Halogenated Depsipeptides"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"The Remarkable Substrate Promiscuity of OspR: A New Ornithine-Generating Maturase Involved in the Biosynthesis of the Cryptic Antiviral Proteusin Natural Product Landornamide A"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Absolute Configuration Determination of Complex Natural Products Using Glycosides as Internal Probes via Quantitative NOE-Based NMR Spectroscopy"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Designing Modular Chassis for the Efficient Production of Complex Bacterial Sesqui- and Diterpenoids"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Genome Mining-Guided Insights into Beta-Lactone Natural Product Biosynthesis"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Cross-Talk: Chemical Interactions in Natural Systems Discussion Leader:
9:00 am - 9:20 am	"Elucidating the Biosynthesis of Penilumamide from a Marine Fungal Endophyte and Exploring the Ecological Role of Its Lumazine Building Block"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Allianthrones A and D: Selective Cytotoxic Bianthrones from Marine Aspergillus alliaceus"
9:50 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Chemical and Biological Investigation of Ikarugamycin"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"A Multi-Year Investigation into the Pseudo-Nitzschia Community Occupying Narragansett Bay, Rhode Island with Emphasis on Environmental Drivers of Domoic Acid Production"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Genome-Mining Guided Isolation of a New Class II Lasso Peptide from Extremotolerant Deep-Sea Pseudomonas sp. SST3 Leading to New Biosynthetic Route for Lasso Peptide Production"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Enabling Technologies: Platform Systems for Natural Product Discovery Discussion Leader:
1:30 pm - 1:45 pm	"IDBac: Bioinformatics Software for Microbial Drug Discovery Prioritization and Culturomics Characterization"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	"Development of a Bacterial Host for Natural Product Discovery and Production"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:25 pm	"NP Analyst: An Open Online Platform for Compound Activity Mapping"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Center For Complementary & Integrative Health of the National Institutes of Health under Award Number R13AT010821. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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