Structure and Function:
J. F. Woessner, Jr., discussion leader
J. F. Woessner, Jr., "An overview."
W. Bode, "Common and different structural properties of the MMPs."
G. Murphy, "The role of domain structures in the MMPs and TIMPs."
H. E. Van Wart, "Mechanistic studies of MMPs."
Activation and Substrate Specificity
H. Nagase, discussion leader
S. M. Krane, "Collagenase and type I collagen resorption."
M. Seiki, "Activation of proMMP-2 by membrane-type MMP."
G. I. Goldberg, "Gelatinase A: mechanism of cell surface activation."
R. A. Black, "Processing of TNF-à by a membrane-associated metalloproteinase."
Inhibition of MMPs
H. E. Van Wart, discussion leader
K. Appelt, "Strategy of designing synthetic inhibitors."
A. J. P. Docherty, " Synthetic gelatinase inhibitors."
M. Visnick and J. J. Birktoft, "Structure based design of stromelysin inhibitors."
R. Williamson, "Solution structure of the N-terminal domain of TIMP-2."
Regulation of Mmp Gene Expression
C. E. Brinckerhoff, discussion leader
J. M. Dayer, "Direct cell-cell contact and MMP production."
P. Angel, "Fos/Jun-dependent expression of MMPs."
C. E. Brinckerhoff, "Transcriptional and posttranscriptional regulation of MMPs."
MMPs in Disease I
A. R. Poole, discussion leader
A. R. Poole, "Collagen degradation in arthritis."
M. W. Lark, "Aggrecan degradation in osteoarthritis.
H. G. Welgus, "Are nonhealing ulcers the consequence of MMP overproduction?"
K. Gijbels, "Multiple sclerosis."
MMPs in Disease II (cancer)
Y. A. DeClerck, discussion leader
W. G. Stetler-Stevenson, "Signal transduction via TIMP-2 receptor modulates fibroblasts cell growth."
P. Basset, "Stromelysin 3: a stromal metalloproteinase."
P. D. Brown, "Preclinical and clinical studies of MMP inhibitors in the treatment of cancer."
C. Lop‚z-Ot¡n, "Structure, function and regulation of collagenase 3."
Development
L. M. Matrisian, discussion leader
Z. Werb, "How MMPs regulate mammary gland structure and function."
K. Tryggvason, "Developmental expression of MMP-2 and MMP-9."
D. R. Edwards, "MMPs and TIMPs during mammalian embryo implantation."
Y.-B. Shi, "MMPs in amphibian metamorphosis."
Selected poster presentations
D. E. Woolley, discussion leader
Physiological Roles of MMPs
H. Birkedal-Hansen, discussion leader
J.-M. Delaiss‚, "MMPs in bone remodelling."
S. Fisher, "MMPs in human trophoblast invasion."
J. A. Madri, "Integrin-mediated MMP expression following T cell-endothelial cell interaction."
M. S. Pepper, "Angiogenesis: mechanism and modulators."
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