SUNDAY, July 13
- 7:30 - Welcome - Lynn Matrisian
Session 1. Matrix Metalloproteinase Structure
- 7:35 - Discussion Leader: Fred Woessner (Florida, U.S.A.)
- 7:50 - Hideaki Nagase (Kansas, U.S.A.) - "Structure-function relationships of MMP-1 and MMP-3"
- 8:20 - Discussion
- 8:30 - Richard Williamson (U.K.) "TIMP structure"
- 8:45 - Discussion
- 8:50 - Wolfram Bode (Germany) - "TIMP-MMP structure and interaction geometry."
- 9:20 - Discussion
- 9:30 - End of Session
MONDAY, July 14
Session 2. Regulation of MMP activity
- 9:00 - Discussion Leader: Motoharu Seiki (Japan)
- 9:15 - Christopher Overall (Canada) - "Gelatinase A Domain functions"
- 9:45 - Discussion
- 9:55 - Steven Weiss (Michigan, U.S.A.) - "Intracellular activation of MMPs"
- 10:25 - Discussion
- 10:35 - Break
- 10:50 - Vera Knauper (U.K.) - "Activation of collagenase-3"
- 11:20 - Discussion
- 11:30 - Suneel Apte (Ohio, U.S.A. ) - "TIMPs-2,3, and 4"
- 12:00 - Discussion
- 12:10 - Nicola Partridge - "Collagenase-3 scavenger receptor"
- 12:25 - Discussion
- 12:30 - End of Session
Poster Group 1: 4:30-6:00
Session 3: Related metalloproteinases
- 7:30 - Discussion Leader: Gillian Murphy (U.K.)
- 7:45 - Judith White (California, U.S.A.) - "ADAMS"
- 8:15 - Discussion
- 8:25 - Karl Kadler (U.K.) - "PCP-1/BMP-1 in tissue assembly"
- 8:55 - Discussion
- 9:05 - Atsuko Fujisawa-Shehara (Japan) - "Meltrin and myotube formation"
- 9:35 - Discussion
- 9:45 - End of Session
TUESDAY, July 15
Session 4. Regulation of MMP expression
- 9:00 - Discussion Leader: Constance Brinckerhoff (New Hampshire, U.S.A.)
- 9:15 - Bryan Toole (Boston, U.S.A.) - "EMMPRIN induction of MMPs"
- 9:45 - Discussion
- 9:55 - Juan Saus (Spain) - "Regulation of stromelysin gene expression"
- 10:25 - Discussion
- 10:35 - Break
- 11:00 - Adriano Henney (U.K.) - "Mutations in the stromelysin promoter and atherosclerosis"
- 11:30 - Discussion
- 11:40 - Rafael Fridman - "The alpha-2 chain of type IV collagen mediates the cell surface association of MMP-9"
- 11:55 - Discussion
- 12:05 - M. Sharon Stack - "A functional link between adhesion and proteolysis"
- 12:20 - Discussion
- 12:25 - End of Session
Poster Session Group 1 continued: 4:30-6:00
Session 5. MMPs in normal systems
- 7:30 - Discussion Leader: Zena Werb (California, U.S.A.)
- 8:00 - Gary Ciment (Oregon, U.S.A.) - "Role of MMP-3 in axonal growth within the nervous system"
- 8:30 - Discussion
- 8:40 - Lois Salamonsen (Australia) - "Endometrial remodelling: Menstrual cycle events"
- 9:10 - Discussion
- 9:20 - Jean-Marie Delaissé - "Osteoclast migration"
- 9:35 - Discussion
- 9:40 - End of Session
WEDNESDAY, July 16
Session 6. MMPs in disease states
- 9:00 - Discussion Leader: Henning Birkedal-Hansen (Washington, D.C., U.S.A.)
- 9:15 - Peter Libby (Mass. U.S.A) - "Potential role of proteases in vascular remodeling"
- 9:45 - Discussion
- 9:55 - Lieve Moons - "uPA activation of MMPs in atherosclerosis"
- 10:10 - Discussion
- 10:15 - Break
- 10:45 - William Parks (Missouri, U.S.A.) - "Wound healing"
- 11:15 - Discussion
- 11:25 - Elizabeth Fini - "Role and regulation of Gel B in wound healing"
- 11:40 - Discussion
- 11:45 - Paul Soloway - "Complement-dependent hyperimmunity in TIMP-1-deficient mice"
- 12:00 - Discussion
- 12:05 - New Metalloproteinases - general participation
- 12:30 - End of Session
Poster Session Group 2: 4:30-6:00
Session 7. Metalloproteinases in inflammation
- 7:30 - Discussion Leader: Stephen Krane (Mass. U.S.A.)
- 7:45 - Marsha Moss (Glaxo, U.S.A.) - "How MMP-like is TACE?"
- 8:15 - Discussion
- 8:25 - Steve Shapiro (Missouri, U.S.A.) - "Metalloelastase"
- 8:55 - Discussion
- 9:05 - David Bradshaw (Roche, U.K.) - "Inhibitors as therapy"
- 9:35 - Discussion
- 9:45 - End of Session
THURSDAY, July 17
Session 8. Metalloproteinases in cancer
- 9:00 - Discussion Leader: William Stetler-Stevenson (Washington D.C., U.S.A.)
- 9:15 - Yasunori Okada (Japan) - "Expression in tumors"
- 9:45 - Discussion
- 9:55 - Rama Khokha (Canada) - "Mechanisms underlying the effects of TIMP-1 on tumorgenesis"
- 10:25 - Discussion
- 10:35 - Break
- 11:00 - Lynn Matrisian - "Surprising roles for MMPs in tumor progression"
- 11:15 - Discussion
- 11:20 - Lisa Coussens - "Activation of proteinases and stromal remodeling in multi-stage neoplastic progression"
- 11:35 - Discussion
- 11:45 - Karen Miller (British Biotech, U.K.) - "MMP inhibitors in cancer therapy"
- 12:15 - Discussion
- 12:25 - End of Session
Poster Session Group 2 continued: 4:30-6:00
Session 9.
- 7:30 - J. Fred Woessner, Jr. - "Historical perspective on the MMP field"
- Elections - Gillian Murphy, Vice Chair
- Award Presentations - Awards Committee and Chris Overall, Chair
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