| Sunday, May 13, 2001 | Arrival and Check-in |
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| 02:00 - 9:00 pm | Arrival |
| 06:00 pm | Dinner |
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Session I: Sunday Evening
07:30 pm - 09:30 pm | MMPs: The Field at a Cross-Road |
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| Chair: Henning Birkedal-Hansen |
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- Carlos Lopez-Otin: "Of Plants, Flies, Worms, Mice and Human MMPs"
- Zena Werb: "MMP Substrates: New and Emerging Paradigms"
- Tyra Wolfsberg: "The Human Genome Project: MMPs and ADAMs"
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| 07:30 am - 08:30 am. | Breakfast |
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Session I: Monday Morning
09:00 am - 12:30 pm | Gene Targeting Approaches to Metalloproteinase and
TIMP Function |
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| Chair: Steve Shapiro |
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- Steven Krane: "The MMP-13 Knock-out Mouse"
- Dylan Edwards: "Profiling Metalloproteinase and TIMP Gene Expression Using TaqMan Quantitative Real-Time PCR."
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| 10:25 am-10:55 am | Coffee Break |
| 10:30 am. | Conference Photo |
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- Rama Khokha: "Apoptosis in Timp-3 Knock-out Mice"
- Kevin Leco: "Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) Deficient Mice Spontaneously Develop Emphysema."
- Hiroki Kurihara: "Lessons From the Gene Knock- out of ADAMTS-1"
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| 12:30 pm - 01:30 pm. | Lunch |
| 01:30 pm - 04:00 pm. | Free From all Formal Activity |
| 04:00 pm - 05:30 pm. | Poster Session I: Chair: Christopher Overall |
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Session II: Monday Evening
05:30 pm - 07:30 pm | TIMP Structure and Function |
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| Chair: William Stetler-Stevenson |
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- Ekaterina Morgunova: "Structure of the MMP-2/TIMP2 Complex"
- Marek Radomski: "Nitric Oxide and the MMP-TIMP Pathways in Regulation of Platelet Function"
- Irit Sagi: "Structural-Spectroscopic studies of human gelatinases reveal aspects in their mode of action"
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| 08:00 pm. | Dinner |
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| 07:30 am - 08:30 am. | Breakfast |
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Session III: Tuesday Morning
09:00 am - 12:30 pm | New MMP Substrates/Novel MMP Functions I |
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| Chair: Hideaki Nagase |
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- Christopher Overall: "New Chemokine Familes as MMP Substrates"
- Richard Shulz: "Degradation of Troponin I by Matrix Metalloproteinase-2 Contributes to Acute Ischemia-Reperfusion Injury of the Heart"
- Patrick Anglard: "A Nuclear Matrix MMP is Directly Translated as an Active Form and Inactivates Serine Proteinase Inhibitor"
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| 10:40 am - 11:10 am | Coffee Break |
- William Parks: "Epithelial-Mediated Control of Inflammation"
- Yibing Yan: "The Metalloproteinase KUZBANIAN Mediates the Transactivation of EGF Receptor by G-Protein Coupled Receptors."
- James Duan: "Novel TACE Inhibitors."
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| 12:30 pm - 01:30 pm. | Lunch |
| 01:30 pm - 04:00 pm. | Free From all Formal Activity |
| 04:00 pm - 05:30 pm. | Poster Session II: Chair: Christopher Overall |
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Session IV: Tuesday Evening
05:30 pm - 07:30 pm | New MMP Substrates/Novel MMP Functions II |
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| Chair: Howard Welgus |
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- Barbara Fingleton: "MMP Processing of TNF-alpha Family Members: Biological Implications"
- Greg Goldberg: "Fractal Model of Substrate Recognition by MMP: The Role of Hemopexin Domain"
- Stephen Nishimura: "The Integrin avb8 Mediates Epithelial Homeostasis through MT1-MMP-Dependent Activation of TGF-b1.
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| 08:00 pm. | Dinner |
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| 07:30 am - 08:30 am. | Breakfast |
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Session V: Wednesday Morning
9:00 am - 12:30 pm | Membrane-Anchored MMPs and Cell Migration I |
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| Chair: Gillian Murphy |
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- Steve Weiss: "Activity and Function of Membrane-Anchored Matrix Metalloproteinases"
- Thomas Stricker: "MMP-1 Binding to a2b1 Integrin."
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| 10:00 am. | Coffee Break |
- Peter Friedl: "Proteolytic and Non-Proteolytic Tumor Cell Migration Strategies"
- Joseph Madri: "The Role of MT1-MMP and MMP-2 in T-Cell Entry"
- Charlotte Morrison: "Activation of Gelatinase A by MT2-MMP in a TIMP Independent Pathway and the Role of TIMP-4 in Gelatinase A Activation by MT1-MMP."
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| 12:30 pm - 01:30 pm. | Lunch |
| 01:30 pm - 04:00 pm. | Free From all Formal Activity |
| 04:00 pm - 05:30 pm. | Poster Session III |
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Session VI; Wednesday Evening
05:30 pm - 07:30 pm | Session VI; Membrane-Anchored MMPs and Cell Migration II |
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| Chair: James Quigley |
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- Motoharu Seiki: "Regulation of MT1-MMP During Cell Migration"
- Alexander Strongin: "Location, Location, Location, or How MT1-MMP is Likely to Affect Signaling and Transcription in Migrating Cells."
- Short talk: To be announced
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| 08:00 pm. | Dinner |
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| 07:30 am - 08:30 am. | Breakfast |
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Session VII; Thursday Morning
09:00 am - 12:30 pm | ADAM/ADAM-TS and "Shed'ases" |
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| Chair: Roy Black |
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- Carl Blobel: "Functional and Biochemical Studies of ADAMs and Their Roles in Protein Extodomain Shedding."
- Rik Derynck: "Regulation of TGF-alpha Ectodomain Release"
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| 10:50 am.- 11:20 am | Coffee Break |
- Suneel Apte: "Molecular and Functional Diversity of the ADAMTS Family"
- John Fessler: "The papilin casette: a molecular bridge for ADAMTS interactions with basement membranes and matrix"
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| 12:30 pm - 01:30 pm. | Lunch |
| 01:30 pm - 04:00 pm. | Free From all Formal Activity |
| 05:30 pm - 07:30 pm. | Business Meeting, Chair: Christopher Overall |
| 08:00 pm. | Dinner |
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| 07:30 am - 08:30 am | Breakfast |
| 09:00 am. | Departure |
