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Matrix Metalloproteinases

Gordon Research Conference

Metalloproteinase Research at the Intersection of Basic Science and Applied Medicine

August 7 - 12, 2011
Chair
Vice Chair
Bryant University
1150 Douglas Pike
Smithfield, Rhode Island, United States
 Venue and Travel Information

Conference Description

The Gordon Research Conference (GRC) on Matrix Metalloproteinases (MMPs) has been held continuously since 1993, and is the premier conference in the field. The GRC on MMPs gathers investigators from multiple disciplines to present and discuss emerging and cutting-edge research in the field of MMPs and the related ADAM and ADAMTS metalloproteases. The 2011 conference will be focused around the theme “Metalloproteinase Research at the Intersection of Basic Science and Applied Medicine” with the goal of promoting discussions and exchange of ideas on how to integrate recent advances in structural, biological, and functional metalloproteinase research with ongoing and emerging clinical applications. The conference will bring together prominent investigators in the field, early-career independent investigators and new investigators around a scientific program that will focus on turning point discoveries, unexpected findings, and the impact of novel technologies on metalloproteinase research. A special session will be dedicated to discuss the new challenges of translating the latest advances on metalloproteinase research, including new developments on metalloproteinase inhibitors, into the clinic. For the first time in the history of this conference, a Gordon-Kenan Research Seminar (GRS) on MMPs will be organized by postdoctoral fellows and graduate students with interest in metalloproteinases, which will be held the weekend prior to the GRC. The 2-day GRS program will provide a unique and exciting forum for young researchers to present their research and discover the GRC experience. Graduate students and postdoctoral fellows conducting research on metalloproteinases are strongly encouraged to participate and present their work at the GRS. We expect that the joint 2011 GRC and GRS on MMPs will enhance crosstalk and cross-fertilization of ideas between scientists and contribute to the ultimate goal of translating these ideas and knowledge into novel therapeutic interventions in human diseases.

Related Meeting

This GRC will be held in conjunction with the "Matrix Metalloproteinases" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNew Developments in Metalloproteinase Research
Discussion Leader: Gillian Murphy (University of Cambridge, UK)
7:40 pm - 8:10 pmCarl Blobel (Cornell University)
"ADAM17, a key molecule in EGF-receptor signaling"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmMotoharu Seiki (University of Tokyo, Japan)
"MT1-MMP is a multidimensional regulator of tumor microenvironment"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmHideaki Nagase (Imperial College London, UK)
"New development in collagenase-collagen interaction"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmUnveiling the Structure-Function Relationship of Metalloproteinases
Discussion Leader: F. Xavier Gomis-Ruth (Molecular Biology Institute of Barcelona, Spain)
9:00 am - 9:20 amF. Xavier Gomis-Ruth (Molecular Biology Institute of Barcelona, Spain)
"Recent advances in the structural characterization of metallopeptidases"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amWalter Stocker (Johannes Gutenberg-University, Germany)
"Activation, specificity and biological control of astacin metalloproteases"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amIrit Sagi (Weizmann Institute of Science, Israel)
"Degradation of super structured protein substrates by MMPs"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amGreg Goldberg (Washington University)
"Mechanism of collagen degradation: single-molecule tracking of MMP1 on Type I collagen fiber"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGregg Fields (Torrey Pines Institute for Molecular Studies)
"Dissecting collagenolysis utilizing triple-helical peptide models"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pm Steven Van Doren (University of Missouri)
"MMP-12 as illustration of subtle tricks for greater proteolytic activity"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Zhuoxin Yu (University of Medicine and Dentistry of New Jersey)
"MMP cleavage in a bacterial collagen system: mechanism and specificity"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetalloproteinases in the Omic Era
Discussion Leader: Chris Overall (University of British Columbia)
7:30 pm - 7:50 pmAlex Strongin (Sanford Burnham Medical Research Institute)
"Omics sheds light on nerve injury, neuropathic pain, and MMPs"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAlicia Arroyo (Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain)
"A degradome' walk to MT-MMPs in pathophysiology"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChris Overall (University of British Columbia)
"Unexpected Crucial roles for MMP12 in regulating PMNs, coagulation, and complement activation in arthritis revealed by degradomics"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmTayebeh Pourmotabbed (University of Tennessee Health Science Center)
"MMP-9: old enzyme, new function"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetalloproteinases in Cancer Progression I
Discussion Leader: James Quigley (Scripps Research Institute)
9:00 am - 9:20 amSharon Stack (University of Notre Dame)
"Matrix regulation of Wnt/β-catenin signaling and protease expression in ovarian cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKayla Bayless (Texas A&M University)
"Fine-tuning angiogenic sprout initiation"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amElena Deryugina (Scripps Research Institute)
"Neutrophil MMP-9 as a functional regulator of tumor angiogenesis and metastasis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amZena Werb (University of California-San Francisco)
"New functions for MMP-9 in tumor progression and response to therapy"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 am Hyeong-Reh Kim (Wayne State University)
"TIMP-1 activation of the tetraspanin / CD63 signaling complex during cancer progression"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Juan Carlos Rodríguez-Manzaneque (GENYO, Granada, Spain)
"Roles of ADAMTS1 during physiological- and tumor-associated vascularization"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetalloproteinases in Cancer Progression II
Discussion Leader: Howard Crawford (Stony Brook University)
7:30 pm - 7:50 pmH. Munshi (Northwestern University)
"Fibrosis-protease cross-talk regulates pancreatic cancer progression"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmYoshifumi Itoh (Imperial College London, UK)
"Invadopodia or not invadopodia? MT1-MMP localization to the substrate attachment site regulate cellular invasion"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDerek Radisky (Mayo Clinic)
"Rac1b, a constitutively activated splice isoform of Rac1 induced by matrix metalloproteinases, is a key effector of lung cancer progression"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmJian Cao (Stony Brook University)
"Inhibition of MT1-MMP-mediated cancer cell migration"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetalloproteinases in Development
Discussion Leader: Suneel Apte (Cleveland Clinic)
9:00 am - 9: 20 amZhongjun Zhou (University of Hong Kong)
"MT1-MMP regulates Notch signaling to maintain B lymphocyte development"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDarryl Russell (University of Adelaide, Australia)
"ADAMTS proteases and substrates in ovarian development and production of developmentally competent oocytes"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:45 amMarian Caikovski (Swiss Institute for Experimental Cancer Research)
"The role of ADAMTS18 in the mouse"
10:45 am - 10:50 amDiscussion
10:50 am - 11:05 amShuo Wei (University of West Virginia)
"ADAM13 induces vertebrate head structures by regulating a novel crosstalk between ephrinB and Wnt signaling"
11:05 am - 11:10 amDiscussion
11:10 am - 11:25 amJohanne Dubail (University of Liège)
"ADAMTS-2, -3 and -14 function in knock-out mice and zebrafish"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amAtsuko Sehara-Fujisawa (Kyoto University, Japan)
"Roles of ADAM19 in nervous system development in zebrafish"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmGhislain Opdenakker (University of Leuven, Belgium)
"The REGA model and MMP-9 in the development of the autoimmune antigen repertoire"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmMetalloproteinases in Disease
Discussion Leader: Judith Bond (Pennsylvania State University)
7:30 pm - 7:50 pmWilliam Parks (University of Washington)
"Moderation of Inflammation by MMP-10"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAnnie Pardo (Universidad Nacional Autonoma de Mexico)
"Involvement of MMP-19 in cell behavior and architectural remodeling in lung fibrosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJudith Bond (Pennsylvania State University)
"Meprins' role in acute and chronic inflammation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJosune Orbe (University of Navarra, Spain)
"MMP-10 effectively reduces brain damage in experimental stroke by enhancing fibrinolysis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Advances in Inhibition and Detection of Metalloproteinase
Discussion Leader: Keith Brew (Florida Atlantic University)
9:00 am - 9: 20 amDan Dransfield (Dyax Corp)
"Selective antibody MMP inhibitors"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amShahriar Mobashery (University of Notre Dame)
"Stopping and smelling the roses: tools in elucidation of the details of MMP-Dependent diseases"
10:00 amCoffee Break
10:30 am - 10:50 amRoy Black (Amgen)
"Return of the TIMPs: Therapeutic indications and strategies for TIMP-3"
10:50 - 11:00 amDiscussion
11:00 am - 11:15 amMatthew Bogyo (Stanford University)
"Methods for the selective inhibition and visualization of MMP activity"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amPeter Berget (Carnegie Mellon University)
"Fluorescent protease biosensors engineered from fluorogen activating proteins"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amElamprakash Savariar (University of California San Diego)
"In vivo imaging of MMP activities using FRET probes"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmStephen Prior (University of Portsmouth, UK)
"Rapid Structure Determination of MMP-Inhibitor Complexes using Swarm Intelligence"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetalloproteinase Translational Research: From the Bench to the Bedside
Discussion Leader: Stanley Zucker (Veterans Affairs Medical Center, Northport, NY)
7:30 pm - 7:50 pmElizabeth Heath (Karmanos Cancer Institute)
"Challenges in clinical development of MMP inhibitors"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:30 pmAchim Kruger (Technical University of Munich, Germany)
"The trouble with metalloproteinase inhibition in the clinic: lessons from TIMP-1-function"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmKaty Giorgiadis (Pfizer)
"AGG-523: Aggrecanase-selective Inhibitor for the treatment of osteoarthritis"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmStanley Zucker (Veterans Affairs Medical Center)
"Targeting metalloproteinases in the clinic: Time to break the mold"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

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