| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Novel Functions and Localizations of MMPs |
| Discussion Leader: Shuo Wei (West Virginia University, USA) |
| 3:45 pm - 3:50 pm | Introduction by Discussion Leader |
| 3:50 pm - 4:05 pm | Mariel Maldonado (Universidad Nacional Autónoma de México, Mexico)
"MMP-28 in Idiopathic Pulmonary Fibrosis (IPF)" |
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Anselm Sommer (University Hospital Schleswig-Holstein, Germany)
"Phosphatidylserine Exposure Represents the Final
Trigger for ADAM17-Mediated Proteolysis" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MMP Regulation, Detection and Control |
| Discussion Leader: Antoine Dufour (University of British Columbia, Canada) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:45 pm | Dina Hingorani (University of California, San Diego, USA)
"Developing MMP2, 9 and 14 Selective Ratiometric Activatable Cell
Penetrating Peptides (RACPPs) for Highlighting Tumor Positive Margins in Image
Guided Surgery" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Estefania Ugarte-Berzal (Rega Institute for Medical Research, KU Leuven, Belgium)
"The Hemopexin Domain of MMP-9 Inhibits Large Protein but Not Small Peptide Degradation: Involvement of Blades 4 and 1" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Mauro Prato (University of Torino, Italy)
"Dextran-Shelled Oxygen-Loaded Nanodroplets
Reestablish a Physiological Pro-Angiogenic Phenotype in Hypoxic Dermal
Endothelium: New Insights for Chronic Wound Healing" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Trung Nguyen (University of Notre Dame, USA)
"MMP8 Accelerates Healing
in Both Diabetic and Non-Diabetic Wounds" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Bettina Hieronimus (University of Hohenheim, Germany)
"MT4-MMP Is Highly Expressed in Human Melanoma
Cells: Characterization of Different Forms and Identification of Its
N-Glycosylation Site" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Christoffer Goth (Copenhagen Centre for Glycomics, Denmark)
"Modulation of Ectodomain Shedding by
Site-Specific O-Glycosylation: A Systematic Study of ADAM Mediated Shedding" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | MMPs (and Other Metalloproteinases) in Development and Disease |
| Discussion Leader: Dina Hingorani (University of California, San Diego, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:15 am | Shuo Wei (West Virginia University, USA)
"Xenopus ADAM19 Specifies Neural Crest Lineage Through Non-Proteolytic Stabilization of ADAM13" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Johanne Dubail (Cleveland Clinic Lerner Research Institute, USA)
"ADAMTS9 Regulates Ocular ECM During Development and Is Implicated in Anterior Segment Dysgenesis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Jeremy Frieling (Moffitt Cancer Center, USA)
"MMPs Generate Novel Osteogenic Peptides from
Parathyroid Hormone-Related Protein" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Antoine Dufour (University of British Columbia, Canada)
"Moonlighting MMP12
Decreases Breast Cancer Cell Prognosis by Cleavage of Intracellular Syk" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Pirjo Åström (University of Oulu, Finland)
"MMP8 Shows Antitumor
Properties in Oral Tongue Squamous Cell Carcinoma" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Keiichi Asano (Okayama University Graduate School, Japan)
"Impact of Versicanolysis in Tumor
Angiogenesis" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Keynote Session: Regulation and
Consequences of MMP-Dependent Pericellular Proteolysis |
| Discussion Leader: Anna Juncker-Jensen (NantBioScience, USA) |
| 1:30 pm - 1:35 pm | Opening Remarks |
| 1:35 pm - 2:20 pm | Stephen Weiss (University of Michigan, USA)
"Regulation and
Consequences of MMP-Dependent Pericellular Proteolysis" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
