Sunday 12/8
Session 1 | G-proteins in the nervous system |
Chair: Linda Buck (Harvard)
- Linda Buck (Harvard)
Deconstructing Smell
- Diomedes Logothetis (Mount Sinai School of Medicine, NY)
Regulation of activity of G protein-gated Potassium Channels
- Barry Dickson (IMP, Vienna)
Rho GTPase signalling pathways in axon guidance
Monday 13/8
Session 2 | G-proteins in the immune system |
Chair: Alan Hall (UCL, London)
- Alan Hall (UCL, London)
Regulation of cell migration by Rho GTPases
- Victor Tybulewicz (NIMR, London)
Rac GTPases and the exchange factor play critical roles in lymphocyte development and activation
- Doreen Cantrell (ICRF, London)
T cell functions for the GTPases Rac, Rho and Rap
- Jorge Galan (Yale)
Mimicry as a strategy to modulate cellular functions by bacterial pathogens
Monday 13/8
Session 3 | Structure & function of G-proteins |
Chair: Fred Wittinghofer (Max-Planck-Institut, Dortmund)
- Fred Wittinghofer (Max-Planck-Institut, Dortmund)
The GTPase module: an canonical switch with interesting variations
- Stephen Smerdon (National Institute for Medical Research, Mill Hill)
The Structural basis of Arfaptin-mediated cross-talk between Arf and Rac signalling pathways
- Mike Rosen (Sloan-Kettering Cancer Center, NY)
Structural and Dynamic Regulation of the Wiskott-Aldrich Syndrome Protein: Implications in Biophysics and Biology
Tuesday 14/8
Session 4 | G-proteins and Cancer Biology |
Chair: Dafna Bar-sagi (State University of New York)
- Dafna Bar-sagi (State University of New York)
Ras signaling and growth control
- George Prendergast (Wistar Institute, Philadelphia)
Rho and cancer: a selective role for RhoB in apoptotic responses of transformed cells
- John Collard (Netherlands Cancer Institute)
Rho-like GTPases in invasion and metastasis
- Shuh Narumiya (Kyoto University)
Rho and Rho effectors in cell migration
- Channing Der (University of North Carolina)
Ras and Rac signaling and transformation
Tuesday 14/8
Session 5 | New technologies in G protein research |
Chair: Julian Downward (ICRF, London)
- Julian Downward (ICRF, London)
Exploring Ras signalling pathways: profiling transcriptional and post-translational responses
- Mike Moran (MDS Proteomics)
Applications of Mass Spec to delineate small G protein signalling pathways and protein modifications
- Ravi Iyengar (Mount Sinai School of Medicine, NY)
The flexible design of the MAP-kinase network
Wednesday 15/8
Session 6 | G proteins in animal development |
Chair: Rick Firtel (UCSD)
- Rick Firtel (UCSD)
Sensing directionality through G protein-coupled pathways
- Linda Van Aelst (Coldspring Harbour)
AF-6/Canoe functions as a Rap1 effector in epithelial morphogenesis
Wednesday 15/8
Session 7 | Biological endpoints & GTPases |
Chair: Yoshimi Takai (Osaka University)
- Yoshimi Takai (Osaka University)
Rab3-interacting molecules in neurotransmitter release
- Richard Treisman (ICRF, London)
SRF: Linking the cytoskeleton to transcriptional regulation
- Silvio Gutkind (NIH)
Thursday 16/8
Session 8 | G proteins in Cell Movement |
Chair: Keith Burridge (University of North Carolina)
- Keith Burridge (University of North Carolina)
Adhesion-mediated regulation of Rho family proteins
- Martin Schwartz (Scripps Research Institute)
Regulation of Rac membrane targeting and effector interactions by integrins
- Vania Braga (Imperial College London)
Cell-cell adhesion versus migration
Thursday 16/8
Session 9 | G proteins - lessons from mammalian knockouts |
Chair: Mel Simon (California Institute of Technology)
- Mel Simon (California Institute of Technology)
Multiple mutants define specific G-protein pathway functions
- Matthias Wymann (Fribourg, Switzerland)
The G protein-coupled phosphoinositide 3-kinase - a key regulator of inflammation and allergy
- Jonathan Chernoff (Fox Chase Cancer Center, Philadelphia)
Genetic Analysis of PAK Function in Mammals
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