Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Evaluating the Complex Dynamics of Hippocampal Microcircuits"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Cryptic Changes to Degenerate Neurons and Circuits Elicited by Repeated Perturbations of Temperature and High Potassium"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Oscillations, Rhythms and Network Dynamics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
"Closed-Loop Control of Inhibitory Theta Phase Locking and Its Impact on Seizures and Cognition"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
"Spatially Modulated Hippocampal Rhythmic Discharges Impair Working Memory in a Rodent Model of TLE"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Long-Range GABAergic Projections from Prefrontal Cortex Regulate Hippocampal Disinhibition and Synchrony"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Multi-Regional Oscillation and Spiking Synchronization Coordinates Absence Seizure Generation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Rhythms of the Epileptic Brain"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Modulating Pathological Hippocampal-Cortical Dynamics in Temporal Lobe Epilepsy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Local and Long-Range Circuitry
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
"Mesoscale Ca2+ Imaging of Purkinje Cells Reveals Cerebellar Engagement During Chronic, Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
"All-Optical Interrogation of Hippocampal Circuits Using Voltage Imaging"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Large-Scale 3D Reconstruction of Inhibitory Circuits in an Injured Brain"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Unstable Hippocampal Population Codes Underlying Cognitive Deficits in Temporal Lobe Epilepsy"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Synaptic and Network Homeostasis
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
"Single Cell RNAseq Analysis of Metabolic Disruption Following Traumatic Brain Injury Suggests a Shift From Identity-Driven to Activity-Driven Metabolic Profiles"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
"How Genetic Disorders Reprogram the Lifespan Synaptome Architecture"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Neurotransmitter Phenotype Switching by Excitatory Spinal Interneurons Regulates Locomotor Recovery after Spinal Cord Injury"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Microcircuit Alterations Underlie the Emergence of Pathological High Frequency Oscillations"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"The Dynamics of Chloride Ion Driving Force in the Nervous System"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Identification of Candidate Neuronal Networks Coordinating Epileptic Activity Using Single Cell Omics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glial Signaling and Epileptogenesis
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
"Microglial P2Y6 Receptor Calcium Signaling Regulates Microglial Function in Epileptogenesis"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
"Peripheral Immune Cells as a Target in Epilepsy"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Maladaptive Myelination Promotes Progression of Generalized Epilepsy"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Myelination, a Critical Player in Inhibitory Neural Circuit Function"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Gene Targets and Therapies
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
"Lemur Tyrosine Kinase 3 (LMTK3) Modulates KCC2 Transporter Activity in the Dentate Gyrus via PP1-Dependent Pathway"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
"JAK/STAT Regulation of the Transcriptomic Response During Epileptogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Dissecting the Role of mTOR Complexes in Epilepsy"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Cav2.3 Phosphorylation in the Pathophysiology of CDKL5 Deficiency Disorder: a New Target for Treatment"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Identifying Gene Networks to Guide Drug Discovery in Structural Epilepsies"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"MicroRNA Targeting for Acquired and Genetic Epilepsies – Hits, Misses and Complexes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-canonical defects in Inhibitory signaling
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
"Mechanisms Regulating Sodium Channel ß1 Subunit Signaling and Transcriptional Modulation in Developmental and Epileptic Encephalopathies"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
"Interneuron Migration Deficits in Epileptic Encephalopathies"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Insights Into the Role of Astrocytic EAAT1 in Regulating Glutamate/Chloride Homeostasis and the Development of Neurological Disorders"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Perineuronal Nets: Unexpected Contributors to Epilepsy?"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
"Long-read Sequencing and Profiling of RNA-Binding Proteins Reveals the Pathogenic Mechanism of Aberrant Splicing of an SCN1A Poison Exon in Individuals with Epilepsy"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
"Molecular Insights into Human Brain Development and the Origin of Cortical Interneurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Mosaic Mutations, Malformations, mTOR, and More: the Role of Post-Zygotic Mutation in Developmental Epilepsies"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Somatic Mutations Activating MAPK Signaling in Mesial Temporal Lobe Epilepsy"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Brain Mosaicism in mTOR-related Cortical Malformation: Toward Novel Therapeutics Targets"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Temporal Manipulation of Scn1a Gene Expression in Dravet Syndrome"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Epigenetic and Metabolic Targets in Epileptic Brain
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
"Effects of Slc35a2 Knockout on Golgi Structure and Cortical Lamination"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
"Role of DNA Hydroxymethylation in the Cellular and Molecular Response to Epilepsy"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Role of sFRP3 in Seizure-Induced Dysregulation of Neurogenesis"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Epigenetic Disease Classification in Focal Epilepsies"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure