Multiscale Dynamics in the Emergence of Epilepsies

Epilepsies are multifactorial spectrum of disorders which evolves over time. This GRC seeks to advance our understanding the diverse underlying processes that transform a seemingly normal brain to “dynamically” develop sudden unprovoked and recurrent episodes of abnormal hypersynchronous activity. Presentations will highlight current advances in studying the multiscale processes involved in epileptogenesis, from alterations in genetic and molecular profiles to changes in cellular, neurovascular, neuroimmune, microcircuit and network function which contribute to development of epilepsy and comorbid disorders that impact patient quality of life. Discussions will explore dynamic interactions between multiple complex systems including network physiology, cell and immune signaling, metabolic processes and transcriptomic changes at different stages of the disease, and how they can be targeted as biomarkers or therapeutically. This GRC will bring together scientists of diverse backgrounds at all career stages from within and outside the field for interactive and stimulating discussions to advance epilepsy research and ultimately impact patient care.