Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Mechanisms Driving Transformations in Epilepsies
Discussion Leader: Martha Streng (University of Minnesota, United States)
3:45 pm - 3:55 pm
Introduction by Discussion Leader
3:55 pm - 4:25 pm
Jeanne Paz (Gladstone Institutes / University of California San Francisco, United States)
"From Injury to Epilepsy: Is the Focus out of Focus?"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Brain State Regulation of Excitability
Discussion Leader: Igor Timofeev (Cervo Brain Research Centre, Canada)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:00 pm
Mahad Ahmed (Stanford University, United States)
"Investigating the Role of Dentate Spikes in Temporal Lobe Epilepsy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Jiyun Shin (New York University School of Medicine, United States)
"In Search of Human Hippocampal Sharp-Wave Ripples During NREM Sleep"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Joseane Righes Marafiga (University of California San Francisco, United States)
"Cellular and Functional Abnormalities Underlying Spike-and-Wave Discharges in a C1qa Knockout Model of Epilepsy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Nariman Kiani (Aix-Marseille University, France)
"Spatiotemporal Regulation of Astrocytic K+ Clearance in Healthy and Epileptic State of the Brain"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Shayne Hastings (University of Minnesota, United States)
"Chronic On-Demand Cerebellar Stimulation Provides Continued Seizure Control in a Mouse Model of Temporal Lobe Epilepsy"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cells Types, Circuits and Therapeutic Strategies
Discussion Leader: Premysl Jiruska (Second Faculty of Medicine, Charles University, Czech Republic)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:30 am
Amr Ellaithy (Brigham and Women’s Hospital, United States)
"Mapping Epileptogenesis at Single Cell Resolution"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Zhangpeng Chen (Shanghai Jiao Tong University School of Medicine, China)
"Microglia-Mediated Inhibitory Synapses Pruning Drives Neuronal Hyperexcitability in Epilepsy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Olivia Hoffman (University of Wisconsin-Madison, United States)
"Transient Exposure to Tofacitinib in Chronic Epilepsy Leads to Enduring Seizure Suppression, Cognitive Repair and Profound Disease Modification"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Deepak Subramanian (University of California Riverside, United States)
"Toll-Like Receptor 4 Regulation of Matrix Metalloproteinase-9 Activity Promotes Early Pathogenesis after Traumatic Brain Injury"
10:30 am - 10:40 am
Discussion
10:40 am - 10:50 am
Haley Dame (Tufts University, United States)
"Development of Splice-Switching Antisense Oligonucleotides to Treat SCN8A Epilepsy"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Promoting Human and Career Path Diversity in Epilepsy
Discussion Leader: Karen Wilcox (University of Utah, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Human and Career Path Diversity in Epilepsy
Mattia Maroso (American Association for the Advancement of Science, United States)
Chanel Matney (The National Academies of Sciences, Engineering, and Medicine, United States)
Elaine O'Loughlin (CURE Epilepsy, United States)
Matt Kelley (AstraZeneca, United States)
Katja Kobow (Universitätsklinikum Erlangen, Germany)
Helen Scharfman (Nathan Kline Institute / New York University Langone Health, United States)
Viji Santhakumar (University of California, Riverside, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes